Results 71 to 80 of about 133,468 (309)

Comorbidities in aging patients with sickle cell disease. [PDF]

, 2018
Sickle cell disease (SCD) in general and sickle cell anemia in particular is a highly complex disorder both at the molecular and clinical levels. Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing ...
Ballas, Samir K.
core   +2 more sources

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

Recombinant Flag-tagged E1E2 glycoproteins from three hepatitis C virus genotypes are biologically functional and elicit cross-reactive neutralizing antibodies in mice [PDF]

, 2018
Hepatitis C virus (HCV) is a globally disseminated human pathogen for which no vaccine is currently available. HCV is highly diverse genetically and can be classified into 7 genotypes and multiple sub-types. Due to this antigenic variation, the induction
Bieńkowska-Szewczyk, Krystyna, Chmielewska, Alicja, Krapchev, Vasil B., Patel, Arvind H., Rychłowska, Malgorzata, Zimmer, Karolina   +5 more
core   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

A Multivalent mRNA Therapeutic Vaccine Exhibits Breakthroughs in Immune Tolerance and Virological Suppression of HBV by Stably Presenting the Pre-S Antigen on the Cell Membrane

Pharmaceutics
Background/Objectives: In chronic hepatitis B infection (CHB), the hepatitis B surface antigen (HBsAg) continuously exhausts the hepatitis B surface antibody (HBsAb), which leads to the formation of immune tolerance.
Shang Liu, Jie Wang, Yunxuan Li, Muhan Wang, Pei Du, Zhijie Zhang, Wenguo Li, Rongchen Sun, Mingtao Fan, Meijia Yang, Hongping Yin   +10 more
doaj   +1 more source

Problems of the Current Vaccination Strategy against Hepatitis B

Эпидемиология и вакцинопрофилактика, 2017
Accumulation of escape mutants of hepatitis B virus (HBV) occur in the many countries at the conditions of wide-scale vaccination against hepatitis B, especially among vaccinated children.
M. V. Konopleva, V. N. Borisova, T. A. Semenenko, M. A. Krymskij   +3 more
doaj   +1 more source

Vaccination with DNA plasmids expressing Gn coupled to C3d or alphavirus replicons expressing Gn protects mice against rift valley fever virus [PDF]

, 2010
Background: Rift Valley fever (RVF) is an arthropod-borne viral zoonosis. Rift Valley fever virus (RVFV) is an important biological threat with the potential to spread to new susceptible areas. In addition, it is a potential biowarfare agent. Methodology/
A Jouan, A Zaki, B Botros, BH Bird, BS Peters, CS Schmaljohn, CS Schmaljohn, Daniel G. Bausch, DB Wallace, DV Lim, FR Toapanta, FR Toapanta, G Lorenzo, GF Meadors 3rd, H Caplen, I Watanabe, J Lubroth, J Meegan, J Naslund, J Naslund, JA Mitchell, JF Bower, JF Bower, JR Haynes, JT van Oirschot, K Keegan, K Spik, KA Hubbard, M Mkrtichyan, MA Kutzler, Mark T. Heise, MT Heise, N Lagerqvist, Nitin Bhardwaj, P Hunter, P Jansen van Vuren, P Nguku, P Pittman, P Pushko, P Vialat, PR Pittman, PW Dempsey, R Gorchakov, R Gorchakov, R Randall, RJ Daubney, S Won, SA Kamal, SR Gerrard, SR Gerrard, T Shoemaker, TA Madani, TD Green, Ted M. Ross, TM Pertmer, TM Pertmer, TM Ross, TM Ross, UB Balasuriya   +58 more
core   +4 more sources

Case‐Based Immunology: B Cells and Systemic Sclerosis Interstitial Lung Disease

Arthritis &Rheumatology, EarlyView.
Interstitial lung disease (ILD) is an important complication of systemic sclerosis (SSc), with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to US Food and Drug Administration–approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of ILDs of other systemic autoimmune
Nina Goldman, Voon Ong, Christopher P. Denton   +2 more
wiley   +1 more source

Completion of multiple-dose travel vaccine series and the availability of pharmacist immunizers: A retrospective analysis of administrative data in Alberta, Canada.

PLoS ONE, 2019
Pharmacists in a number of countries are being trained in the administration of injections with the aim of improving access and adherence to vaccinations.
Sherilyn K D Houle, Dean T Eurich
doaj   +1 more source

The Update, February 13, 2012 [PDF]

, 2012
The Update is a bi-weekly web newsletter published by the Iowa Department of Public Health's Bureau of Family Health. It is posted the second and fourth week of every month, and provides useful job resource information for departmental health care ...

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