Results 21 to 30 of about 458,398 (305)

Augmented epigenetic repression of hepatitis B virus covalently closed circular DNA by interferon-α and small-interfering RNA synergy

mBio
The persistence of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) is a key obstacle for HBV cure. This study aims to comprehensively assess the effect of interferon (IFN) and small-interfering RNA (siRNA) combination on the cccDNA ...
Kongying Hu, Wenjing Zai, Mingzhu Xu, Haiyu Wang, Xinluo Song, Chao Huang, Jiangxia Liu, Juan Chen, Qiang Deng, Zhenghong Yuan, Jieliang Chen   +10 more
doaj   +1 more source

An extracellular humanized IFNAR immunocompetent mouse model for analyses of human interferon alpha and subtypes

Emerging Microbes and Infections
Type I interferons (IFN-Is) have key roles in immune defense and treatments for various diseases, including chronic hepatitis B virus (HBV) infection.
Yumeng Li, Asha Ashuo, Menghan Hao, Yaming Li, Jianyu Ye, Jiangxia Liu, Ting Hua, Zhong Fang, Jianhua Li, Zhenghong Yuan, Jieliang Chen   +10 more
doaj   +1 more source

Leprosy and hepatitis B coinfection in southern Brazil

Brazilian Journal of Infectious Diseases, 2014
To investigate the association of leprosy with hepatitis B virus (HBV) infection, as yet unknown for South Brazil, we assessed hepatitis B virus coinfection in 199 South Brazilian leprosy patients (119 lepromatous, 15 tuberculoid, 30 borderline, 12 ...
Cleverson Leitão, Denis Ueda, Anna Carolina de Moraes Braga, Angelica B.W. Boldt, Iara J.T. Messias-Reason   +4 more
doaj   +1 more source

Interferon-α for Immune Modulation in Chronic Hepatitis B Toward Functional Cure

Viruses
Chronic hepatitis B (CHB) remains a major global health challenge, largely due to the persistence of covalently closed circular DNA (cccDNA) and impaired host immunity.
Asha Ashuo, Jia Liu, Zhenghong Yuan, Jieliang Chen   +3 more
doaj   +1 more source

The Evaluation of HBV-DNA Levels In Patients who Had Lost Hbsag After Recovery From Hepatitis B Virus Infection

Viral Hepatitis Journal, 2012
Objective:The risk of transmitting hepatitis B virus has been reported to continue in the blood of people with loss of HBsAg after recovery from hepatitis B virus infection.
Vicdan KÖKSALDI MOTOR, Aysel KOCAGÜL ÇELİKBAŞ, Nurcan BAYKAM, Şebnem EREN GÖK, Başak DOKUZOĞUZ   +4 more
doaj   +1 more source

Drug-related mutational patterns in hepatitis B virus (HBV) reverse transcriptase proteins from Iranian treatment-Naïve chronic HBV patients [PDF]

, 2013
Background: Immunomodulators and Nucleotide analogues have been used globally for the dealing of chronic hepatitis B virus (HBV) infection. However, the development of drug resistance is a major limitation to their long-term effectiveness.
Abedi, F., Alavian, S.M., Ataei, B., Azad, T.M., Daram, M., Fazeli, Z., Ghamari, S., Goodarzi, Z., Jazayeri, S.M., Judaki, M.A., Kalantari, E., Karimzadeh, H., Keyvani, H., Khedive, A., Mahabadi, M., Mahmoodi, M., Malekzadeh, R., Mansour-Ghanaei, F., Montazeri, G., Moradi, A., Nejatizadeh, A., Norouzi, M., Pourhosseingholi, M.A., Rafatpanah, H., Ramezani, F., Saberfar, E., Saberfiroozi, M., Samimirad, K., Sanei-Moghaddam, I., Sarizadeh, G., Sayad, B., Somi, M.H., Yaran, M., Ziee, M.   +33 more
core   +1 more source

A novel monoclonal antibody targeting a conserved inner region of the hepatitis B virus envelope enables broad detection of immune escape variants

Virus Research
The detection of hepatitis B surface antigen (HBsAg) is fundamental for the diagnosis of chronic hepatitis B (CHB). However, current diagnostic assays that rely on antibodies targeting the conformational “a” determinant of HBsAg are frequently ...
Yansong Chen, Xinyu Zhang, Asha Ashuo, Zhong Fang, Wuhui Song, Jiangxia Liu, Jieliang Chen, Yaming Li, Zhenghong Yuan   +8 more
doaj   +1 more source

Long-Term Persistent GBV-B Infection and Development of a Chronic and Progressive Hepatitis C-Like Disease in Marmosets [PDF]

, 2011
It has been shown that infection of GB virus B (GBV-B), which is closely related to HCV, develop acute self-resolving hepatitis in tamarins. In this study we sought to examine longitudinally the dynamics of viral and immunological status following GBV-B
Yuki Iwasaki, Ken-ichi Mori, Koji Ishii, Noboru Maki, Sayuki Iijima, Tomoyuki Yoshida, Sachi Okabayashi, Yuko Katakai, Young-Jung Lee, Akatsuki Saito, Hiromi Fukai, Nobuyuki Kimura, Naohide Ageyama, Sayaka Yoshizaki, Tetsuro Suzuki, Yasuhiro Yasutomi, Tatsuo Miyamura, Mari Kannagi, Hirofumi Akari   +18 more
core   +1 more source

Sero-prevalence and risk factors for hepatitis B virus infection among health care workers in a tertiary hospital in Uganda [PDF]

, 2010
BACKGROUND: Hepatitis B virus (HBV) infection is a global public health challenge. Prevalence of current hepatitis B virus infection in the general population in Uganda is about 10%.
Abdhalah K Ziraba, Alice Namale, Caroline W Wainaina, Harriet Mayanja-Kizza, Josephine Bwogi   +4 more
core   +3 more sources

Immunoprophylaxis to limit a hepatitis B epidemic among women undergoing in vitro fertilization [PDF]

, 1991
Women (175) who participated in an in vitro fertilization (IVF) programme were possibly exposed to hepatitis B virus. Later it became evident that 79 women had a hepatitis B infection, 49 were exposed but not infected and 47 were not exposed. Hepatitis B
Grosheide, P.M. (Pia Maria), Heijtink, R.A. (Rudolf), Osand, H.C. (H.) van, Schalm, S.W. (Solko)   +3 more
core   +5 more sources