Results 41 to 50 of about 25,003 (247)

Bidirectional interaction of lncRNA AFAP1-AS1 and CRKL accelerates the proliferative and metastatic abilities of hepatocarcinoma cells

Journal of Advanced Research, 2020
Actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1), a long non-coding RNA transcribed from the antisense strand of protein coding gene AFAP1, has attracted attention in cancer research.
Sattar Abdul, Abbasi Majid, Jinxia Wang, Qinlong Liu, Ming-Zhong Sun, Shuqing Liu   +5 more
doaj   +1 more source

Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening

Frontiers in Pharmacology, 2020
Background: Cancer is the second leading cause of death globally. However, most of the new anti-cancer agents screened by traditional drug screening methods fail in the clinic because of lack of efficacy.
Wei Liao, Wanren Yang, Yue Zhang, Fanhong Zeng, Jiecheng Xu, Zhengming Yan, Ming-Zhi Pan, Xiaoping Xu, Shuqin Zhou, Min Zeng, Jun Weng, Xu Han, Shao Li, Yang Li, Kang-yan Liang, Qing Peng, Yi Gao   +16 more
semanticscholar   +1 more source

JNK activation and translocation to mitochondria mediates mitochondrial dysfunction and cell death induced by VDAC opening and sorafenib in hepatocarcinoma cells.

Biochemical Pharmacology, 2019
Opening of voltage dependent anion channels (VDAC) by the erastin-like compound X1 and the multikinase inhibitor sorafenib promotes oxidative stress and mitochondrial dysfunction in hepatocarcinoma cells.
Kareem A. Heslop, A. Rovini, Elizabeth G. Hunt, Diana Fang, Morgan E. Morris, C. F. Christie, M. Gooz, David N. DeHart, Yujing Dang, J. Lemasters, E. Maldonado   +10 more
semanticscholar   +1 more source

Berberine, a natural alkaloid sensitizes human hepatocarcinoma to ionizing radiation by blocking autophagy and cell cycle arrest resulting in senescence

The Journal of pharmacy and pharmacology, 2020
To study the radiosensitizing potential of Berberine and the underlying mechanism in human hepatocarcinoma (HepG2) cells.
Gautham Ramesh, Shubhankar Das, Satish Rao Bola Sadashiva   +2 more
semanticscholar   +1 more source

Antitumor Effects of Quercetin in Hepatocarcinoma In Vitro and In Vivo Models: A Systematic Review

Nutrients, 2019
Quercetin is a flavonoid present in fruits, vegetables and plants with antioxidant, anti-inflammatory and anticancer properties. Its beneficial activities have been demonstrated in different human pathologies, including hepatoprotective effects against ...
Paula Fernández-Palanca, F. Fondevila, C. Méndez-Blanco, M. Tuñón, J. González‐Gallego, J. Mauriz   +5 more
semanticscholar   +1 more source

Curcumin Suppresses Hepatic Stellate Cell-Induced Hepatocarcinoma Angiogenesis and Invasion through Downregulating CTGF

Oxidative Medicine and Cellular Longevity, 2019
Microenvironment plays a vital role in tumor progression; we focused on elucidating the role of hepatic stellate cells (HSCs) in hepatocarcinoma (HCC) aggressiveness and investigated the potential protective effect of curcumin on HSC-driven ...
S. Shao, Wanxing Duan, Qinhong Xu, Xuqi Li, Liang Han, Wei Li, Dong Zhang, Z. Wang, Jianjun Lei   +8 more
semanticscholar   +1 more source

RETRACTED: Wogonin Suppresses the Activity of Matrix Metalloproteinase-9 and Inhibits Migration and Invasion in Human Hepatocellular Carcinoma

Molecules, 2018
As one of the major active ingredients in Radix Scutellariae, wogonin has been shown to be associated with various pharmacological activities on cancer cell growth, apoptosis, and cell invasion and migration. Here, we demonstrated that wogonin may harbor
Ming Hong, Honghui Cheng, Lei Song, Wencai Wang, Qi Wang, Donggang Xu, Weiwei Xing   +6 more
doaj   +1 more source

Altered Gut Microbiota Composition and Its Potential Association in Patients with Advanced Hepatocellular Carcinoma

Current Oncology, 2023
Hepatocellular carcinoma (HCC) is the second-most-common cause of cancer death. In recent years, studies have suggested that intestinal microbiota dysregulation is closely related to HCC and can affect the therapeutic efficacy of immune checkpoint ...
Ran Huo, Yanlin Chen, Jie Li, Quanguo Xu, Junying Guo, Haiyan Xu, Yiqing You, Chaoqiang Zheng, Yan Chen   +8 more
doaj   +1 more source

MicroRNA-375 represses tumor angiogenesis and reverses resistance to sorafenib in hepatocarcinoma

Cancer Gene Therapy, 2020
Sorafenib was originally identified as an inhibitor of multiple oncogenic kinases and remains the first-line systemic therapy for advanced hepatocellular carcinoma (HCC).
Dong Li, Tao Wang, F. Sun, Jian Feng, J. Peng, Hua Li, Chao Wang, Dandan Wang, Yu Liu, Yusi Bai, M. Shi, Tao Zhang   +11 more
semanticscholar   +1 more source

Mini-review. Liver transplantation for hepatocellular carcinoma

Revista Médica del Hospital General de México, 2018
Liver transplantation is the gold standard treatment for end stage liver disease, including patients with cirrhosis and hepatocarcinoma falling within Milan criteria.
V. Visag-Castillo
doaj   +1 more source