Results 81 to 90 of about 13,757,225 (358)

Surface protein mutations in chronic hepatitis B patients who received hepatitis B vaccine therapy [PDF]

Iranian Journal of Basic Medical Sciences, 2014
Objective (s):The aim of this study was to determine the correlation between vaccine therapy and appearance of mutations in hepatitis B surface antigen (HBsAg)-positive chronic hepatitis B virus (HBV) patients. Materials and Methods: 16 patients received
Maryam Daram, Ghodratollah Montazeri, Hadi Karimzadeh, Reza Malekzadeh, Mahmood Mahmoodi, Zahra Goodarzi, Hossein Keyvani, Shahram Mirmomen, Seyed Moayed Alavian, Michael Roggendorf, Seyed Mohammad Jazayeri   +10 more
doaj  

Revealing Cell‐Free Mitochondrial DNA Breakage Patterns as Novel Biomarkers for Sepsis

Advanced Science, EarlyView.
Uncovering distinct plasma cfmtDNA breakage patterns opens new frontiers for early sepsis detection and prognosis. Unique cleavage hotspots in RNR2 and COX2 regions outperform traditional biomarkers, while mechanistic insights suggest bacterial endonuclease involvement.
Haitang Liao, Ruiyan Ma, Shuai Hao, Xuxin Tan, Xue Zeng, Rui Song, Bing Chen, Zhezhe Cao, Wei Shen, Zhenchun Luo, Jianfeng Huang, He Huang, Liangming Liu, Chenyang Duan   +13 more
wiley   +1 more source

NSP7 Molecular Degrader Attenuates Coronaviral Infection Through the β‐TrCP1/FBXO5 Axis

Advanced Science, EarlyView.
Host E3 ligase FBXO5 as a key regulator that promotes K48‐linked ubiquitination and proteasomal degradation of SARS‐CoV‐2 NSP7, thereby suppressing viral replication. NSP7 ubiquitination is co‐regulated by β‐TrCP1 and TAF1. Small molecule BC24877 disrupts β‐TrCP1‐mediated degradation of FBXO5, stabilizing FBXO5 and enhancing NSP7 clearance ...
Yao Tong, Travis B. Lear, Ferhan Tuncer, John J. Villandre, Áine N. Boudreau, Bo Lin, Irene Alfaras, Jason R. Kennerdell, Daniel P. Camarco, Mads B. Larsen, Yun Hua, Yanwen Chen, Meigin E. Chandler, Ricardo Pineda, Simon M. Barratt‐Boyes, John W. Evankovich, Toren Finkel, Yuan Liu, Bill B. Chen   +18 more
wiley   +1 more source

Combination of Tenofovir Disoproxil Fumarate and Peginterferon α-2a Increases Loss of Hepatitis B Surface Antigen in Patients With Chronic Hepatitis B.

Gastroenterology, 2016
BACKGROUND & AIMS Patients chronically infected with the hepatitis B virus rarely achieve loss of serum hepatitis B surface antigen (HBsAg) with the standard of care.
P. Marcellin, S. Ahn, Xiaoli Ma, F. Căruntu, W. Tak, M. Elkashab, W. Chuang, S. Lim, F. Tabak, R. Mehta, J. Petersen, G. Foster, L. Lou, E. Martins, Phillip Dinh, Lanjia Lin, A. Corsa, P. Charuworn, G. Subramanian, H. Reiser, H. Reesink, S. Fung, S. Strasser, H. Trinh, M. Buti, G. Gaeta, A. Hui, G. Papatheodoridis, R. Flisiak, H. Chan   +29 more
semanticscholar   +1 more source

Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation‐Dependent Tim‐3 Lysosomal Sorting and Degradation

Advanced Science, EarlyView.
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui, Xinhang Meng, Yujie Luo, Jinfeng Qian, Fengrun Sun, Mingke Qiu, Songcun Wang   +6 more
wiley   +1 more source

Melatonin Modulates Glucose Metabolism Reprogramming via Targeting G6PD to Alleviate Lead‐Induced Hepatocytes Pyroptosis in Common Carp (Cyprinus carpio L.)

Advanced Science, EarlyView.
This study reveals that Lead reprograms glucose metabolism to enhance H3K18la, driving DRP1‐dependent mitochondrial DNA leakage and cGAS‐STING‐mediated pyroptosis. Melatonin targets G6PD to suppress glycolysis‐driven H3K18la and restore mitochondrial homeostasis, thereby alleviating Lead‐induced liver injury in common carp through disruption of the ...
Zhiying Miao, Xiaofeng Ji, Lai Wei, Zhiruo Miao, Shiwen Xu   +4 more
wiley   +1 more source

Active immunization against hepatitis B virus (HBV) with low-doses of plasma-derived vaccine by intradermal route

Revista do Instituto de Medicina Tropical de São Paulo, 1989
Schedule for vaccination against HBV infection has usually been based on three separate injections of 20 meg of the vaccine by intramuscular route. One of the main shortcomings to its use in large scale programs has been its high cost.
Flair José Carrilho, Maria Lúcia Queiroz, Luiz Caetano da Silva, Luís Edmundo Pinto da Fonseca, Celso Granato, Isabel Oba, Leda Obara   +6 more
doaj   +1 more source

Engineered Probiotic‐Powered Micro‐Rod Robot Bomb for Thrombus‐Penetrating Explosion

Advanced Science, EarlyView.
For thrombotic diseases with narrow therapeutic windows and persistent vascular damage; existing thrombolytic drugs are difficult to achieve precise; timely; and sustained thrombolytic effects. Here an engineered probiotic driven micro‐rod robot for targeted and penetrative treatment for thrombus is developed.
Riyue Liu, Jiale Chen, Yuanyuan Li, Nawsherwan, Cuilian Dai, Yan Wang, Jinrong Zheng, Kecheng Zhou, Mangmang Sang   +8 more
wiley   +1 more source

Prevención de la transmisión materno-infantil del VIH en gestantes y madres awajún y wampis de la región Amazonas en Perú

Revista Peruana de Medicina Experimental y Salud Pública, 2017
Objetivos. Identificar las barreras que limitan el cumplimiento de las medidas de prevención de la transmisión maternoinfantil (TMI) del VIH, en comunidades indígenas de la región Amazonas en Perú. Materiales y métodos.
Byelca Huamán, Alfonso Gushiken, Carlos Benites, Fabiola Quiroz, Lisset García-Fernández   +4 more
doaj   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source