Results 31 to 40 of about 607,237 (310)

An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes

Emerging Microbes and Infections
Type I interferons (IFN-Is) have key roles in immune defense and treatments for various diseases, including chronic hepatitis B virus (HBV) infection.
Yumeng Li, Asha Ashuo, Menghan Hao, Yaming Li, Jianyu Ye, Jiangxia Liu, Ting Hua, Zhong Fang, Jianhua Li, Zhenghong Yuan, Jieliang Chen   +10 more
doaj   +1 more source

Interferon-α for Immune Modulation in Chronic Hepatitis B Toward Functional Cure

Viruses
Chronic hepatitis B (CHB) remains a major global health challenge, largely due to the persistence of covalently closed circular DNA (cccDNA) and impaired host immunity.
Asha Ashuo, Jia Liu, Zhenghong Yuan, Jieliang Chen   +3 more
doaj   +1 more source

Prevalence and risk factors of hepatitis B and C virus infections in an impoverished urban community in Dhaka, Bangladesh [PDF]

, 2010
Viral hepatitis is a serious global public health problem affecting billions of people globally, and both hepatitis B virus (HBV) and hepatitis C virus (HCV) infections are rapidly spreading in the developing countries including Bangladesh due to the ...
Hasan Ashraf, Nur H Alam, Christian Rothermundt, Abdullah Brooks, Pradip Bardhan, Lokman Hossain, Mohammed A Salam, Mohammed S Hassan, Christoph Beglinger, Niklaus Gyr   +9 more
core   +2 more sources

A novel monoclonal antibody targeting a conserved inner region of the hepatitis B virus envelope enables broad detection of immune escape variants

Virus Research
The detection of hepatitis B surface antigen (HBsAg) is fundamental for the diagnosis of chronic hepatitis B (CHB). However, current diagnostic assays that rely on antibodies targeting the conformational “a” determinant of HBsAg are frequently ...
Yansong Chen, Xinyu Zhang, Asha Ashuo, Zhong Fang, Wuhui Song, Jiangxia Liu, Jieliang Chen, Yaming Li, Zhenghong Yuan   +8 more
doaj   +1 more source

Leprosy and hepatitis B coinfection in southern Brazil

Brazilian Journal of Infectious Diseases, 2014
To investigate the association of leprosy with hepatitis B virus (HBV) infection, as yet unknown for South Brazil, we assessed hepatitis B virus coinfection in 199 South Brazilian leprosy patients (119 lepromatous, 15 tuberculoid, 30 borderline, 12 ...
Cleverson Leitão, Denis Ueda, Anna Carolina de Moraes Braga, Angelica B.W. Boldt, Iara J.T. Messias-Reason   +4 more
doaj   +1 more source

The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran: A population-based study [PDF]

, 2009
Background: Hepatitis B virus infection is a very common cause of chronic liver disease worldwide. It is estimated that 3 of Iranians are chronically infected with hepatitis B virus.
Abolghasemi, H., Amini-Kafiabad, S., Assari, S., Hosseini, M.R., Jamali, J., Maghsudlu, M., Malekzadeh, R., Merat, S., Nouraie, M., Pourshams, A., Radmard, A.R., Rezvan, H., Zaer-Rezaii, H., Zeid-Abadi-Nejhad, M.   +13 more
core  

Hepatitis B virus and Hepatocarcinogenesis

Annals of Hepatology, 2008
Hepatitis B viral (HBV) infection is the commonest cause of hepatocellular carcinoma. HBV DNA is the most important predictor of hepatocarcinogenesis in HB surface antigen positive patients. We reviewed the mechanism of hepatocarcinogenesis on molecular level with a special emphasis on the role of X-protein. Hepatitis B X-protein communicates with host
Faisal Azam, Anastasios Koulaouzidis
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Schistosomiasis japonicum diagnosed on liver biopsy in a patient with hepatitis B co-infection: a case report [PDF]

, 2014
Introduction Chronic hepatitis B virus and schistosomiasis are independently associated with significant mortality and morbidity worldwide. Despite much geographic overlap between these conditions and no reason why co-infection should not exist, we ...
Andrews, Tim, Beadsworth, Mike BJ, Michie, Kirsten, Miller, Alastair RO, Nsutebu, Emmanuel F, Parris, Victoria, Squire, Bertie   +6 more
core   +3 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source