Results 151 to 160 of about 607,237 (310)

Transient Transfection of Rolling‐Circle Amplified DNA in Biomanufacturing‐Relevant Mammalian Cell Lines: A Comparison of Transfection Conditions for Optimal Protein Expression

open access: yesBiotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Rolling‐circle amplification (RCA) is a completely synthetic and rapid mechanism for scaling‐up bulk DNA that eliminates requirements for large‐scale bacterial fermentation. Several reports have described the surprising ability of large unprocessed (hyperbranched) rolling circle‐amplified DNA (RCA DNA) to effectively transfect cultured cells ...
Evelina Loghin   +8 more
wiley   +1 more source

Risk of liver cancer in patients with hepatitis B or C [PDF]

open access: yes, 2011
Key Messages1. Among hepatitis B virus carriers, infection with genotype C significantly increases the risk of developing hepatocellular cancer compared to those without this genotype.2.
Huang, JQ   +4 more
core  

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić   +7 more
wiley   +1 more source

Design Space Assessment of Virus Inactivation in Plasma‐Derived Matrices Establishes a Single Detergent Alternative to TX‐100‐Containing Mixes

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT The detergent Triton X‐100 (TX‐100) is a typical component of solvent/detergent (S/D) mixes applied for virus inactivation steps of biomanufacturing processes, yet environmentally unfavorable properties have led to restrictions on its use. Deviron 13‐S9 has recently been described as an eco‐friendly TX‐100 alternative, with powerful virus ...
Johanna Kindermann   +3 more
wiley   +1 more source

Epidemiology of viral hepatitis in Sudan

open access: yesClinical and Experimental Gastroenterology, 2008
Hatim MY MudawiDepartment of Internal Medicine, Faculty of Medicine, University of Khartoum, Khartoum, SudanAbstract: Hepatitis virus infections are the most common cause of liver disease worldwide.
Hatim MY Mudawi
doaj  

Vacunas de las hepatitis viricas: de la A a la E [PDF]

open access: yes, 2011
En los últimos cuarenta años el desarrollo del conocimiento de los virus causantes de hepatitis ha sido impresionante y hoy DIAGNOSTICAMOS al menos cinco tipos de virus, dos de transmisión oral y tres de transmisión parenteral y sexual( Figura 1 ).Estos ...
Rodrigo Gómez, José Manuel
core  

Dried blood spot analysis in antidoping: Technical challenges, analytical advances, and future perspectives

open access: yesBulletin of the Korean Chemical Society, EarlyView.
Dried blood spot (DBS) analysis enables minimally invasive blood collection with strong analyte stability and simplified logistics, supporting anti‐doping applications beyond traditional matrices. Recent advances address hematocrit, volume variability, and matrix effects while expanding coverage to steroid esters, World Anti‐Doping Agency‐listed ...
Jihyun Yoon   +4 more
wiley   +1 more source

Variants of Hepatitis B Virus [PDF]

open access: yesVox Sanguinis, 1992
T J, Harrison, A J, Zuckerman
openaire   +2 more sources

ProTides for Antiviral Activity Beyond Liver Cells

open access: yesChemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel   +5 more
wiley   +1 more source

Optimization of a Method for Detecting Single copies of Hepatitis B Virus DNA using CRISPR/Cas systems

open access: yesЭпидемиология и вакцинопрофилактика
Relevance. Hepatitis B virus (HBV) is the etiologic agent of acute and chronic hepatitis B in humans. WHO recommends the use of sensitive laboratory assays based on nucleic acid amplification methods to detect HBV DNA.
M. A. Tyumentseva   +3 more
doaj   +1 more source

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