Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation
Advanced Science, EarlyView.Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu +9 more
wiley +1 more source
Advanced Science, EarlyView.It is shown that obesity is associated with increases in hepatic METTL14 and m6A methylation of G6pc transcript. YTHDF1 and YTHDF3 bind to m6A‐marked G6pc mRNA to increase its synthesis. Hepatocyte‐specific deletion of Mettl14 decreases G6pc m6A methylation, G6pc biosynthesis, and G6pc‐mediated gluconeogenesis, alleviating glucose metabolic defects in ...
Qiantao Zheng +6 more
wiley +1 more source
, 2012 Asian immigrants to the U.S. have an increased prevalence of hepatitis B virus (HBV) infection compared to native born individuals; an estimated 10 percent of Chinese immigrants are infected with HBV.
Acorda, Elizabeth +3 more
core
Hepatitis B Virus Double Mutations is There Any Role in Pathogenesis of Hepatocellular Carcinoma in Young Patients [PDF]
, 2009 Background: The incidence of hepatocellular carcinoma (HCC) below age 40 years old in our institution were relatively high compared with other institutions in Asia.
Christine, G. (Griscalia) +5 more
core
Recent Advances in mRNA Delivery Systems for Cancer Therapy
Advanced Science, EarlyView.This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang +9 more
wiley +1 more source
Persistence of hepatic hepatitis B virus after serological clearance of HBsAG with autologous peripheral stem cell transplantation [PDF]
, 1997 Delayed clearance of hepatitis B surface antigen was previously reported in a 38 year old woman after high dose chemotherapy with autologous peripheral blood stem cell rescue.
Lau, GKK +4 more
core +1 more source
Recent Advances in Xenes Based FET for Biosensing Applications
Advanced Science, EarlyView.Xenes (monoelemental 2D materials like graphene, phosphorene, tellurene) enable ultrasensitive FET (Field‐Effect Transistor) biosensors due to their tunable bandgap, high carrier mobility, and large surface area. Advances in synthesis (CVD, MBE) and functionalization allow detection of DNA/RNA (via CRISPR‐Cas systems), proteins, small molecules, and ...
Huide Wang +9 more
wiley +1 more source
Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR‐Cas12a System
Advanced Science, EarlyView.This study introduces a novel approach combining molecular dynamics simulations and neural network modeling to predict the Cas12a trans‐cleavage activity. By integrating sequence and molecular interaction features, prediction accuracy is enhanced, and identify key features affecting Cas12a trans‐cleavage activity.
Zhihao Yao +7 more
wiley +1 more source
Снижение заболеваемости в Узбекистане вирусными гепатитами в и с — составляющая профилактики гепатоцеллюлярной карциномы [PDF]
, 2009 Представлена многолетняя динамика (1986–2006 гг.) заболеваемости вирусным гепатитом В, а также данные о распространенности в Республике Узбекистан вирусного гепатита С.
Исламбекова, З.А.
core
Routine use of counter-immunoelectrophoresis test for detecting antibody to hepatitis B virus core antigen. [PDF]
, 1978 Rebecca Freeman, M.H. Hambling
openalex +1 more source