Results 101 to 110 of about 849,024 (375)

Gelsolin's Protective Role in MASH through F‐Actin Regulation and P53 Degradation

Advanced Science, EarlyView.
Gelsolin (GSN) maintains liver metabolic homeostasis by promoting MDM2‐mediated P53 degradation and inhibiting F‐actin/Yes‐associated protein (YAP) overactivation. Loss of GSN impairs P53 degradation, increases lipid deposition, and enhances YAP‐driven fibrosis and inflammation in metabolic‐associated steatohepatitis.
Yiwei Lu, Tong Ji, Zhichao Ye, Jianing Yan, Chao Wang, Jiachen Chen, Ziyang Jin, Yongji Zhu, Xiujun Cai, Yifan Wang   +9 more
wiley   +1 more source

Mathematical analysis of an extended cellular model of the Hepatitis C Virus infection with non-cytolytic process [PDF]

arXiv, 2019
The aims of this work is to analyse of the global stability of the extended model of hepatitis C virus(HCV) infection with cellular proliferation, spontaneous cure and hepatocyte homeostasis. We first give general information about hepatitis C. Secondly, We prove the existence of local, maximal and global solutions of the model and establish some ...
arxiv  

Sofosbuvir and ribavirin before liver re-transplantation for graft failure due to recurrent hepatitis C: a case report. [PDF]

, 2015
BACKGROUND: Recurrent hepatitis C virus infection after liver transplantation is associated with reduced graft and patient survival. Re-transplantation for graft failure due to recurrent hepatitis C is controversial and not performed in all centers. CASE
Chtioui, H., Decosterd, L.A., Giostra, E., Majno, P.E., Moradpour, D., Pascual, M., Vionnet, J.   +6 more
core   +3 more sources

Recent Advances in mRNA Delivery Systems for Cancer Therapy

Advanced Science, EarlyView.
This review systematically investigates the applications of mRNA therapy in cancer treatment, with particular emphasis on nonviral delivery systems, targeting strategies, stimulus‐responsive systems, and local delivery methods. Concluding with a meticulous evaluation, the review sheds light on the prevailing challenges while illuminating promising ...
Zheng Zhang, Ya‐Nan Fan, Si‐Qi Jiang, Ya‐Jing Ma, Yao‐Ru Yu, Yu‐Xin Qing, Qian‐Ru Li, Yi‐Lin Liu, Song Shen, Jun Wang   +9 more
wiley   +1 more source

A Markov model for the spread of Hepatitis C [PDF]

arXiv, 2008
We propose a Markov model for the spread of Hepatitis C virus (HCV) among drug users who use injections. We then proceed to an asymptotic analysis (large initial population) and show that the Markov process is close to the solution of a non linear autonomous differential system.
arxiv  

Diverse CD81 proteins support hepatitis C virus infection. [PDF]

, 2006
Hepatitis C virus (HCV) entry is dependent on CD81. To investigate whether the CD81 sequence is a determinant of HCV host range, we expressed a panel of diverse CD81 proteins and tested their ability to interact with HCV.
Balfe, Peter, Farquhar, Michelle, Flint, Mike, Jones, Christopher T, McKeating, Jane A, Rice, Charles M, von Hahn, Thomas, Zhang, Jie   +7 more
core   +2 more sources

Facilitating crRNA Design by Integrating DNA Interaction Features of CRISPR‐Cas12a System

Advanced Science, EarlyView.
This study introduces a novel approach combining molecular dynamics simulations and neural network modeling to predict the Cas12a trans‐cleavage activity. By integrating sequence and molecular interaction features, prediction accuracy is enhanced, and identify key features affecting Cas12a trans‐cleavage activity.
Zhihao Yao, Wanglu Li, Kaiyu He, Hongmei Wang, Yan Xu, Qun Wu, Liu Wang, Yao Nie   +7 more
wiley   +1 more source

Mental health and quality of life in liver transplant and cirrhotic patients with various etiologies [PDF]

, 2012
In this study we aimed to: 1) examine whether there were differences in mental health and quality of life of liver transplant recipients according to etiology that led to transplantation (alcoholic cirrhosis, Hepatitis B/C Virus, hepatocellular ...
Bernardos Rodríguez, Ángel, Borda Mas, María de las Mercedes, Domínguez Cabello, Elisabeth, Fernández Jiménez, Eduardo, Martín Rodríguez, Agustín, Pérez San Gregorio, María de los Ángeles   +5 more
core   +1 more source

Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease

Advanced Science, EarlyView.
The first crystal structure of MPXV I7L protease, revealing its unique dimeric form is resolved. The structures and MD simulations uncovered a dynamic cap region that regulates substrate access to the active site. The structural basis of substrate recognition and the catalytic mechanism are elucidated, which led to the development of a FRET‐based assay
Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu   +12 more
wiley   +1 more source

Screening for Hepatitis C Among Community Health Center Patients by Ethnicity and Language Preference

AJPM Focus, 2023
Introduction: Hepatitis C virus is associated with high morbidity and mortality—chronic liver disease is a leading cause of death among Latinos in the U.S.
Brian L. Chan, MD, MPH, David Ezekiel-Herrera, MS, Steffani R. Bailey, PhD, Miguel Marino, PhD, Jennifer A. Lucas, PhD, MPH, Sophia Giebultowicz, MS, Erika Cottrell, PhD, MPP, Joe Carroll, MD, John Heintzman, MD, MPH   +8 more
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