Results 41 to 50 of about 897,217 (308)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Infection with hepatitis B virus carrying novel pre-S/S gene mutations in female siblings vaccinated at birth: two case reports

Journal of Medical Case Reports, 2010
Introduction After the initiation of a mass hepatitis B vaccination program in Taiwan, the prevalence of hepatitis B virus infection has declined progressively.
Yeh Christopher S-H, Lai Ming-Wei, Yeh Chau-Ting   +2 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Evaluating vertical transmission of sexually transmitted infections to newborns

Journal of Infection in Developing Countries, 2021
Introduction: Sexually transmitted infections are among the most frequent infections affecting pregnant women. We assessed the transmission of hepatitis B virus, human immunodeficiency virus type 1 and Treponema pallidum to newborns from infected ...
Dinamene Oliveira, João Piedade, Rita Castro, Ângela Lopes, Maria do Rosário Martins, Filomena Pereira   +5 more
doaj   +1 more source

Management of hepatitis B virus [PDF]

Journal of Antimicrobial Chemotherapy, 2008
Hepatitis B is a common problem worldwide with serious sequelae. Despite the explosion of new agents, management has grown even more complicated. The treatment paradigm is evolving from limited therapy to lifelong viral suppression in several populations.
Nidhi A, Singh, Nancy, Reau
openaire   +2 more sources

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Immunological response of Hepatitis B Virus Surface Antigen in HBV Mono and HBV/HDV Co-infection

Pakistan Journal of Medicine and Dentistry
Hepatitis B virus (HBV) can evolve under selection pressure exerted by drugs and host immunity, resulting in the accumulation of escape mutations that can affect the drug or the immune activity.
Mehwish Sajjad, Shaheen Kouser, Yusra Shafique, Fatima Arshad   +3 more
doaj   +1 more source

A convoluted path to the diagnosis of hepatocellular carcinoma in a resource-limited setting

SAGE Open Medical Case Reports, 2023
Worldwide, chronic hepatitis B virus infection remains the main aetiology of hepatocellular carcinoma, while human immunodeficiency virus may hasten the evolution of hepatocellular carcinoma in those co-infected with hepatitis B virus/human ...
WC Sithole, S Pillay, B Mbanjwa, N Magula   +3 more
doaj   +1 more source

RNAi-Based Treatment of Chronically Infected Patients and Chimpanzees Implicates Integrated Hepatitis B Virus DNA as a Source of HBsAg

Science Translational Medicine, 2017
The hepatitis B virus surface antigen, key to maintaining chronic infection, is expressed from viral DNA integrated into the host chromosome. How hepatitis hangs around Hepatitis B virus (HBV) infects the liver, and chronic infection can lead to ...
C. Wooddell, M. Yuen, H. Chan, R. Gish, S. Locarnini, D. Chavez, C. Ferrari, B. Given, J. Hamilton, S. Kanner, Ching‐lung Lai, J. Lau, T. Schluep, Zhao Xu, R. Lanford, D. Lewis   +15 more
semanticscholar   +1 more source