Results 181 to 190 of about 767,013 (353)

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Seroprevalence of hepatitis B and C viruses among waste handlers in Ethiopia: A systematic review and meta-analysis

SAGE Open Medicine
Objective: Hepatitis B virus and hepatitis C virus are the leading causes of global liver-related morbidity and mortality. Waste handlers are one of the high-risk groups for hepatitis B virus and hepatitis C virus acquisition. Thus, the aim of this study
Alemu Gedefie, Fekadeselassie Belege Getaneh, Habtu Debash, Saleamlak Sebsibe, Yonas Erkihun, Ermiyas Alemayehu, Yeshi Metaferia, Yeshimebet Kassa, Agumas Shibabaw, Mihret Tilahun, Getachew Mesfin Bambo, Samuel Sahile Kebede, Mekuanent Alemu, Wondmagegn Demsiss   +13 more
doaj   +1 more source

Editorial Commentary: Does HIV Remain a Risk Factor for Achieving Sustained Virologic Response Under Direct Acting Antiviral-Based Modern Hepatitis C Virus Therapy? [PDF]

, 2014
Jürgen K. Rockstroh
openalex   +1 more source

Involvement of Host ATR-CHK1 Pathway in Hepatitis B Virus Covalently Closed Circular DNA Formation [PDF]

, 2020
Jun Luo, Laurie Luckenbaugh, Hui Hu, Zhipeng Yan, Lu Gao, Jianming Hu   +5 more
openalex   +1 more source

Dried blood spot analysis in antidoping: Technical challenges, analytical advances, and future perspectives

Bulletin of the Korean Chemical Society, EarlyView.
Dried blood spot (DBS) analysis enables minimally invasive blood collection with strong analyte stability and simplified logistics, supporting anti‐doping applications beyond traditional matrices. Recent advances address hematocrit, volume variability, and matrix effects while expanding coverage to steroid esters, World Anti‐Doping Agency‐listed ...
Jihyun Yoon, Jiyeong Hong, Hanbin Oh, Chi Hwan Lee, Ki Hun Kim   +4 more
wiley   +1 more source

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

Host Ethnicity and Virus Genotype Shape the Hepatitis B Virus-Specific T-Cell Repertoire

, 2008
Anthony T. Tan, Elisabetta Loggi, Carolina Boni, Adeline Chia, Adam J. Gehring, Konduru S. Sastry, Vera J. Goh, Paola Fisicaro, Pietro Andreoné, Christian Brander, Seng Gee Lim, Carlo Ferrari, Florian Bihl, Antonio Bertoletti   +13 more
openalex   +2 more sources

Expression of mutant TIE2 p.L914F during mouse development causes embryonic lethality and defects in vascular remodeling

Developmental Dynamics, EarlyView.
Abstract Background Sporadic venous malformation (VM) is associated with the hyperactivating p.L914F mutation in TIE2, a receptor tyrosine kinase essential for vascular development. This mutation is not found in hereditary VM, suggesting incompatibility with life when expressed during early vascular development.
Lindsay J. Bischoff, Sandra Schrenk, Kara Soroko, Chhiring Sherpa, Ashok Arasu, Damien Reynaud, Elisa Boscolo   +6 more
wiley   +1 more source

Polyunsaturated liposomes are antiviral against hepatitis B and C viruses and HIV by decreasing cholesterol levels in infected cells

, 2010
Stephanie Pollock, Norica Nichita, Annette Isabel Böhmer, Cristina Radulescu, Raymond A. Dwek, Nicole Zitzmann   +5 more
openalex   +2 more sources

A natural mutation of the hepatitis B virus X gene affects cell cycle progression and apoptosis in Huh7 cells [PDF]

, 2012
Chang Hee Yang, Byung‐Cheol Song, Moonjae Cho   +2 more
openalex   +1 more source