Results 181 to 190 of about 690,479 (320)

PATHOLOGICAL AND MORPHOLOGICAL STUDIES OF HEPATOCELLULAR CARCINOMA, PARTICULARLY ON METASTASES AND INTRACANAL TUMOR GROWTH

open access: bronze, 1979
Toshiro Nakashima   +19 more
openalex   +2 more sources

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

open access: yesAdvanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang   +15 more
wiley   +1 more source

Ectopic hepatocellular carcinoma in the gallbladder. [PDF]

open access: yesHepatobiliary Surg Nutr
Wan DL   +5 more
europepmc   +1 more source

Hepatic arterial injection chemotherapy with cisplatin suspended in an oily lymphographic agent for hepatocellular carcinoma [PDF]

open access: bronze, 1989
Junji Shibata   +5 more
openalex   +1 more source

Responsive ROS‐Augmented Prodrug Hybridization Nanoassemblies for Multidimensionally Synergitic Treatment of Hepatocellular Carcinoma in Cascade Assaults

open access: yesAdvanced Science, EarlyView.
This study proposes a novel HCC therapy using CA‐4S2@ES‐Cu nanomedicines to amplify cuproptosis, enhancing chemotherapy and immunotherapy. CA‐4 and ES‐Cu synergistically inhibit tumor growth, induce immune responses, and reverse the immunosuppressive microenvironment, offering an effective multidimensional therapeutic strategy for HCC treatment ...
Yingjie Zeng   +16 more
wiley   +1 more source

Novel ATR/PARP1 Dual Inhibitors Demonstrate Synergistic Antitumor Efficacy in Triple‐Negative Breast Cancer Models

open access: yesAdvanced Science, EarlyView.
Novel ATR/PARP1 dual inhibitors are developed for the first time. Advanced lead B8 effectively reduces cell viability in vitro and suppresses tumor growth in vivo, with better potency than ATRi and PARPi alone or in combination. Mechanistically, B8 induces apoptosis, arrests the cell cycle, and inhibits cancer cells colony formation, migration, and ...
Yuan Gao   +13 more
wiley   +1 more source

Nanomedicine‐Driven Modulation of Reductive Stress for Cancer Therapy

open access: yesAdvanced Science, EarlyView.
This article introduces a novel therapeutic paradigm that deliberately induces reductive stress within tumor cells to exploit their unique biochemical vulnerabilities. It systematically reviews the underlying biological mechanisms, current detection and monitoring techniques, and emerging advanced nanotechnology platforms specifically designed to ...
Yumin Mao   +8 more
wiley   +1 more source

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