Results 231 to 240 of about 16,590,594 (260)

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, Volume 120, Issue 5, Page 1181-1194, November 2026.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

Serological and virological characterization of hepatitis B surface antigen-positive patients with or without Helicobacter pylori co-infection at the university of Gondar comprehensive specialized hospital, Northwest Ethiopia. [PDF]

BMC Infect Dis
Belayneh M, Tegegne BA, Tizazu AM, Yeshinew AG, Lemma M, Abay Z, Belyhun Y.   +6 more
europepmc   +1 more source

Plasmepsins as Antimalarial Drug Targets—Then, Now, and the Future

Medicinal Research Reviews, Volume 46, Issue 6, Page 1574-1602, November 2026.
ABSTRACT Malaria is a devastating disease caused by Plasmodium parasites. Plasmodium parasites express ten cathepsin D‐like aspartyl proteases, called plasmepsins (PMs). These PMs have diverse roles fulfill diverse functions throughout the parasite's lifecycle, though several exhibit functional redundancies. Among them, PMV, PMIV, and PMX are essential
Brad E. Sleebs
wiley   +1 more source

A US-Based Multi-Site Pilot to Screen Hepatitis B Surface Antigen-Positive Patients for Hepatitis D. [PDF]

J Viral Hepat
Li M, Hunt B, Balani B, Ogedegbe C, Gordon P, Hayden J, Glick N, Chang A, Wang S, Caponi M, Yarber-Cambron L, Bhat S, Ward T, Suryadevara M.   +13 more
europepmc   +1 more source

Vaccination Status and Influencing Factors of Delayed Vaccination in Toddlers Born to Hepatitis B Surface Antigen-Positive Mothers. [PDF]

Vaccines (Basel)
Gao J, Luan L, Zhu Y, Zhu J, Zhu Z, Gong T, Xu J, Liu N.   +7 more
europepmc   +1 more source

Community-Based Double Reflex Screening Reveals Widespread Hepatitis D Viremia Among Hepatitis B Surface Antigen Carriers in Pakistan. [PDF]

Cureus
Abbas M, Abbas Z, Sharif MY.
europepmc   +1 more source

Transcription of hepatitis B surface antigen shifts from cccDNA to integrated HBV DNA during treatment. [PDF]

J Clin Invest
Taddese M, Grudda T, Belluccini G, Anderson M, Cloherty G, Hwang HS, Mani M, Lo CM, Esrig N, Sulkowski MS, Sterling RK, Zhang Y, Ribeiro RM, Thomas DL, Thio CL, Balagopal A.   +15 more
europepmc   +1 more source

Mindray CL-900i assay: An effective assay for hepatitis B surface antigen screening with superior specificity. [PDF]

IJID Reg
Nasrallah GK, Younes S, Younes N, Nizamuddin PB, Alabdulmalek MA, Mohammad KN, Chaar DE, Elshaikh M, Abouassali MN, Karimeh IW, Ibrahim MA, Ali MM, Shaar IA, Louyin Z, Ammaranond P, Abu-Raddad LJ, Ismail A.   +16 more
europepmc   +1 more source

Trajectories and Decline of Serum Hepatitis B Surface Antigen Predict Outcomes in Patients With Chronic Hepatitis B. [PDF]

Open Forum Infect Dis
Hsu WF, Chen CF, Lai HC, Su WP, Wang HW, Chen SH, Huang GT, Peng CY.   +7 more
europepmc   +1 more source

Response to: Comment on ‘Comparing specificity and seroconversion sensitivity among major blood screening assays for human immunodeficiency virus and viral hepatitis’

Vox Sanguinis, EarlyView.
Monica Chaves, Martina Schaetzl, Florina Pessl   +2 more
wiley   +1 more source