Results 111 to 120 of about 141,694 (266)

Suppression of Indoleamine 2,3‐Dioxygenase Enhances Immune Responses to the Therapeutic Vaccine for Chronic Hepatitis B

Hepatology Research, EarlyView.
Indoleamine 2,3‐dioxygenase (IDO) activity modulates immune responses to the therapeutic HBV vaccine NASVAC. Genetic or pharmacological suppression of IDO enhanced vaccine efficacy in mice, and lower serum kynurenine levels predicted favorable responses in humans, suggesting IDO as both a therapeutic target and a biomarker.
Yohei Shirakami, Soranobu Ninomiya, Takayasu Ideta, Ayumu Kanbe, Toshihide Maeda, Daisuke Minowa, Daisuke Taguchi, Masaya Kubota, Hiroyasu Sakai, Kenji Imai, Yasuko Yamamoto, Hiroyasu Ito, Kuniaki Saito, Osamu Yoshida, Yoichi Hiasa, Masahito Shimizu   +15 more
wiley   +1 more source

Updated Burden and Long‐Term Projections of Chronic Hepatitis B and C in Japan: A Nationwide Markov Modeling Study

Hepatology Research, EarlyView.
ABSTRACT Aim Chronic hepatitis B virus (HBV) and hepatitis C virus (HCV) infections remain major causes of liver‐related morbidity and mortality worldwide. Although Japan has implemented nationwide screening and treatment programs for decades, updated nationwide estimates and long‐term projections are limited.
Junko Tanaka, Akemi Kurisu, Ko Ko, Aya Sugiyama, Tomoyuki Akita   +4 more
wiley   +1 more source

Diagnostic Impact of Two‐Dimensional Shear Wave Elastography for Liver Fibrosis: A Multicenter Retrospective Study

Hepatology Research, EarlyView.
Two‐dimensional shear wave elastography demonstrated strong correlation with magnetic resonance elastography and high diagnostic accuracy for liver fibrosis across stages in 744 patients with chronic liver disease, supporting its role as a reliable non‐invasive tool for fibrosis assessment.
Takashi Nishimura, Toshifumi Tada, Yasuaki Suzuki, Kento Imajo, Katsutoshi Sugimoto, Sadanobu Ogawa, Hidenori Toyoda, Tamami Abe, Hidekatsu Kuroda, Masashi Hirooka, Asako Nogami, Satoshi Oeda, Hirokazu Takahashi, Tomoyuki Akita, Reiichiro Kondo, Takuma Nakatsuka, Ryosuke Tateishi, Yoichi Hiasa, Yuichiro Eguchi, Atsushi Nakajima, Hirohisa Yano, Shigehiro Kokubu, Junko Tanaka, Fuminori Moriyasu, Masayoshi Kage, Takashi Kumada, Hiroko Iijima   +26 more
wiley   +1 more source

Hepatitis B Surface Antigen Loss and Improved Clinical Outcomes in US Individuals With Chronic Hepatitis B Virus Infection. [PDF]

J Viral Hepat
Drysdale M, Chang R, Wang S, Coutinho A, Gielen V, Man T, Song R, Duh MS, Khalili M, Theodore D.   +9 more
europepmc   +1 more source

A Novel Diagnostic Approach for Hepatocellular Carcinoma Using Glycosylated Ferritin

Hepatology Research, EarlyView.
The percentage of glycosylated ferritin relative to total ferritin (%GF) is a novel biomarker for hepatocellular carcinoma (HCC), showing diagnostic performance comparable to that of AFP and DCP. We developed the GFAD index by integrating age, sex, %GF, AFP, and DCP, achieving improved diagnostic accuracy with high sensitivity and specificity. ABSTRACT
Akiyo Ishiguro, Yutaka Suehiro, Issei Saeki, Maho Egusa, Norikazu Tanabe, Toshihiko Matsumoto, Tsuyoshi Ishikawa, Yuki Kunimune, Toshihiko Kobayashi, Mitsuaki Nishioka, Taro Takami, Takahiro Yamasaki   +11 more
wiley   +1 more source

On-treatment viral factors affect subsequent hepatitis B surface antigen seroclearance in patients treated with nucleos(t)ide analogs for > 10 years. [PDF]

J Gastroenterol
Hosaka T, Hikita H, Tahata Y, Yamada R, Murai K, Miyazaki M, Ishida H, Hosui A, Sakamori R, Tatsumi N, Doi Y, Ohkawa K, Egawa S, Nawa T, Nozaki Y, Imanaka K, Nakahara M, Sakakibara M, Yakushijin T, Yoshida Y, Ogawa H, Usui T, Matsumoto K, Maesaka K, Shirai K, Makino Y, Saito Y, Kodama T, Takehara T.   +28 more
europepmc   +1 more source

Anti‐Integrin αvβ6 Autoantibodies as Diagnostic and Monitoring Biomarkers for Pediatric‐Onset Primary Sclerosing Cholangitis

Hepatology Research, EarlyView.
Levels of anti‐integrin αvβ6 antibodies were significantly higher in pediatric‐onset primary sclerosing cholangitis (PSC) than in autoimmune hepatitis (AIH) and may reflect disease activity. These antibodies may serve as a novel biomarker for distinguishing PSC from AIH and for monitoring disease progression.
Yukako Maeda, Shuichiro Umetsu, Eitaro Hiejima, Mitsuyoshi Suzuki, Itaru Iwama, Takeshi Kimura, Sonoko Kondo, Ayano Inui, Hiroki Kondou, Tatsuya Okamoto, Takashi Ito, Hiroyuki Shirahase, Kazushi Izawa, Takahiro Yasumi, Takeshi Kuwada, Masahiro Shiokawa, Hiroshi Seno, Junko Takita   +17 more
wiley   +1 more source

Hepatitis B surface antigen seroprevalence in Morocco (2000-2024): a systematic review and meta-analysis. [PDF]

BMC Infect Dis
Feindiri M, Kabbaj H, Salihoun M, Errabih I, Melloul M, Elfahime E, Seffar M.   +6 more
europepmc   +1 more source

Toward a Synthetic Data Revolution: Diffusion Model‐Enhanced Hepatocellular Carcinoma Prediction in Steatotic Liver Disease

Hepatology Research, EarlyView.
ABSTRACT Aim Steatotic liver disease (SLD) encompasses a heterogeneous spectrum with varying risks of hepatocellular carcinoma (HCC). Limited sample sizes limit the development of predictive models, particularly for rare outcomes. This study evaluated whether generative artificial intelligence (AI)‐based synthetic data augmentation can enhance HCC risk
Masaya Sato, Takuma Nakatsuka, Yuki Matsushita, Takuma Kaneko, Keisuke Mabuchi, Tomoharu Yamada, Kazuya Okushin, Tatsuya Minami, Yotaro Kudo, Satoshi Kodera, Kazuhiko Koike, Mitsuhiro Fujishiro, Ryosuke Tateishi   +12 more
wiley   +1 more source

Diagnostic performance of four hepatitis-B surface antigen conformité Européenne (CE) marked and one WHO prequalified rapid diagnostic tests in Uganda. [PDF]

PLoS One
Baliruno LN, Kato CD, Nakigozi H, Mujuzi H, Seremba E.   +4 more
europepmc   +1 more source