Results 41 to 50 of about 97,023 (309)

Predictive value of HBeAg titer dynamics for HBsAg clearance in pediatric chronic hepatitis B

Frontiers in Pediatrics
IntroductionAchieving functional cure of chronic hepatitis B (CHB), characterized by the loss of HBV DNA and HBsAg, remains challenging in adults but demonstrates higher success rates in children.
Sukjin Hong, Jun Hyun Hwang, Keumoung Kim, Younghae Do, Naeun Kwak, Hyo Rim Suh, Sujin Choi, Ben Kang, Byung-Ho Choe   +8 more
doaj   +1 more source

Predominance of HBV Genotype B and HDV Genotype 1 in Vietnamese Patients with Chronic Hepatitis

Viruses, 2021
Hepatitis delta virus (HDV) coinfection will additionally aggravate the hepatitis B virus (HBV) burden in the coming decades, with an increase in HBV-related liver diseases.
Nghiem Xuan Hoan, Mirjam Hoechel, Alexandru Tomazatos, Chu Xuan Anh, Srinivas Reddy Pallerla, Le Thi Kieu Linh, Mai Thanh Binh, Bui Tien Sy, Nguyen Linh Toan, Heiner Wedemeyer, C.-Thomas Bock, Peter G. Kremsner, Christian G. Meyer, Le Huu Song, Thirumalaisamy P. Velavan   +14 more
doaj   +1 more source

NIBV Induces Incomplete Autophagy via AMPK‐TFEB, Causing Kidney Injury in Chicks

Advanced Science, EarlyView.
This study reveals that NIBV can inhibit the nuclear translocation of TFEB by suppressing the expression of AMPK, leading to the blockade of autophagolysosomal functions, in turn increasing NIBV replication and triggering severe kidney injury in chicks.
Cheng Huang, Yizhou Zeng, Yunfeng Chen, Zhengqing Li, Salma Mbarouk Omar, Shengwei Zhong, Ping Liu, Zhanhong Zheng, Gaofeng Cai, Xiaona Gao, Xiaoquan Guo   +10 more
wiley   +1 more source

HDV can constrain HBV genetic evolution in hbsag: Implications for the identification of innovative pharmacological targets [PDF]

, 2018
Chronic HBV + HDV infection is associated with greater risk of liver fibrosis, earlier hepatic decompensation, and liver cirrhosis hepatocellular carcinoma compared to HBV mono-infection.
Andreoni, Massimo, Angelico, Mario, Barlattani, Angelo, Battisti, Arianna, Bertoli, Ada, Cappiello, Giuseppina, Carioti, Luca, Ceccherini-Silberstein, Francesca, Colagrossi, Luna, Coppola, Nicola, De Cristofaro, Maria, DE SANCTIS, Giuseppe Maria, Fabeni, Lavinia, Fleury, Hervé, Iapadre, Nerio, Lanza, Alfonso Galeota, Lenci, Ilaria, Lichtner, Miriam, Malagnino, Vincenzo, Mari, Terenzio, Marignani, Massimo, Mastroianni, Claudio, Minichini, Carmine, Nebuloso, Elena, Pasquazzi, Caterina, Perno, Carlo-Federico, Piermatteo, Lorenzo, Salpini, Romina, Sarmati, Loredana, Scutari, Rossana, Spanò, Alberto, Stanzione, Maria, Stornaiuolo, Gianfranca, Svicher, Valentina, Trimoulet, Pascale   +34 more
core   +2 more sources

Serum hepatitis B surface antigen (HBsAg) kinetics in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B [PDF]

Hepatology International, 2012
Abstract Background We investigated the differences in HBsAg kinetics at different levels of viremia in hepatitis B e antigen (HBeAg)-negative chronic hepatitis B (CHB). Methods We compared HBsAg levels among HBeAg-negative CHB patients with persistently undetectable HBV ...
Seto, Wai-Kay, Wong, Danny Ka-Ho, Fung, James, Hung, Ivan Fan-Ngai, Yuen, John Chi-Hang, Tong, Teresa, Lai, Ching-Lung, Yuen, Man-Fung   +7 more
openaire   +2 more sources

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Serosurveillance of vaccine preventable diseases and hepatitis C in healthcare workers from Lao PDR. [PDF]

PLoS ONE, 2015
BACKGROUND AND AIMS:Healthcare workers (HCW) have an increased risk of exposure to infectious diseases and are a potential source of infections for their patients.
Antony P Black, Keooudomphone Vilivong, Phonethipsavanh Nouanthong, Chanthasone Souvannaso, Judith M Hübschen, Claude P Muller   +5 more
doaj   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Glycopeptide Composition of Hepatitis B Surface Antigen

Journal of General Virology, 1980
Three major polypeptides of hepatitis B surface antigen (HBsAg), with mol. wt. 22,000 (p22), 27,000 (p27) and 68,000 (p68), were separated by preparative SDS-PAGE. These three peptides as well as intact HBsAg were found to have almost identical amino acid compositions and carbohydrate was detected in p27 and p68 by PAS staining. Papain treatment of p68
H, Shiraishi, R, Shirachi, K, Akiyama, N, Ishida   +3 more
openaire   +2 more sources

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source