Results 111 to 120 of about 999,068 (357)

Lactylated SPTAN1 Accelerates Hepatocellular Carcinoma Progression by Promoting NOTCH1/HES1 Activation and Immunosuppression

Advanced Science, EarlyView.
This study identifies SPTAN1‐kla as a novel oncogenic driver in HBV‐driven HCC, linking metabolic, epigenetic, and immune mechanisms. SPTAN1‐kla promotes HCC progression via NOTCH1/HES1 activation and immunosuppression. Findings highlight that targeting SPTAN1‐kla provides a framework for HCC treatment to improve clinical outcomes in HBV infected ...
Zengbin Wang, Dongjie Ye, Linqing Wu, Jiayu Liu, Banglun Pan, Zhu Zhang, Xiaoxia Zhang, Yuxin Yao, Nanhong Tang   +8 more
wiley   +1 more source

Prevención de la transmisión materno-infantil del VIH en gestantes y madres awajún y wampis de la región Amazonas en Perú

Revista Peruana de Medicina Experimental y Salud Pública, 2017
Objetivos. Identificar las barreras que limitan el cumplimiento de las medidas de prevención de la transmisión maternoinfantil (TMI) del VIH, en comunidades indígenas de la región Amazonas en Perú. Materiales y métodos.
Byelca Huamán, Alfonso Gushiken, Carlos Benites, Fabiola Quiroz, Lisset García-Fernández   +4 more
doaj   +1 more source

Knowledge of Hepatitis B Vaccine among Operating Room Personnel in Nigeria and Their Vaccination Status [PDF]

, 2011
Emeka B Kesieme, Kenechi Uwakwe, Eshiobo Irekpita, Andrew E. Dongo, Kefas John Bwala, Bamidele Johnson Alegbeleye   +5 more
openalex   +1 more source

Procyanidin Capsules Combat ALF by Restoring Mitochondrial Homeostasis and Inhibiting Necroptosis via the PGAM5/DRP1/PINK1 Pathway

Advanced Science, EarlyView.
A biomimetic self‐assembly strategy, Procyanidin Capsules (PC‐Ca), has been developed, which has great stability, bioavailability, and liver‐targeting efficacy and modulates the KEAP1‐NRF2 axis to inhibit ROS formation and necroptosis, regulate mitochondrial homeostasis through the PGAM5/DRP1/PINK1 signaling pathway in thioacetamide (TAA)‐induced ALF ...
Qing Shi, Minmin Wu, Jinwei Zhong, Chao Chen, Zhuang Huang, Jingxuan Peng, Dong Yang, Xingjie Zan, Zhengfei Wang   +8 more
wiley   +1 more source

B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns

Advanced Science, EarlyView.
B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang, Youtao Wang, Cong Sun, Tao Liu, Zengfeng Wu, Lipeng Chen, Lina Chen, Penglin Li, Zhengkang Li, Cangui Zhang, Bingyun Lu, Ye Chen, Bing Gu, Qian Zhong, Xin Wei Wang, Mu‐Sheng Zeng, Jinping Liu   +16 more
wiley   +1 more source

Mutation Hot Spots in Hepatitis B Surface Antigen in Chronic Carriers from Khoozestan Province, Southern of Iran

Iranian Journal of Allergy, Asthma and Immunology, 2013
Mutations in the human hepatitis B virus (HBV) genome contribute to its escape from host immune surveillance and result in persistent infections. The aim of this study was to characterize the molecular variations of the surface gene and protein in ...
Fatemeh Ramezani, Mehdi Norouzi, Gholam Reza Sarizade, Vahdat Poortahmasebi, Ebrahim Kalantar, Lars Magnius, Helen Norder, Esteban Domingo, Seyed Mohammad Jazayeri   +8 more
doaj  

Plasma interleukin-7 correlation with human immunodeficiency virus RNA and CD4+ T cell counts, and interleukin-5 with circulating hepatitis B virus DNA may have implications in viral control [PDF]

, 2022
Jaisheela Vimali, Yean K. Yong, Amudhan Murugesan, Kumaran Vishnupriya, Ashwin Rajeev, Evangeline Ann Daniel, Pachamuthu Balakrishnan, Sivadoss Raju, Rosmawati Mohamed, Vijayakumar Velu, Marie Larsson, Esaki M. Shankar   +11 more
openalex   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source

Changing trends of Hepatitis B seromarkers amongst pakistani population: a laboratory-based review [PDF]

, 2013
Objective: To study the changing trends of hepatitis B markers tested at Aga Khan University Hospital clinical laboratory according to the internationally recognised classification of hepatitis B profile.
Jafri, Wasim, Khan, Erum, Khan, Muhammad Shoaib, Moiz, Bushra, Zafar, Afia   +4 more
core   +1 more source

HoxA10 Facilitates SHP-1-Catalyzed Dephosphorylation of p38 MAPK/STAT3 To Repress Hepatitis B Virus Replication by a Feedback Regulatory Mechanism [PDF]

, 2019
Qingyu Yang, Zhang Qi, Xuewu Zhang, Lei You, Wenbiao Wang, Weiyong Liu, Yang Han, Chunqiang Ma, Wei Xu, Junbo Chen, Hua Yang, Pin Wan, Yao Zhou, Yingle Liu, Kailang Wu, Ziwen Yang, Jianguo Wu   +16 more
openalex   +1 more source