Results 51 to 60 of about 470,387 (242)
Affinity Discrimination in B cells in Response to Membrane Antigen Requires Kinetic Proofreading [PDF]
arXiv, 2010 B cells signaling in response to antigen is proportional to antigen affinity, a process known as affinity discrimination. Recent research suggests that B cells can acquire antigen in membrane-bound form on the surface of antigen-presenting cells (APCs), with signaling being initiated within a few seconds of B cell/APC contact.
arxiv
Prediction, dynamics, and visualization of antigenic phenotypes of seasonal influenza viruses [PDF]
, 2015 Human seasonal influenza viruses evolve rapidly, enabling the virus population to evade immunity and re-infect previously infected individuals. Antigenic properties are largely determined by the surface glycoprotein hemagglutinin (HA) and amino acid substitutions at exposed epitope sites in HA mediate loss of recognition by antibodies.
arxiv +1 more source
Glycopeptide Composition of Hepatitis B Surface Antigen
Journal of General Virology, 1980 Three major polypeptides of hepatitis B surface antigen (HBsAg), with mol. wt. 22,000 (p22), 27,000 (p27) and 68,000 (p68), were separated by preparative SDS-PAGE. These three peptides as well as intact HBsAg were found to have almost identical amino acid compositions and carbohydrate was detected in p27 and p68 by PAS staining. Papain treatment of p68
Nakao Ishida +3 more
openaire +3 more sources
Formation of BCR Oligomers Provides a Mechanism for B cell Affinity Discrimination [PDF]
arXiv, 2012 B cells encounter antigen over a wide affinity range. The strength of B cell signaling in response to antigen increases with affinity, a process known as "affinity discrimination". In this work, we use a computational simulation of B cell surface dynamics and signaling to show that affinity discrimination can arise from the formation of BCR oligomers ...
arxiv
Nonequilibrium antigen recognition during infections and vaccinations [PDF]
arXiv, 2023 The immune response to an acute primary infection is a coupled process of antigen proliferation, molecular recognition by naive B cells, and their subsequent proliferation and antibody shedding. This process contains a fundamental problem: the recognition of an exponentially time-dependent antigen signal.
arxiv
Another oral antiviral treatment, but still far away from hepatitis B virus cure [PDF]
Clinical and Molecular Hepatology, 2021 Tai-Chung Tseng
doaj +1 more source
Integrating influenza antigenic dynamics with molecular evolution [PDF]
arXiv, 2013 Influenza viruses undergo continual antigenic evolution allowing mutant viruses to evade host immunity acquired to previous virus strains. Antigenic phenotype is often assessed through pairwise measurement of cross-reactivity between influenza strains using the hemagglutination inhibition (HI) assay.
arxiv
Journal of Community Health Research, 2012 Introduction: Intravenous drug users as a serious health problem in communities have economical and social effects as well as health and hygienic complications.
Abdolrasool Nikkhooy +2 more
doaj
BMC Research Notes, 2022 Objective Use of dried blood spots (DBS) for detection of hepatitis B virus (HBV) markers of infection has the potential to facilitate diagnosis of HBV infection especially in resource-limited countries.
Minami Kikuchi +5 more
doaj +1 more source
A dynamical model of the adaptive immune system: effects of cells promiscuity, antigens and B-B interactions [PDF]
, 2015 We analyse a minimal model for the primary response in the adaptive immune system comprising three different players: antigens, T and B cells. We assume B-T interactions to be diluted and sampled locally from heterogeneous degree distributions, which mimic B cells receptors' promiscuity.
arxiv +1 more source