Results 21 to 30 of about 16,498,742 (308)

Programmable Nanobody-Targeting Chimeras Enable Intracellular Viral Protein Degradation. [PDF]

Adv Sci (Weinh)
Nab‐TAC enables targeted degradation of HBV surface antigen (HBsAg) in vivo. By fusing nanobody‐based recognition domains with programmable proteasome‐recruiting degradation signals, Nab‐TAC reduces HBsAg levels in a hydrodynamic HBV mouse model. ABSTRACT Chronic hepatitis B virus (HBV) infection remains a major global health challenge, largely because
Pan MY, Lee TH, Peng TN, Wu EY, Chiu YT, Chiu CC, Nguyen HV, Pao YS, Chao MH, Lee RK, Wu HC, Wang LH.   +11 more
europepmc   +2 more sources

Clinical performance of a new hepatitis B surface antigen quantitative assay with automatic dilution

Kaohsiung Journal of Medical Sciences, 2015
Hepatitis B virus surface antigen (HBsAg) levels reflect disease status and can predict the clinical response to antiviral treatment; however, the emergence of HBsAg mutant strains has become a challenge.
Ta-Wei Liu, Ming-Lun Yeh, Chung-Feng Huang, I.-Ling Lin, Jee-Fu Huang, Chia-Yen Dai, Yao-Li Chen, Wan-Long Chuang, Ming-Lung Yu   +8 more
doaj   +1 more source

Randomised controlled trial: effect of metformin add-on therapy on functional cure in entecavir-treated patients with chronic hepatitis B

Annals of Hepatology, 2022
Introduction and Objectives: Hepatitis B surface antigen (HBsAg) clearance, indicating functional cure or resolved chronic hepatitis B (CHB), remains difficult to achieve via nucleos(t)ide analogue monotherapy.
Wei Zhang, Yuan-Yuan Li, Qing-Hua Shang, Lin Qi, Mi-Mi Sun, Gang Chen, Yong An, Jing-Xin Li, Wang-Ping Jia, Zhong-An Sun, Hui-Bin Xu, Qing-Mei Gao, Li Tang, Xiao-Wen Wang, Ji-Yuan Zhang, Yi-Ming Mu, Fu-Sheng Wang   +16 more
doaj   +1 more source

Expression of Hepatocyte Hepatitis B Core Antigen and Hepatitis B Surface Antigen as a Marker in the Management of Chronic Hepatitis B Patients

Gut and Liver, 2017
Background/AimsWe aimed to clarify the association of hepatitis B surface antigen (HBsAg)/hepatitis B core antigen (HBcAg) with the disease status and treatment response in patients with chronic hepatitis B (CHB).Methods : We investigated 171 biopsy ...
Sun Young Yim, Tae Hyung Kim, Suh Sang Jun, Eun Sun Kim, Bora Keum, Yeon Seok Seo, Hyung Joon Yim, Yoon Tae Jeen, Hoon Jai Chun, Hong Sik Lee, Soon Ho Um, Chang Duck Kim, Nam Hee Won, Ho Sang Ryu   +13 more
doaj   +1 more source

Modulation of the CD8+-T-cell response by CD4+ CD25+ regulatory T cells in patients with Hepatitis B virus infection [PDF]

, 2005
CD4+ CD25+ regulatory T cells have been shown to maintain peripheral tolerance against self and foreign antigens. In this study we analyzed the effect of circulating CD4+ CD25+ T cells on CD8+-T-cell responses of patients with chronic and resolved ...
Gotto, J, Ornella Franzese, Antonio Bertoletti, Maini, Mk, Franzese, O., Williams, R., Adam J. Gehring, Gehring, A.J., Roger Williams, Gehring, Aj, Gotto, J., Bertoletti, A., Kennedy, P.T.F., Williams, R, Maini, M.K., Patrick T. F. Kennedy, Kennedy, Ptf, Jim Gotto, Mala K. Maini, FRANZESE, ORNELLA   +19 more
core   +1 more source

Seroprevalence of hepatitis B infection and associated risk factors among drug users in drop-in centers of Isfahan, Iran

International Journal of Preventive Medicine, 2018
Background: Scientists perceive drug users (DUs) as a high-risk population for hepatitis B virus (HBV) infection. Effective strategies aiming at the reduction of HBV infection can be depicted when its epidemiological status is clearly defined.
Roya Taleban, Mohammad Moafi, Behrooz Ataei, Majid Yaran, Zary Nokhodian, Nazila Kassaian, Peyman Adibi, Abbasali Javadi   +7 more
doaj   +1 more source

Persistence of antibody to hepatitis B surface antigen [PDF]

Journal of Clinical Microbiology, 1976
Sera from military personnel found to have antibodies to hepatitis B surface antigen (anti-HBS) in an epidemiological study of a hepatitis B outbreak were tested for persistence of that antibody 1 year later. Initially, 64% of the anti-HBS-positive sera reacted in passive hemagglutination tests with erythrocytes coated with hepatitis B surface antigen ...
G R, Irwin, A M, Allen, H E, Segal, M, Willhight, H, Cannon, F H, Top   +5 more
openaire   +2 more sources

The prevalence of hepatitis B virus markers among students of Shiraz University of Medical Sciences

Advanced Biomedical Research, 2021
Background: Protection against hepatitis B virus (HBV) is based on the presence of antibodies against hepatitis B surface antigen (HBsAg). Vaccination of newborns is the most effective means of prevention.
Razieh Dowran, Mahyar Malekzadeh, Tayyar Nourollahi, Bahador Sarkari, Jamal Sarvari   +4 more
doaj   +1 more source

Does limited virucidal activity of biocides include duck hepatitis B virucidal action? [PDF]

, 2012
BACKGROUND: There is agreement that the infectivity assay with the duck hepatitis B virus (DHBV) is a suitable surrogate test to validate disinfectants for hepatitis B virucidal activity.
Wutzler, Peter, Bust, Uwe, Peter Wutzler, Michael Schacke, Uwe Bust, Rabenau, Holger, Brigitte Glück, Holger F Rabenau, Glück, Brigitte, Andreas Sauerbrei, Sauerbrei, Andreas, Schacke, Michael   +11 more
core   +2 more sources

Identification of novel neutralizing determinants for protection against HCV

Hepatology, EarlyView., 2022
Identification of novel neutralizing determinants for protection against hepatitis C virus. Abstract Background and Aims HCV evasion of neutralizing antibodies (nAb) results in viral persistence and poses challenges to the development of an urgently needed vaccine.
Garazi P. Alzua, Anne F. Pihl, Anna Offersgaard, Rodrigo Velázquez‐Moctezuma, Carlos R. Duarte Hernandez, Elias H. Augestad, Ulrik Fahnøe, Christian K. Mathiesen, Henrik Krarup, Mansun Law, Jannick Prentoe, Jens Bukh, Judith M. Gottwein   +12 more
wiley   +1 more source