Results 231 to 240 of about 95,168 (297)

The Role of Viral and Bacterial Infections in the Etiology of Behçet's Disease

open access: yesJournal of Clinical Laboratory Analysis, Volume 40, Issue 1, January 2026.
Bacterial and viral pathogens may play a key role in Behçet's disease (BD) pathogenesis by triggering autoimmunity, molecular mimicry, or microbiome disruption. These infectious agents could initiate inflammatory pathways, contributing to BD's diverse clinical manifestations.
Mohsen Moghoofei   +4 more
wiley   +1 more source

Genetically Validated Immune Susceptibility Markers for Crohn's Disease: A Multi‐Omics Mendelian Randomization Analysis

open access: yesJGH Open, Volume 10, Issue 1, January 2026.
ABSTRACT Background Crohn's disease (CD) is a chronic inflammatory bowel disorder with a multifactorial genetic, immune, and environmental basis, yet robustly validated therapeutic targets remain limited. We applied a multi‐omics Mendelian randomization (MR) framework and colocalization to prioritize genetically supported immune susceptibility loci for
Zeyang Li
wiley   +1 more source

Research priorities for advanced HIV disease in Latin America and the Caribbean region: a modified Delphi study

open access: yesJournal of the International AIDS Society, Volume 29, Issue 1, January 2026.
Abstract Introduction Advanced HIV disease (AHD) remains a leading cause of mortality in Latin America and the Caribbean (LAC), driven by late diagnosis, treatment gaps and structural barriers, particularly among key populations and children. Persistent disparities in healthcare access, stigma, and limited health system capacity highlight the need for ...
Evelina Chapman   +7 more
wiley   +1 more source

Mapping protein–protein interactions by mass spectrometry

open access: yesMass Spectrometry Reviews, Volume 45, Issue 1, Page 69-106, January/February 2026.
Abstract Protein–protein interactions (PPIs) are essential for numerous biological activities, including signal transduction, transcription control, and metabolism. They play a pivotal role in the organization and function of the proteome, and their perturbation is associated with various diseases, such as cancer, neurodegeneration, and infectious ...
Xiaonan Liu   +4 more
wiley   +1 more source

Case Report: Compound Heterozygous SCNN1B Mutations Causing Pseudohypoaldosteronism Type 1B2 in Neonatal Twins

open access: yesMolecular Genetics &Genomic Medicine, Volume 14, Issue 1, January 2026.
First Chinese neonatal cases of systemic PHA1B from novel compound‐heterozygous SCNN1B variants (c.585+2T>C; c.1544T>C) presented with life‐threatening hyperkalemia and hyponatremia unresponsive to steroids. Early genetic testing enabled targeted sodium supplementation and potassium‐binding therapy, normalizing electrolytes and underscoring SCNN1B ...
Zhiping Wang, Lijuan Long, Hongjuan Bi
wiley   +1 more source

Introducing adjuvant-loaded particulate hepatitis B core antigen as an alternative therapeutic hepatitis B vaccine component. [PDF]

open access: yesJHEP Rep
Su J   +11 more
europepmc   +1 more source

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