Results 111 to 120 of about 575,334 (316)

AI‐Assisted Drug Re‐Purposing for Human Liver Fibrosis

Advanced Science, EarlyView.
A multi‐agent AI (AI co‐scientist) is used to repurpose drugs for liver fibrosis treatment and to guide their experimental characterization. The anti‐fibrotic efficacy and toxicity of these drugs is assessed in multi‐lineage human hepatic organoids grown in microwells (microHOs).
Yuan Guan, Lu Cui, Jakkapong Inchai, Zhuoqing Fang, Jacky Law, Alberto Alonzo Garcia Brito, Annalisa Pawlosky, Juraj Gottweis, Alexander Daryin, Artiom Myaskovsky, Lakshmi Ramakrishnan, Anil Palepu, Kavita Kulkarni, Wei‐Hung Weng, Zhuanfen Cheng, Vivek Natarajan, Alan Karthikesalingam, Keran Rong, Yunhan Xu, Tao Tu, Gary Peltz   +20 more
wiley   +1 more source

Epidemiology of acute hepatitis B in a university hospital in São Paulo, Brazil: retrospective study of two five-year periods

São Paulo Medical Journal
CONTEXT: HBV infection is endemic in Brazil and acute HBV infection is still a common disease. OBJECTIVE: To analyze incidence, risk factors and evolution of acute HBV infection. SETTING: University Hospital.
Maria Lúcia Gomes Ferraz, Alessandra Yoradjian, Andrea Barbieri, Virginia Figueiredo, Edmundo Lopes Neto, Cibele Nascimento Cruz, Antonio Eduardo Silva   +6 more
doaj   +1 more source

B‐EPIC: A Transformer‐Based Language Model for Decoding B Cell Immunodominance Patterns

Advanced Science, EarlyView.
B‐Epic: Achieving high‐accuracy B cell epitope prediction through Transformer architecture. Comprehensive validation demonstrates B‐Epic's robust performance across diverse datasets. B‐Epic facilitates vaccine development for H. pylori and EBV, addressing critical public health challenges.
Jun‐Ze Liang, Youtao Wang, Cong Sun, Tao Liu, Zengfeng Wu, Lipeng Chen, Lina Chen, Penglin Li, Zhengkang Li, Cangui Zhang, Bingyun Lu, Ye Chen, Bing Gu, Qian Zhong, Xin Wei Wang, Mu‐Sheng Zeng, Jinping Liu   +16 more
wiley   +1 more source

Biophysical and Biochemical Heterogeneity of Purified Hepatitis B Antigen [PDF]

, 1972
Gordon R. Dreesman, F. Blaine Hollinger, Juan Suriano, Roger S. Fujioka, J. P. Brunschwig, J L Melnick   +5 more
openalex   +1 more source

Secondary Bile Acids Modified by Odoribacter Splanchnicus Alleviate Colitis by Suppressing Neutrophil Extracellular Trap Formation

Advanced Science, EarlyView.
In ulcerative colitis, the loss of Odoribacter splanchnicus disrupts a microbiota‐metabolite‐neutrophil axis. Restoring this bacterium boosts lithocholic acid, which suppress neutrophil extracellular trap formation and eases colonic inflammation.
Jing Xu, Jianhong Li, Xue Guo, Chen Huang, Yao Peng, Haoming Xu, Yingfei Li, Jingkui Xu, Jinxia Hu, Yitong Liao, Yuqiang Nie, Youlian Zhou   +11 more
wiley   +1 more source

Vertical transmission of hepatitis B surface antigen in carrier mothers in two west London hospitals. [PDF]

, 1979
D Woo, M. Cummins, Pamela Davies, Donald Harvey, R Hurley, A. P. Waterson   +5 more
openalex   +1 more source

Transfer Learning and Permutation‐Invariance Improving Predicting Genome‐Wide, Cell‐Specific and Directional Interventions Effects of Complex Systems

Advanced Science, EarlyView.
SETComp, a transfer learning model based on permutation‐invariance, is pre‐trained on single‐compound intervention data and fine‐tuned on complex system (e.g., natural products) data. The model achieves up to 93.86% accuracy on complex system‐cell‐gene association predictions, outperforming the baseline by up to 27.59%.
Boyang Wang, Boyu Pan, Tingyu Zhang, Qingyuan Liu, Shao Li   +4 more
wiley   +1 more source

Relationship between membrane-bound immunoglobulin and viral antigens in liver cells from patients with hepatitis B virus infection

, 1979
Andrea Trevisan, G. Realdi, A. Albertí, F. Noventa   +3 more
openalex   +1 more source

Inhaling Eugenol Inhibits NAFLD by Activating the Hepatic Ectopic Olfactory Receptor Olfr544 and Modulating the Gut Microbiota

Advanced Science, EarlyView.
Inhalable eugenol (EUG) from clove oil attenuates NAFLD by activating hepatic olfactory receptor Olfr544, triggering cAMP/PKA/CREB signaling to enhance lipolysis/oxidation. EUG concurrently restores gut microbiota, enriching probiotics (L. reuteri XR23/L. johnsonii XR25) and metabolites (IPA/5‐HIAA) that suppress lipogenesis.
Xiao‐Ran Wang, Zhan‐Zhan Li, Shu‐Ding Sun, Ya‐Gang Song, Jin‐Xin Miao, Xiang‐Xiang Wu, Yong‐Li Han, Xiao‐Lei Zhang, Wen‐Jing Chen, Qing‐Hua Wang, Yu Zhang, Yiping Fu, Yu‐ting Liu, Lin‐yan Lang, Wen‐Xia Zhao, Ming‐San Miao   +15 more
wiley   +1 more source

Estudio de fase I de la gammaglobulina hiperinmune anti-hepatitis B, con criterios de exclusión o sin estos Study of the phase I of antihepatitis B hyperimmune gammaglobulin with or without exclusion criteria

Revista Cubana de Investigaciones Biomédicas, 2004
Se evaluó la seguridad fase I de la gamma hiperinmune producida en Cuba contra la hepatitis B, en una muestra de personas con antecedentes alérgicos y sin estos.
Antonio González Griego, Ramón Caro Machado, Josué Acosta Acosta, Victoria González Ramírez, Elsa García Castillo, Jorge Arturo  Santiesteban, Alina Alerm, Victoria Ramírez   +7 more
doaj