Results 61 to 70 of about 1,015,430 (313)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Highly Specific and Rapid Detection of Hepatitis C Virus Using RT-LAMP-Coupled CRISPR–Cas12 Assay [PDF]

, 2022
Nang Kham-Kjing, Nicole Ngo‐Giang‐Huong, Khajornsak Tragoolpua, Woottichai Khamduang, Sayamon Hongjaisee   +4 more
openalex   +1 more source

Non cell autonomous upregulation of CDKN2 transcription linked to progression of chronic hepatitis C disease [PDF]

, 2013
Chronic hepatitis C virus infection (C-HC) is associated with higher mortality arising from hepatic and extrahepatic disease. This may be due to accelerated biological aging; however, studies in C-HC have thus far been based solely on telomere length as ...
Barclay, Stephen, McGuinness, Dagmara, McLauchlan, John, Mills, Peter R., Patel, Arvind H., Robinson, Mark W., Shiels, Paul G., Swann, Rachael   +7 more
core   +2 more sources

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Rapid Treatment Initiation for Hepatitis C in Young People Who Inject Drugs: The Seek, Test, and Rapid Treatment Randomized Trial [PDF]

, 2022
Benjamin Eckhardt, Shashi N. Kapadia, Pedro Mateu‐Gelabert, Melinda Pai, Chunki Fong, Yesenia Aponte-Meléndez, Kristen Marks   +6 more
openalex   +1 more source

Distinct cytokine patterns in Occult Hepatitis C and Chronic Hepatitis C Virus Infection [PDF]

, 2011
Background & Aim: The immunopathogenesis of chronic hepatitis C virus (HCV) infection is a matter of great controversy. The imbalance of T-helper lymphocyte cell cytokine production was believed to play an important pathogenic role in ...
Azza Azza Abdel-Aziz, Mohamed Abd-elmaksoud, Mona Elhadidy, Nashwa Abousamra, Nasser Mousa, Yahia Gad   +5 more
core   +1 more source

Clinical Outcomes of Patients Within the Rheumatoid Arthritis Care Pathway Cohort at a Tertiary Care Integrated Delivery Network: A Comparison to Usual Care

Arthritis Care &Research, EarlyView.
Objective We aimed to compare clinical outcomes between patients in the Allegheny Health Network rheumatoid arthritis (RA) care pathway and patients receiving usual care. Methods The care pathway initiative implements guideline‐based best practice alongside multidisciplinary team‐based care.
Tarun Sharma, Tyson S. Barrett, Teigan Dwyer, Nancy Campbell, Jessica Heintzinger, Ellen Kraemer, Adam Dore, Susan Manzi   +7 more
wiley   +1 more source

An inactivated SARS-CoV-2 vaccine based on a Vero cell culture-adapted high-titer virus confers cross-protection in small animals

Scientific Reports
Rapidly waning immunity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) requires continued global access to affordable vaccines. Globally, inactivated SARS-CoV-2 vaccines have been widely used during the SARS-CoV-2 pandemic.
Anna Offersgaard, Carlos R. Duarte Hernandez, Yuyong Zhou, Zhe Duan, Karen Anbro Gammeltoft, Katrine T. Hartmann, Ulrik Fahnøe, Pavel Marichal-Gallardo, Garazi Peña Alzua, Alexander P. Underwood, Christina Sølund, Nina Weis, Jesper Hansen Bonde, Jan P. Christensen, Gabriel K. Pedersen, Henrik Elvang Jensen, Kenn Holmbeck, Jens Bukh, Judith Margarete Gottwein   +18 more
doaj   +1 more source

Rad51 Interacts with Non-structural 3 Protein of Hepatitis C Virus and Regulates Viral Production

Frontiers in Microbiology, 2017
Hepatitis C virus (HCV) is a leading cause of chronic liver disease affecting over 170 million people worldwide. Chronic infection with HCV progresses to liver fibrosis, cirrhosis, and hepatocellular carcinoma.
Kidong Son, Kidong Son, Kidong Son, Tram T. T. Nguyen, Tram T. T. Nguyen, Jae-Woong Choi, Jae-Woong Choi, Long V. Pham, Long V. Pham, Trang T. D. Luong, Trang T. D. Luong, Yun-Sook Lim, Soon B. Hwang, Soon B. Hwang   +13 more
doaj   +1 more source

Clinical Conditions Associated With a High Antinuclear Antibody Titer in Individuals Without Autoimmune Disease

Arthritis Care &Research, EarlyView.
Objective Antinuclear antibodies (ANAs) are present at high titers in 2% of the general population, but their clinical significance in individuals without an autoimmune (AI) disease is not known. We tested the hypothesis that the presence of a high ANA titer in non‐AI conditions is associated with disease.
Matthew Chung, John P. Shelley, Gul Karakoc, John Still, Xiaodi Ruan, Jonathan Mosley, C. Michael Stein, Vivian K. Kawai   +7 more
wiley   +1 more source