Results 71 to 80 of about 25,003 (247)

La exposición a la aflatoxina B1 en animales de laboratorio y su significado en la salud pública Exposure to aflatoxin B1 in experimental animals and its public health significance

Salud Pública de México, 2007
En México se ha detectado la presencia AFB1 en humanos: como mutación en el gene p53 en hepatocarcinomas de pacientes de Monterrey, Nuevo León, México, en 1996 y como aducto AFB1-lisina en suero de pacientes del Instituto Mexicano del Seguro Social de ...
Doralinda Guzmán de Peña
doaj  

Glutamine Deprivation Triggers Tribbles Homolog 3 Dependent G‐Quadruplex Resolution to Maintain DNA Repair and Tumor Survival

Advanced Science, EarlyView.
Glutamine deprivation triggers transient DNA damage yet activates adaptive repair in hepatocellular carcinoma cells. We identify TRIB3 as a stress‐induced nuclear scaffold that associates with DDX5 and G‐quadruplex DNA atBRCA1 andRAD51AP1 promoters. TRIB3 loss increases G4 accumulation, suppresses HR gene transcription, elevates γ‐H2A.X, and sensitizes
Qiang Ji, Xuedan Sun, Zhangran Sun, Mengfan Li, Xinyu Cheng, Shuai Tian, Rick F. Thorne, Jinming Li, Guangzhi Liu, Mian Wu, Xiaoying Liu   +10 more
wiley   +1 more source

Tamizaje por hepatocarcinoma y estrategia de seguimiento en portadores del virus de hepatitis B

Acta Médica Costarricense, 2008
La utilización del ultrasonido abdominal y la alfafetoproteína juntas se consideran las pruebas de tamizaje aceptadas como más útiles en él seguimiento de los portadores crónicos del virus B.
Javier Cabas-Sánchez
doaj  

Isorhamnetin induces ROS-dependent cycle arrest at G2/M phase and apoptosis in human hepatocarcinoma Hep3B cells.

General Physiology and Biophysics, 2019
Isorhamnetin is a 3'-O-methylated metabolite of quercetin that is found predominantly in a variety of medicinal plants. Although many previous studies have reported that this flavonol has diverse health-promoting effects, evidence for the underlying ...
Yung-Hyun Choi
semanticscholar   +1 more source

Nanomedicine Meets Immunotherapy: Advancing Adoptive Cell Therapy with Nanoparticles in the Treatment of Cancer with Sustainability Perspectives

Advanced Science, EarlyView.
This review surveys nanoparticle‐based strategies to enhance adoptive cell therapy, particularly CAR‐T cell approaches, in solid tumor treatment. It describes how nanoparticles can improve tumor immunogenicity and T‐cell infiltration while reducing toxicity, and how they enable in vivo CAR‐T cell generation.
Erica Frostegård, Tatiana Bobrova, Amalie Leinebø, Thibault Leray, Shayamita Ghosh, Lorena García‐Hevia, Chiara Puccinelli, Lorenzo Riccio, Jacopo Sorani, Davide Bonifazi, Julien Caumartin, Emmanuel Donnadieu, Florence Gazeau, Roland Hischier, Else Marit Inderberg, Mónica L. Fanarraga, Maria Loustau, Bernd Nowack, Sébastien Wälchli, Cécilia Ménard‐Moyon   +19 more
wiley   +1 more source

Human amniotic membrane conditioned medium inhibits proliferation and modulates related microRNAs expression in hepatocarcinoma cells

Scientific Reports, 2019
The placental stem cells have called the focus of attention for their therapeutic potential to treat different diseases, including cancer. There is plenty evidence about the antiproliferative, antiangiogenic and proapoptotic properties of the amniotic ...
R. Riedel, A. Pérez-Pérez, A. Carmona-Fernández, Mariana Jaime, Roberto Casale, J. Dueñas, P. Guadix, V. Sánchez-Margalet, C. Varone, Julieta L. Maymó   +9 more
semanticscholar   +1 more source

Optimization and Characterization of Aspirin‐ and Ibuprofen‐Loaded Lipid‐Based Nanoparticle Synthesis for Antibacterial Activity and Cytotoxic Effect

Asia-Pacific Journal of Chemical Engineering, EarlyView.
ABSTRACT Lipid‐based nanoparticles (LNPs) are favored for drug delivery because of their low toxicity, high biocompatibility, ability to self‐assemble into nanoparticles, and ability to enhance drug bioavailability, thereby improving drug release modulation and pharmacokinetics.
Gulizar Caliskan, Smyrna Ergonul, Zuhal Naz Cansu, Busra Kaplan   +3 more
wiley   +1 more source

Cucurbitacin B Inhibits Hepatocellular Carcinoma by Inducing Ferroptosis and Activating the cGAS-STING Pathway

Current Issues in Molecular Biology
The incidence of primary liver cancer is increasing annually, with extremely high mortality and suboptimal therapeutic outcomes. The inefficient presentation of tumor antigens and low infiltration of specific cytotoxic T lymphocytes (CTLs) result in ...
Huizhong Zhang, Aqian Chang, Xiaohan Xu, Hulinyue Peng, Ke Zhang, Jingwen Yang, Wenjing Li, Xinzhu Wang, Wenqi Wang, Xingbin Yin, Changhai Qu, Xiaoxv Dong, Jian Ni   +12 more
doaj   +1 more source

Thioredoxin Downregulation Enhances Sorafenib Effects in Hepatocarcinoma Cells

Antioxidants, 2019
Sorafenib is the first-line recommended therapy for patients with advanced hepatocarcinoma (HCC) in de-differentiation stage (presenting epithelial−mesenchymal transition, EMT).
María José López-Grueso, Raúl González, Jordi Muntané, José Antonio Bárcena, C. Alicia Padilla   +4 more
doaj   +1 more source

Cold atmospheric plasma‐mediated tumor microenvironment remodeling for cancer treatment

BMEMat, EarlyView.
Schematic presentation of CAP‐mediated TME remodeling. This review summarizes recent efforts in cold atmospheric plasma (CAP) application in cancer treatment, highlighting the anticancer potential of CAP, molecular mechanisms, and future perspectives for further improvement and clinical translation.
Israr Khan, Qiujie Fang, Cao Fei, Ziyuan Wang, Zhaowei Chen, Guojun Chen, Zhiming Xu, Shu Xu, Zhitong Chen   +8 more
wiley   +1 more source