Results 41 to 50 of about 21,046 (260)

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Countrywide Survey of Plants Used for Liver Disease Management by Traditional Healers in Burkina Faso

Frontiers in Pharmacology, 2020
Liver disease is highly prevalent in Africa, especially in the western African country Burkina Faso, due to the presence of multiple biological and chemical aggressors of the liver. Furthermore, diagnosis and appropriate care for liver disease are uneven
André Tibiri, Sébastien Boria, Tata Kadiatou Traoré, Noufou Ouédraogo, Aude Nikièma, Souleymane Ganaba, Jean-Marie Compaoré, Issiaka Ouédraogo, Innocent Pierre Guissou, Innocent Pierre Guissou, Maëlle Carraz   +10 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Hepatocarcinoma pediculado [PDF]

, 2017
Se presenta el caso de una paciente fallecida con diagnóstico de hepatocarcinoma pediculado, el cual se presentó clinicamente como masa palpable en epigastrio y asociado a un higado ...
Martínez Navarro, Javier
core  

Bioactivity-guided isolation of antioxidant and anti-hepatocarcinoma constituents from Veronica ciliata

, 2016
Background: Veronica ciliata Fisch., widely distributed in western China, has been traditionally used in Tibetan Medicine as a treatment for hepatitis, cholecystitis, rheumatism, and urticaria. However, V. ciliata Fisch.
Lu, QX, Tan, SC, Yin, L, Ding, LS, Guo, YR, Tang, L, Chen, F, Tang, L (reprint author), Sichuan Univ, Coll Life Sci, Key Lab Bioresources & Ecoenvironm, Minist Educ, 24 South Sect 1,Yihuan Rd, Chengdu, Peoples R China.   +7 more
core   +1 more source

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Hipoglicemia asociada a hepatocarcinoma [PDF]

, 2019
Se reporta el caso de un varón 27 años que desarrolló hipoglicemia grave como manifestación de un hepatocarcinoma por infección de hepatitis ...
Sánchez Hurtado, Luis, Delgado Cruz, Diana Amalís, Basurco Medina, Vania   +2 more
core  

Vascularized Liver‐on‐a‐Microsphere Reveals Alanine‐Glucose Metabolism‐Driven Regulation of Liver Function and Injury

Advanced Science, EarlyView.
A vascularized liver‐on‐a‐microsphere system is developed to recreate lobule‐like cellular organization and endothelial barrier function within compartmentalized hydrogel particles. The platform enhances hepatic performance and reveals alanine‐glucose cycle activation linked to improved detoxification capacity, offering a high‐throughput microscale ...
Jingyang Li, Zengnan Wu, Yingrui Zhang, Shulang Chen, Yongning Lin, Shiyu Chen, Tong Xu, Xianli Meng, Yi Zhang, Jin‐Ming Lin   +9 more
wiley   +1 more source

Sensitization effect of kaempferol from persimmon leaves on HepG2 hepatoma cells with ABT-199 resistance and its molecular mechanisms

Frontiers in Pharmacology, 2022
ABT-199 (venetoclax) is the first-in-class selective B-cell lymphoma 2 (BCL2) inhibitor, which is known to be ineffective towards liver cancer cells. Here, we investigated the efficacy and the underlying molecular processes of the sensitization effect of
Li Chen, Li Chen, Xudong Jiang, Si Gao, Xueping Liu, Ying Gao, Audrey Siew Foong Kow, Chau Ling Tham, Ming Tatt Lee   +8 more
doaj   +1 more source

Decoding Viral Transmission Dynamics in Structured Populations Using a Microfluidic Herd‐Immunity‐on‐a‐Chip Platform

Advanced Science, EarlyView.
A microfluidic Herd‐Immunity‐on‐a‐Chip experimentally recreates structured contact networks to quantify viral transmission dynamics. By controlling susceptible, infected, and non‐susceptible populations, the platform reveals how contact topology governs the reproduction number, outbreak propagation, herd‐immunity–like behavior, and intervention ...
Jiande Zhang, Narina Jung, Min‐Hyeok Kim, Wanyoung Lim, Zhenzhong Chen, Byung Mook Weon, Sungsu Park   +6 more
wiley   +1 more source