Results 21 to 30 of about 281,611 (124)

Epithelial PD‐L1 expression at tumor front predicts overall survival in a cohort of oral squamous cell carcinomas from Sudan

Clinical and Experimental Dental Research, Volume 8, Issue 6, Page 1467-1477, December 2022., 2022
Abstract Background We recently described the tumor immune microenvironment (TIME) in oral squamous cell carcinomas (OSCC) from Sudan by assessing the core of the lesions. However, the invasive tumor front (ITF) is the most active part of OSCC lesions; thus, TIME should also be characterized at the ITF in this patient cohort.
Nuha M. Gaafar, Tarig Al‐Hadi Osman, Mariam Elsheikh, Israa Abdulrahman Ahmed, Harsh Dongre, Siren Fromreide, Ahmed M. Suleiman, Anne C. Johannessen, Elisabeth S. Nginamau, Daniela‐Elena Costea   +9 more
wiley   +1 more source

Reconstitution of CXCR3+ CCR6+ Th17.1‐Like T Cells in Response to Ofatumumab Therapy in Patients With Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background and Objectives Ofatumumab, a fully human anti‐CD20 monoclonal antibody, is effective in reducing relapses and disability progression in patients with multiple sclerosis. This study aimed to examine immune profile changes associated with ofatumumab in a prospective cohort of Chinese patients with relapsing–remitting multiple ...
Shu Yang, Tian‐Xiang Zhang, Jia Liu, Zhirui Liu, Lijie Zhu, Yan‐Yan Li, Bin Feng, Moli Fan, Fu‐Dong Shi, Chao Zhang   +9 more
wiley   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Evaluation of ABCA1 gene polymorphism as a prognostic index of fibrosis progression in NAFLD patients

Endocrinology, Diabetes &Metabolism, Volume 6, Issue 1, January 2023., 2023
Dyslipidemias, hepatic steatosis index, and ABCA1 (rs1800977) gene polymorphism CC genotype; were the only independent predictors of advanced fibrosis in NAFLD‐patients. Abstract Introduction It had been evident that non‐alcoholic fatty liver disease (NAFLD) is the new era epidemic.
Samar E. Ghanem, Maha M. Elsabaawy, Mervat M. Abdelkareem, Marwa L. Helal, Warda Othman, Mahitab Elsayed, Dalia M. Elsabaawy, Ashraf El Fert   +7 more
wiley   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Nonequilibrium antigen recognition during infections and vaccinations [PDF]

arXiv, 2023
The immune response to an acute primary infection is a coupled process of antigen proliferation, molecular recognition by naive B cells, and their subsequent proliferation and antibody shedding. This process contains a fundamental problem: the recognition of an exponentially time-dependent antigen signal.
arxiv  

Evaporation‐Enhanced Redox Cycling for Rapid Detection of Attomolar SARS‐CoV‐2 Virions Using Nanolithography‐Free Electrochemical Devices

Advanced Materials Technologies, EarlyView.
This study presents microfabricated electrochemical sensors for detecting ultralow viral particles counts through evaporation‐enhanced redox cycling (E2RC). To achieve sub‐micrometer gap in interdigitated microelectrodes, a scalable, nanolithography‐free fabrication method is developed.
Pouya Soltan Khamsi, Vinay Kammarchedu, Aida Ebrahimi   +2 more
wiley   +1 more source

Functional activity of peptide ion channels in tethered bilayer lipid membranes: Review

Electrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022
Abstract Ion transport across biomembranes plays a major role in living cells. This fundamental function is normally carried out by molecules with both a hydrophobic and a hydrophilic side (amphiphilic molecules), which aggregate within the membrane forming a hydrophilic pore (the ion channel) permitting the selective translocation of permeant ions ...
Rolando Guidelli, Lucia Becucci
wiley   +1 more source

Progress in Surface Plasmon and Other Resonance Biosensors for Biomedical Applications

Advanced Materials Technologies, EarlyView.
This is the shortened version: Recent advancements in surface plasmon resonance and other optical resonance biosensors for biomedical applications are presented. Advanced sensing strategies are examined for the detection of diverse analytes, integration of nanomaterials and machine learning, and emerging nonplasmonic modes like guided mode resonance ...
Faten Bashar Kamal Eddin, Houxin Fan, Zhenchao Liu, Paolo Donati, Youssef Amin, Yap Wing Fen, Junbo Liang, Pier Paolo Pompa, Sailing He   +8 more
wiley   +1 more source

Dual‐gate ion‐sensitive field‐effect transistors: A review

Electrochemical Science Advances, Volume 2, Issue 6, December 2022., 2022
Abstract Ion‐sensitive field‐effect transistors (ISFETs) are electrochemical sensors that work on the principle of metal‐oxide field‐effect transistors. Dual‐gate ion‐sensitive field‐effect transistors (DGISFETs) are an advanced version of ISFETs with an additional gate dielectric, resulting in sensitivity enhancement on account of the coupling of the
Deepa Bhatt, Siddhartha Panda
wiley   +1 more source