Results 11 to 20 of about 281,611 (124)
Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 81-90, January 2023., 2023 XELOXIRI neoadjuvant chemotherapy appears to be feasible and efficacious for patients with LARC. Although neoadjuvant XELOXIRI alone did not yield our expected pCR rate, the local recurrence rate, 3‐year DFS and measures of safety met current standards.
Chu Matsuda +16 more
wiley +1 more source
Annals of Gastroenterological Surgery, Volume 7, Issue 1, Page 138-146, January 2023., 2023 High tumor budding is a new candidate for an additional determinant of the T category in staging ICC. An LCSGJ staging system containing an additional evaluation of tumor budding may lead to improved staging accuracy. Abstract Purpose This retrospective study evaluated our hypothesis that high tumor budding (≥10 buds) may help determine the appropriate
Hisashi Kosaka +9 more
wiley +1 more source
Q fever outbreak in the terraced vineyards of Lavaux, Switzerland
New Microbes and New Infections, EarlyView., 2014 Abstract Coxiella burnetii infection (Q fever) is a widespread zoonosis with low endemicity in Switzerland, therefore no mandatory public report was required. A cluster of initially ten human cases of acute Q fever infections characterized by prolonged fever, asthenia and mild hepatitis occurred in 2012 in the terraced vineyard of Lavaux ...
C. Bellini +9 more
wiley +1 more source
Cancer Communications, Volume 42, Issue 12, Page 1257-1287, December 2022., 2022 Abstract Clustered regularly interspaced short palindromic repeats‐associated protein (CRISPR/Cas9), an adaptive microbial immune system, has been exploited as a robust, accurate, efficient and programmable method for genome targeting and editing. This innovative and revolutionary technique can play a significant role in animal modeling, in vivo genome
Khaled S. Allemailem +6 more
wiley +1 more source
Advances in exosome biomarkers for cervical cancer
Cancer Medicine, Volume 11, Issue 24, Page 4966-4978, December 2022., 2022 Cancer‐derived exosomes may promote CC metastasis by boosting cellular epithelial‐mesenchymal transformation (EMT), controlling the proliferation, invasion, or migration of cancer cells, as well as influencing immune escape and aiding angiogenesis.
Zihan Ran +5 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Cancer, Volume 129, Issue 3, Page 393-404, 1 February 2023., 2023 Abstract Background This study attempts to detect the expression of FoxP3, CD68, CD8α, and PD‐L1 in the tumor microenvironment (TME) of intrahepatic cholangiocarcinoma (ICC), and analyze the relationship between the corresponding cells and clinicopathological characteristics as well as prognosis of ICC.
Yiling Zheng +7 more
wiley +1 more source
Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Clinical Pharmacology in Drug Development, Volume 12, Issue 1, Page 77-84, January 2023., 2023 Abstract Intravenous edaravone is used to treat patients with amyotrophic lateral sclerosis. This randomized, open‐label, two‐way crossover, single‐dose phase 1 study compared the relative bioavailability of a newly developed edaravone oral suspension when administered orally and via a nasogastric tube (NGT) as a model of percutaneous endoscopic ...
Hidetoshi Shimizu +6 more
wiley +1 more source
Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors
Molecular Oncology, EarlyView.Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi +6 more
wiley +1 more source