Results 81 to 90 of about 1,093,936 (286)

Helicobacter pylori‐Induced Persistent IGF2BP1 Activation Promotes Ferroptosis Resistance in Gastric Tumorigenesis

Advanced Science, EarlyView.
Helicobacter pylori infection induces sustained upregulation of the RNA‐binding protein IGF2BP1 in gastric epithelial cells, establishing a persistent epitranscriptomic program. IGF2BP1 stabilizes SLC7A11 mRNA in an m6A‐dependent manner to suppress ferroptosis and promote epithelial survival under oxidative stress. Pharmacological inhibition of IGF2BP1
Jing Ning, Xin Guan, Xinyu Hao, Jing Zhang, Deyao Li, Ying Xiong, Wenlin Zhang, Xiurui Han, Yanfei Lang, Meiling Zhou, Mengjie Yang, Zhi Huang, Tinghui Qu, Ming Zu, Qiao Meng, Weiwei Fu, Fengmin Lu, Jing Zhang, Xiangmei Chen, Tong Liu, Shigang Ding   +20 more
wiley   +1 more source

A novel nomogram for the early identification of coinfections in elderly patients with coronavirus disease 2019

Virology Journal
Objectives This study aimed to establish a novel and practical nomogram for use upon hospital admission to identify coinfections among elderly patients with coronavirus disease 2019 (COVID-19) to provide timely intervention, limit antimicrobial agent ...
Ju Zou, Xiaoxu Wang, Jie Li, Min Liu, Xiaoting Zhao, Ling Wang, Xuyuan Kuang, Yan Huang, Jun Quan, Ruochan Chen   +9 more
doaj   +1 more source

Biomarkers in Detection of Hepatitis C Virus Infection

Pathogens
The hepatitis C virus (HCV) infection affects 58 million people worldwide. In the United States, the incidence rate of acute hepatitis C has doubled since 2014; during 2021, this increased to 5% from 2020.
Jungreem Woo, Youkyung Choi
doaj   +1 more source

Raman Analysis of RNA Nucleotide Strands From SARS‐CoV‐2 Variants and Subvariants: A Step Forward in the Definition of “Raman Genome”

Advanced Science, EarlyView.
Main Raman signals in RNA, related to helical backbone, ribofuranose ring, and nitrogenous bases, are affected by secondary structures that cause hyperchromic effects and significantly alter the Raman intensity. ABSTRACT Raman spectra of RNA nucleotide strands extracted from 20 SARS‐CoV‐2 strains, including the original Japanese isolate, Alpha, Beta ...
Giuseppe Pezzotti, Yoshiki Yasukochi, Gianluca Angiola, Takaharu Ueno, Saki Ikegami, Rintaro Okawa, Tetsuya Adachi, Wenliang Zhu, Osam Mazda, Alfio Grillo, Koichiro Higasa, Kazu Okuma   +11 more
wiley   +1 more source

Blood‐borne viruses and their survival in the environment: is public concern about community needlestick exposures justified?

Australian and New Zealand Journal of Public Health, 2003
Background: More than 30 million needle syringes are distributed per year in Australia as a component of harm‐reduction strategies for injecting drug users (IDU).
Sandra C. Thompson, Clem R. Boughton, Gregory J. Dore   +2 more
doaj   +1 more source

Putting viral hepatitis on the map [PDF]

The DVH-funded FOA PS08-801 was intended to integrate primary and secondary viral hepatitis prevention services, education and counseling into health care settings and programs that serve adults at risk for viral hepatitis.

core  

RBM25 Drives Hepatocellular Carcinoma Progression by Stabilizing YAP Through Regulating Oncogenic Splicing‐switch of MYPT1

Advanced Science, EarlyView.
This study establishes that the RBM25‐PRPF40A interaction modulates MYPT1 splicing, promoting the production of the oncogenic long isoform. This isoform stabilizes YAP by suppressing its phosphorylation and subsequent proteasomal degradation, ultimately accelerating tumor growth.
Wenjing Zhang, Lili Zhi, Tian Huang, Lingya Feng, Chaoqun Chen, Huanhuan Wei, Xiaolong Liu, Lei Chen, Jinrui Zhang, Ge Zhang, Baofeng Zhao, Rong Liu, Dan Chen, Yangfan Qi, Yang Wang   +14 more
wiley   +1 more source

Viral hepatitis surveillance United States, 2017 [PDF]

Each week, health departments report cases of hepatitis A, hepatitis B, and hepatitis C to the Centers for Disease Control and Prevention (CDC) through the National Notifiable Diseases Surveillance System (NNDSS).

core  

A Hepatocyte‐to‐Stellate Cell Axis Couples Alternate‐Day Fasting to Liver Fibrosis Resolution via ATG7 S‐Nitrosylation

Advanced Science, EarlyView.
Alternate‐day fasting suppresses mitochondrial complex II assembly via SDHAF4 to upregulate hepatocyte eNOS. The resulting nitric oxide S‐nitrosylates ATG7 at C184 in hepatic stellate cells, restraining autophagic flux and preventing their profibrotic activation.
Xueqiang Wang, Mengqi Zeng, Cunxiao Sun, Yuhan Gou, Zhaode Feng, Weiqiang Lv, Chaoying Yan, Hansen Wu, Pengfei Zhang, Jie Xu, Ke Cao, Hao Li, Mingge Ding, Zhongbo Liu, Xing Zhang, Jiankang Liu, Xuan Zou, Zhihui Feng   +17 more
wiley   +1 more source

Decline in reported AIDS cases in Brazil after implementation of the test and treat initiative

BMC Infectious Diseases, 2019
Background To evaluate the trends in AIDS detection and the AIDS-attributed death rate in Brazil between 2007 and 2015 and to determine the population characteristics associated with AIDS detection.
Gerson Fernando Mendes Pereira, Meritxell Sabidó, Alessandro Caruso, Adele Schwartz Benzaken   +3 more
doaj   +1 more source