Results 51 to 60 of about 25,003 (247)

β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations

Advanced Biology, Volume 9, Issue 3, March 2025.
Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio, B. Spedicato, G. Corallo, A. Inguscio, M. Greco, D. Musarò, D. Vergara, A. F. Muro, G. De Sabbata, L. R. Soria, N. Brunetti Pierri, M. Maffia   +11 more
wiley   +1 more source

Countrywide Survey of Plants Used for Liver Disease Management by Traditional Healers in Burkina Faso

Frontiers in Pharmacology, 2020
Liver disease is highly prevalent in Africa, especially in the western African country Burkina Faso, due to the presence of multiple biological and chemical aggressors of the liver. Furthermore, diagnosis and appropriate care for liver disease are uneven
André Tibiri, Sébastien Boria, Tata Kadiatou Traoré, Noufou Ouédraogo, Aude Nikièma, Souleymane Ganaba, Jean-Marie Compaoré, Issiaka Ouédraogo, Innocent Pierre Guissou, Innocent Pierre Guissou, Maëlle Carraz   +10 more
doaj   +1 more source

Synthetic Nanobiology Actuated Lipometabolic Cell Factory for Autologous Tumor Immunotherapy

Advanced Functional Materials, EarlyView.
FA plays a crucial role in the interaction between tumor cells and the tumor microenvironment, especially for the immune response. A biocatalytic immunoenhancement strategy is developed to boost antitumor immunity by FA metabolic orientation to ceramide. Through the design of this delicate catalytic immunoenhancement strategy, the synthetic nanobiology
Shoujie Zhao, Yejing Zhu, Hengchao Yu, Jun Zhu, Bo Wang, Yu Qiao, Zhimin Tian, Junlong Zhao, Lei Liu   +8 more
wiley   +1 more source

Hydroxysteroid sulfotransferase SULT2B1b promotes hepatocellular carcinoma cells proliferation in vitro and in vivo. [PDF]

PLoS ONE, 2013
Hydroxysteroid sulfotransferase 2B1b (SULT2B1b) is highly selective for the addition of sulfate groups to 3β-hydroxysteroids. Although previous reports have suggested that SULT2B1b is correlated with cell proliferation of hepatocytes, the relationship ...
Xiaoming Yang, Yali Xu, Fenghua Guo, Yanxia Ning, Xiuling Zhi, Lianhua Yin, Xiaobo Li   +6 more
doaj   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Hepatocarcinoma: estado actual

Galicia Clínica, 2014
El carcinoma hepatocelular (CHC) es la neoplasia primaria hepática más frecuente. Constituye el sexto tumor más habitual en el mundo, con más de 500.000 casos diagnosticados cada año y es la tercera causa más común de muerte por cáncer.Esta enfermedad afecta de manera casi exclusiva a pacientes con hepato-patía crónica que han desarrollado cirrosis ...
Delgado Blanco, Manuel, Pin Vieito, noel, Guerrero Montañés, Alberto   +2 more
openaire   +5 more sources

Resultados do transplante hepático em portadores de hepatocarcinoma [PDF]

Arquivos de Gastroenterologia, 2001
Racional - O hepatocarcinoma é uma das doenças malignas mais comuns em todo o mundo. O transplante hepático é boa opção terapêutica para os pacientes com hepatocarcinoma em fase inicial, alcançando índices de sobrevida semelhantes aos encontrados nos ...
Mônica Beatriz PAROLIN, Júlio Cézar Uili COELHO, Jorge E. Fouto MATIAS, Vanessa PUCCINELLI, Rossano JARABIZA, Sérgio O. IOSHII   +5 more
doaj   +1 more source

Sorafenib Chemosensitization by Caryophyllane Sesquiterpenes in Liver, Biliary, and Pancreatic Cancer Cells: The Role of STAT3/ABC Transporter Axis

Pharmaceutics, 2022
A combination of anticancer drugs and chemosensitizing agents has been approached as a promising strategy to potentiate chemotherapy and reduce toxicity in aggressive and chemoresistant cancers, like hepatocellular carcinoma (HCC), cholangiocarcinoma ...
Silvia Di Giacomo, Marco Gullì, Roberta Facchinetti, Marco Minacori, Romina Mancinelli, Ester Percaccio, Caterina Scuderi, Margherita Eufemi, Antonella Di Sotto   +8 more
doaj   +1 more source

Metabolic syndrome, non-alcoholic fatty liver disease and hepatocarcinoma.

Revista Espanola de Enfermedades Digestivas, 2020
The term "metabolic syndrome" refers to a group of alterations comprising central obesity reduced high-density lipoprotein cholesterol concentrations, elevated triglyceride concentrations, arterial hypertension, and hyperglycemia.
Mario Serradilla Martín, J. R. Oliver Guillén, A. Palomares Cano, J. M. Ramia Ángel   +3 more
semanticscholar   +1 more source

An Artificial Antibody‐Based Toolbox Accelerates Validation of Hidden Microproteins Encoded by the Dark Genome

Advanced Science, EarlyView.
Microproteins are hidden treasures encoded by the “dark proteome” but remain largely underexplored due to the lack of highly efficient tools. We developed a molecularly imprinted polymers (MIPs)‐based toolbox (CLAIMID) to achieve accelerated and ultrasensitive microproteins validation at multiple biological scales (single living cells, cell populations,
Hui He, Anqi Zhang, Zhanchen Guo, Qi Li, Song Gao, Wenyan Guan, Ying Li, Jingran Chen, Sijia Sun, Jian He, Zhen Liu   +10 more
wiley   +1 more source