Results 61 to 70 of about 33,100 (246)

Lipid Droplet‐Localized Spindle Apparatus Coiled‐Coil Protein 1 Regulates Lipid Droplet Distribution

Advanced Science, EarlyView.
SPDL1‐L, a long isoform of SPDL1, is identified as a bona fide lipid droplet‐associated protein that acts as a dynein adaptor to drive perinuclear clustering of lipid droplets. By linking lipid droplets to the microtubule network, SPDL1‐L extends the function of SPDL1 beyond mitosis and contributes to lipid droplet organization and nuclear remodeling ...
Honggang Su, Huimin Pan, Yaqiang Liu, Wei Wang, Yang Jiao, Yumo Hang, Xiahe Huang, Yong E. Zhang, Yuhang Chen, Mei Ding, Xun Huang   +10 more
wiley   +1 more source

La exposición a la aflatoxina B1 en animales de laboratorio y su significado en la salud pública Exposure to aflatoxin B1 in experimental animals and its public health significance

Salud Pública de México, 2007
En México se ha detectado la presencia AFB1 en humanos: como mutación en el gene p53 en hepatocarcinomas de pacientes de Monterrey, Nuevo León, México, en 1996 y como aducto AFB1-lisina en suero de pacientes del Instituto Mexicano del Seguro Social de ...
Doralinda Guzmán de Peña
doaj  

Laparoscopic liver resection for hepatocellular carcinoma in cirrhotic patients. Feasibility of nonanatomic resection in difficult tumor locations

Journal of Minimal Access Surgery, 2011
Background: Surgical resection for hepatocellular carcinoma (HCC) in cirrhotic patients remains controversial because of high morbidity and recurrence rates.
Marco Casaccia, Enzo Andorno, Stefano Di Domenico, Ilaria Nardi, Giuliano Bottino, Maximiliano Gelli, Umberto Valente   +6 more
doaj   +1 more source

Pheophorbide Esters A and B Isolated from Acai Berries as Activators of Apoptosis [PDF]

, 2019
Undergraduate ...
Siff, Thomas
core   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Tamizaje por hepatocarcinoma y estrategia de seguimiento en portadores del virus de hepatitis B

Acta Médica Costarricense, 2008
La utilización del ultrasonido abdominal y la alfafetoproteína juntas se consideran las pruebas de tamizaje aceptadas como más útiles en él seguimiento de los portadores crónicos del virus B.
Javier Cabas-Sánchez
doaj  

Multicystic Hepatocarcinoma Mimicking Liver Abscess [PDF]

Case Reports in Surgery, 2013
The diagnosis of hepatocellular carcinoma (HCC) became easier in relation to the improved radiological examinations; however, the neoplasm may occur under atypical presentations mimicking other benign or malignant processes. Multicystic HCC mimicking a liver abscess associated with septic-type fever and leukocytosis is rare, has a poor prognosis, and ...
Evangelos Falidas, Angelos Pazidis, Georgios Anyfantakis, Konstantinos Vlachos, Christina Goudeli, Constantinos Villias   +5 more
openaire   +3 more sources

Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD‐L1 Expression and Acts as a Target to Enhance Anti‐PD‐1 Efficacy

Advanced Science, EarlyView.
A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu, Ling Tang, Zheng Kuang, Danyi Huang, Ting Li, Gaofei Yin, Yingyu Chen, Wei Guo, Wenling Han, Pingzhang Wang   +9 more
wiley   +1 more source

Sensitization effect of kaempferol from persimmon leaves on HepG2 hepatoma cells with ABT-199 resistance and its molecular mechanisms

Frontiers in Pharmacology, 2022
ABT-199 (venetoclax) is the first-in-class selective B-cell lymphoma 2 (BCL2) inhibitor, which is known to be ineffective towards liver cancer cells. Here, we investigated the efficacy and the underlying molecular processes of the sensitization effect of
Li Chen, Li Chen, Xudong Jiang, Si Gao, Xueping Liu, Ying Gao, Audrey Siew Foong Kow, Chau Ling Tham, Ming Tatt Lee   +8 more
doaj   +1 more source

Amphiregulin contributes to the transformed phenotype of human hepatocellular carcinoma cells [PDF]

, 2006
Hepatocellular carcinoma is a major cause of cancer-related deaths. Current treatments are not effective, and the identification of relevant pathways and novel therapeutic targets are much needed.
Avila, M.A. (Matías Antonio), Berasain, C. (Carmen), Castillo, J. (Josefa), Erroba, E. (Elena), Lee, D.C. (David C.), Perugorria, M.J. (María J.), Prieto, J. (Jesús), Santamaria, M. (Mónica)   +7 more
core