Results 121 to 130 of about 21,046 (260)

Piperazine and Morpholine Protoporphyrin IX Derivatives Intensify Biomolecules Oxidation and Phototoxicity in Triple‐Negative Breast Cancer

ChemMedChem, Volume 21, Issue 17, 14 September 2026.
Protoporphyrin IX derivatives bearing piperazine or morpholine substituents exhibit enhanced cellular retention and photodynamic activity in triple‐negative breast cancer cells. Structural modification promotes oxidative stress, alters mitochondrial membrane potential, and increases caspase‐3 activity, providing new structure–activity relationship ...
Maynne Duarte Suriani Franco, Thibault Joseph William Jacques Dit Lapierre, Tarcisio Paiva Mendonça, Luiz Felipe Fernandes Peixoto, Renata Roland Teixeira, Joyce Ferreira Da Costa Guerra, Kelly Aparecida Geraldo Yoneyama Tudini, Daniele Lisboa Ribeiro, Foued Salmen Espindola, Allisson Benetti Justino, Celso de Oliveira Rezende Júnior, Tayana Mazin Tsubone   +11 more
wiley   +1 more source

Anticancer Peptide fromChinese Toad (Bufo Bufo Gargarizans) Skin Enhanced Sensitivity to 5-Fu in Hepatocarcinoma cells (HepG2)

Cancer Biology & Medicine, 2011
OBJECTIVE To investigate the antiproliferative and apoptogenic activities of peptide extracted from the Chinese toad (Bufo bufogargarizans) skin (TSP) and its effects on hepatocarcinoma cell line.METHODS MTT assaywas used to detect the effects of TSP ...
Chuang-xin LU, Wen-yu WANG, Ning MA, Yao CUI, Xiao-yan LI, Yun ZHOU   +5 more
doaj  

Tromboembolismo tumoral como causa directa de muerte

Revista Habanera de Ciencias Médicas, 2020
Introducción: el embolismo tumoral pulmonar es la presencia de acúmulos de células tumorales en las arterias pulmonares arteriolas y capilares pulmonares.
Antonio Belaunde Clausell, Alicia Morales Días, Yordan Rodríguez Hernández   +2 more
doaj  

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, Volume 20, Issue 9, Page 2356-2381, September 2026.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

RNA‐Binding Protein RBM25 Targets the mRNA Stability of GTPase Rab22a to Restrict Viral Entry and Infection

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This study identifies RNA‐binding protein RBM25 as a broad‐spectrum antiviral factor acting independently of type I interferon. It blocks viral entry by suppressing GTPase Rab22a via the RC3H1‐mediated destabilization of Rab22a mRNA. Viral downregulation of RBM25 enhances GTPase Rab22a expression and viral entry, revealing an unreported post ...
Yingying Ding, Huiying Chen, Yuyu Jiang, Chunyan Zhao, Jie Bai, Yan Xiang, Zeting Wang, Xixi Wang, Bing Rui, Wanda Tang, Yue Ding, Zhenzhen Zhan, Yunkai Zhang, Xingguang Liu   +13 more
wiley   +1 more source

A clinical perspective of the link between metabolic syndrome and hepatocellular carcinoma

Journal of Hepatocellular Carcinoma, 2015
François Cauchy, Jacques BelghitiHPB and Liver Transplantation Unit, Hôpital Beaujon, Assistance Publique-Hôpitaux de Paris, Clichy, FranceAbstract: Metabolic syndrome (MS), which is defined as a constellation of clinico-biological ...
Cauchy F, Belghiti J
doaj  

FK866-induced NAMPT inhibition activates AMPK and downregulates mTOR signaling in hepatocarcinoma cells

, 2015
Background: Nicotinamide phosphoribosyltransferase (NAMPT) is the key enzyme of the NAD salvage pathway starting from nicotinamide. Cancer cells have an increased demand for NAD due to their high proliferation and DNA repair rate.
Penke, Melanie, Garten, Antje, Gebhardt, Rolf, Gorski, Theresa, Weiss, Thomas S., Schuster, Susanne, Kiess, Wieland   +6 more
core   +1 more source

RBM12 Maintains Glioma Stem Cells by Activating Amino Acid‐Dependent mTORC1 Signaling via SLC7A5 mRNA Stabilization

Advanced Science, Volume 13, Issue 52, 18 September 2026.
This study shows that in glioma stem cells (GSCs), RBM12 recruits ALKBH5 to remove m6A from SLC7A5 transcripts, thereby enhancing mRNA stability, which elevates large neutral amino acid (LNAA) levels and activates mTORC1, promoting GSC proliferation, self‐renewal, and tumor growth.
Hong Lei, Wenlong Luo, Shu Zhou, Lihao Wan, Peng Ling, Zhihua Huang, Zhihua Qian, Chenfei Lu, Mengyue Guo, Zhen Xue, Jun Qin, Ningwei Zhao, Jianghong Man, Wenchao Zhou, Zhiqiang Dong, Shutong Xu, Zhipeng Zhou, Xiuxing Wang, Weiwei Tao   +18 more
wiley   +1 more source

Hepatocarcinoma. Hemoperitoneum

, 1974
Presentamos un caso de carcinoma primitivo de higado, en el cual destacamos: la forma de presentación clínica, la aparición de un hígado no cirrótico, la presencia de un hemoperitoneo, y la aparición multicéntrica del tumor.
Chifflet, Juan, Cassinelli, Daniel, Toledo, Nancy   +2 more
openaire   +1 more source

MARBLE: An in vivo MRI marker of limbic‐predominant age‐related TDP‐43 encephalopathy neuropathologic change (LATE‐NC)

Alzheimer's &Dementia, Volume 22, Issue 9, September 2026.
Abstract INTRODUCTION Limbic‐predominant age‐related transactive response DNA binding protein 43 kDa encephalopathy neuropathologic change (LATE‐NC) is common in older adults, yet definitive diagnosis is only possible at autopsy. METHODS This work developed a fully automated in vivo marker of LATE‐NC named MARBLE (MARker of Brain LatE) by applying ...
Mahir Tazwar, Arnold M. Evia, Abdur R. Ridwan, Sue E. Leurgans, Maude Wagner, Alzheimer's Disease Neuroimaging Initiative, David A. Bennett, Julie A. Schneider, Konstantinos Arfanakis   +8 more
wiley   +1 more source