Results 141 to 150 of about 912,975 (349)

Lipocalin‐2 activates hepatic stellate cells and promotes nonalcoholic steatohepatitis in high‐fat diet–fed Ob/Ob mice

Hepatology, EarlyView., 2022
Graphical summary of obesity‐induced NASH progression by LCN2 targeted to HSC activation. Abstract Background and Aims In obesity and type 2 diabetes mellitus, leptin promotes insulin resistance and contributes to the progression of NASH via activation of hepatic stellate cells (HSCs).
Kyung Eun Kim, Jaewoong Lee, Hyun Joo Shin, Eun Ae Jeong, Hye Min Jang, Yu Jeong Ahn, Hyeong Seok An, Jong Youl Lee, Meong Cheol Shin, Soo Kyoung Kim, Won Gi Yoo, Won Ho Kim, Gu Seob Roh   +12 more
wiley   +1 more source

Hepatitis C guidance: AASLD‐IDSA recommendations for testing, managing, and treating adults infected with hepatitis C virus

Hepatology, 2015
Aasld Idsa Hcv Guidance Panel
semanticscholar   +1 more source

Seroprevalence of Hepatitis C Virus among Health Care Workers

, 1970
MR Uddin, M Ashadul Islam, MZ Hossain, MN Sarker, ASM Salimullah, F Begum, DS Ahmed, AHM Towhidul Alam, PK Roy, ASMA Raihan   +9 more
openalex   +2 more sources

Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions [PDF]

, 1993
Ralf Bartenschlager, L Ahlborn-Laake, Jan Mous, Helmut Jacobsen   +3 more
openalex   +1 more source

Prognostic Impact of Hepatectomy Versus Radiofrequency Ablation for Non‐Small Hepatocellular Carcinoma (2–3 cm): A Case‐Matched Study

Annals of Gastroenterological Surgery, EarlyView.
This study aims to elucidate prognostic outcomes of hepatectomy versus RFA for primary 2–3 cm HCC. Hepatectomy may offer superior prognostic benefits, especially in those with elevated AFP levels. The local recurrence rate in hepatectomy is significantly lower than RFA.
Yuki Kitano, Hiromitsu Hayashi, Takumi Tanizaki, Yoshiyuki Tagayasu, Takashi Matsumoto, Rumi Itoyama, Shigeki Nakagawa, Hirohisa Okabe, Masaaki Iwatsuki   +8 more
wiley   +1 more source

Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma

Hepatology, EarlyView., 2022
Steatotic HCC can be diagnosed by MRI and forms a pro‐tumor immune microenvironment with high expression of PD‐L1, M2 polarization of macrophages and activation of CAFs, which may be a good target for combined immunotherapy. Abstract Background and Aims Immunotherapy has become the standard‐of‐care treatment for hepatocellular carcinoma (HCC), but its ...
Hiroki Murai, Takahiro Kodama, Kazuki Maesaka, Shoichiro Tange, Daisuke Motooka, Yutaka Suzuki, Yasuyuki Shigematsu, Kentaro Inamura, Yoshihiro Mise, Akio Saiura, Yoshihiro Ono, Yu Takahashi, Yota Kawasaki, Satoshi Iino, Shogo Kobayashi, Masashi Idogawa, Takashi Tokino, Tomomi Hashidate‐Yoshida, Hideo Shindou, Masanori Miyazaki, Yasuharu Imai, Satoshi Tanaka, Eiji Mita, Kazuyoshi Ohkawa, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Hidetoshi Eguchi, Eiichi Morii, Tetsuo Takehara   +29 more
wiley   +1 more source

Complete Replication of Hepatitis C Virus in Cell Culture

Science, 2005
B. Lindenbach, M. Evans, A. Syder, B. Wölk, T. Tellinghuisen, Christopher C. Liu, T. Maruyama, R. Hynes, D. Burton, J. McKeating, C. Rice   +10 more
semanticscholar   +1 more source

Antigenic regions within the hepatitis C virus envelope 1 and non-structural proteins: identification of an IgG3-restricted recognition site within the envelope 1 protein [PDF]

, 1993
Matti Sällberg, Ulla Rudén, Britta Wahrén, Lars O. Magnius   +3 more
openalex   +1 more source

Surgery for Older Cancer Patients: Cross‐Organ Review and Good Practice Statement by the Japanese Geriatric Oncology Guideline Committee

Annals of Gastroenterological Surgery, EarlyView.
We conducted a cross‐organ review of surgical outcomes in older cancer patients based on literature cited in Japanese clinical guidelines. This study summarizes postoperative complication rates and survival outcomes across five major cancer types. The findings aim to support the development of geriatric oncology surgical guidelines tailored to Japan's ...
Chie Tanaka, Takashi Ofuchi, Kiichiro Ninomiya, Daisuke Inoue, Ken Sugimoto, Keiko Murofushi, Toru Okuyama, Shigeaki Watanuki, Chiyo Imamura, Daisuke Sakai, Naomi Sakurai, Kiyotaka Watanabe, Kazuo Tamura, Toshiaki Saeki, Hiroshi Ishiguro   +14 more
wiley   +1 more source

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source