Results 41 to 50 of about 21,170 (204)

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Functional screening identifies kinesin spindle protein inhibitor filanesib as a potential treatment option for hepatoblastoma

npj Precision Oncology
Hepatoblastoma is a rare pediatric liver malignancy usually treated with surgery and chemotherapy. To explore new treatment options for hepatoblastoma, drug screening was performed using six cell models established from aggressive hepatoblastoma tumors ...
Ruth Nousiainen, Katja Eloranta, Jani Saarela, Antti Hassinen, Tamara J. Luck, Stefano Cairo, Emilie Indersie, Swapnil Potdar, Michaela J. Feodoroff, Jouko Lohi, Lassi Paavolainen, David B. Wilson, Vilja Pietiäinen, Markku Heikinheimo, Marjut Pihlajoki   +14 more
doaj   +1 more source

Characterization of Pulmonary Metastases in Children With Hepatoblastoma Treated on Children\u27s Oncology Group Protocol AHEP0731 (The Treatment of Children With All Stages of Hepatoblastoma): A Report From the Children\u27s Oncology Group. [PDF]

, 2017
Purpose To determine whether the pattern of lung nodules in children with metastatic hepatoblastoma (HB) correlates with outcome. Methods Thirty-two patients with metastatic HB were enrolled on Children\u27s Oncology Group Protocol AHEP0731 and treated ...
Dunn, Stephen P., Finegold, Milton J., Furman, Wayne L., Gao, Yun, Katzenstein, Howard M., Krailo, Mark D., Langham, Max R., Malogolowkin, Marcio, McCarville, M. Beth, McGahren, Eugene D., Meyers, Rebecka L., O\u27Neill, Allison F., Ranganathan, Sarangarajan, Rodriguez-Galindo, Carlos, Tiao, Greg M., Towbin, Alexander J., Weldon, Christopher B., Xia, Caihong   +17 more
core   +1 more source

The SPLIT Research Agenda 2013 [PDF]

, 2013
This review focuses on active clinical research in pediatric liver transplantation with special emphasis on areas that could benefit from studies utilizing the SPLIT infrastructure and data repository.
Christopher D. Anderson, Emily M. Fredericks, Estella M. Alonso, Greg Tiao, Katryn N. Furuya, Nitika A. Gupta, null null, Ravinder Anand, Shikha Sundaram, Stacee M. Lerret, Udeme D. Ekong, Vicky L. Ng   +11 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Abnormal prothrombin (DES-y-Carboxy Prothrombin) in hepatocellular carcinoma [PDF]

, 1991
Des-γ-carboxy prothrombin (DCP), a protein induced by vitamin K absence or antagonist-II (PIVKA-II) was measured by an enzyme immunoassay (E-1023) using anti-DCP monoclonal antibody in 92 patients with various hepatobiliary diseases. Thirty-six of the 38
Carr, B, Iwaki, Y, Iwatsuki, S, Nakao, A, Starzl, E, Virji, A   +5 more
core  

Paternal obesity is associated with IGF2 hypomethylation in newborns: results from a Newborn Epigenetics Study (NEST) cohort [PDF]

, 2013
Data from epidemiological and animal model studies suggest that nutrition during pregnancy may affect the health status of subsequent generations. These transgenerational effects are now being explained by disruptions at the level of the epigenetic ...
A Kerjean, A Murrell, A Soubry, AD Stein, Adelheid Soubry, Amy Murtha, AP Feinberg, Autumn Bernal, BE Levin, BR Carone, BT Heijmans, C Gemma, C Gicquel, C Hoyo, C Hoyo, Cathrine Hoyo, CC Boissonnas, DC Dolinoy, DC Dolinoy, DJ Barker, Frances Wang, G Kaati, GA Dunn, GP Ravelli, H Boerschmann, H Cui, H Cui, H Cui, J Baker, J Frystyk, JA McKay, Joanne Kurtzberg, Joellen M Schildkraut, JS Dyer, KJ Stothard, LM McCowan, M Braunschweig, M Cruz-Correa, M Ollikainen, ME Pembrey, ME Pembrey, MJ Steenman, MJ Sullivan, Q Wu, R Barres, R Figueroa-Colon, R Loomba, RA Waterland, RA Waterland, RA Waterland, Randy L Jirtle, RC Painter, RC Painter, RL Jirtle, RP Steegers-Theunissen, S Honda, S Katari, S Pathak, SA Tanumihardjo, SD McDonald, SF Ng, SK Murphy, SK Murphy, SK Murphy, SS Du Plessis, Susan K Murphy, W Chao, Z Huang, Zhiqing Huang   +68 more
core   +3 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Paraneoplastic Recurrent Hypoglycaemic Seizures: An Initial Presentation of Hepatoblastoma in an Adolescent Male—A Rare Entity

Case Reports in Pediatrics, 2014
Hepatoblastoma (HB) is a rare malignant tumour of the liver and usually occurs in the first three years of life. Hepatoblastoma in adolescents and young adults is extremely rare; nevertheless the prognosis is much worse than in childhood, because these ...
Irappa Madabhavi, Apurva Patel, Mukesh Choudhary, Suhas Aagre, Swaroop Revannasiddaiah, Gaurang Modi, Asha Anand, Harsha Panchal, Sonia Parikh, Shreeniwas Raut   +9 more
doaj   +1 more source

Multifocal hepatoblastoma in a 6-month-old girl with trisomy 18: a case report

Journal of Medical Case Reports, 2009
Introduction Edward's syndrome (trisomy 18) is a rare entity with a reported incidence of 1/3000 to 1/7000 births. Less than 10% of patients survive beyond the first year of life, which may influence the fact that malignant tumors are rarely reported in ...
Kitanovski Lidija, Ovcak Zdenka, Jazbec Janez   +2 more
doaj   +1 more source