Results 211 to 220 of about 376,311 (300)

Hepatitis B Vaccine Refusal Trends in Washington, DC, Newborns, 2017-2022.

open access: yesJAMA Netw Open
Yang YT, Leslie TF, Delamater PL.
europepmc   +1 more source

Targeting Immune Checkpoints: Basic Signaling Pathways and Clinical Translation in Cancer Therapeutics

open access: yesMedComm – Oncology, Volume 4, Issue 3, September 2025.
Immune checkpoints in tumor immunotherapy. Ligand binding to the receptor inhibits immune cell function, promotes tumor cell immune escape, and suppresses the immune response. The pathways of action are VISTA‐IGSF11, TIM‐3‐Ceacam1, CD47‐SIRPα, CTLA‐4‐CD80/CD86, PD‐L1‐PD‐1, MHC‐1‐LILRB, and CD24 ‐ Siglec ‐10. There are also other immune checkpoints such
Han Sun   +10 more
wiley   +1 more source

Primary Progressive Multiple Sclerosis: New Therapeutic Approaches

open access: yesNeuropsychopharmacology Reports, Volume 45, Issue 3, September 2025.
Primary progressive MS affects 10%–15% of MS patients, causing irreversible neurological impairment. Drugs like ocrelizumab show promise, while high‐dose biotin, simvastatin, and coenzyme Q10 are under investigation. Gene therapy and stem cell treatments also show potential.
Morteza Rajabi   +8 more
wiley   +1 more source

Comparative analysis of the extent of protein–protein interactions in icosahedral viral capsids

open access: yesProtein Science, Volume 34, Issue 9, September 2025.
Abstract Nonenveloped viruses package, carry, and deliver their genomes to the targeted cells using protein shells known as capsids. The viral capsids come in different shapes and sizes, most exhibiting helical or icosahedral symmetries. Here, we analyzed 634 icosahedral capsids at high resolution (<4 Å) from 39 virus families with T‐numbers ranging ...
Noah J. Zimmerman   +2 more
wiley   +1 more source

Retrospective Cross‐Sectional Study of Occupational Infection Risk With Zoonotic Pathogens in Austrian Veterinary Practitioners in the Year 2022

open access: yesVeterinary Medicine and Science, Volume 11, Issue 5, September 2025.
• Vaccination rates against rabies and TBEV and accordingly the respective seroprevalence rates exceed 90% among Austrian veterinary practitioners. • The prevalence of antibodies against HEV and the colonisation with MRSA increases with the age of the study participants from 6.2%/6.2% in the youngest age group to 23.3%/21.9% in the oldest group. • MRSA
Tatjana Sattler   +9 more
wiley   +1 more source

Understanding the Enigmatic Dance of Immune‐Mediated Viral Infections and Their Pathogenetic Mechanisms

open access: yesVeterinary Medicine and Science, Volume 11, Issue 5, September 2025.
This graphical representation illustrates the multifaceted nature of the immune response in viral infections, demonstrating both its protective and potentially harmful aspects. While a properly regulated immune reaction facilitates viral clearance and promotes general recovery, an overly robust or misdirected response—exemplified by Type III or Type IV
Muhammed Cesim Karabulut   +1 more
wiley   +1 more source

The ‘Informed Matter’ of Gay and Bisexual Men's (Potential) Use of HIV Antiretrovirals to Prevent COVID‐19

open access: yesSociology of Health &Illness, Volume 47, Issue 7, September 2025.
ABSTRACT In 2020, there were reports that HIV antiretrovirals, specifically the combination tenofovir disoproxil fumarate and emtricitabine (TDF/FTC), had therapeutic potential for COVID‐19. In the context of scant empirical evidence at the time to confirm such an effect, we sought to understand the ways that gay and bisexual men (GBM) made sense of ...
Daniel Storer   +4 more
wiley   +1 more source

Clinical Validation of Loop‐Mediated Isothermal Amplification Assays for the Rapid Detection of Neisseria gonorrhoeae and Chlamydia trachomatis

open access: yesMicrobial Biotechnology, Volume 18, Issue 9, September 2025.
Neisseria gonorrhoeae and Chlamydia trachomatis are major causes of sexually transmitted infections globally. We developed LAMP assays achieving 96% sensitivity for gonorrhoea and 95% for chlamydia (with extraction), and ≥ 98% specificity. These assays offer a promising diagnostic tool, particularly in high‐burden, resource‐limited settings.
Yasaman Ahmadi   +4 more
wiley   +1 more source

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