Results 191 to 200 of about 2,029,665 (367)

Abnormal β‐Hydroxybutyrylation Modification of ARG1 Drives Reprogramming of Arginine Metabolism to Promote the Progression of Colorectal Cancer

Advanced Science, EarlyView.
Alterations in arginine metabolism and β‐hydroxybutyrylation (Kbhb) modifications play a critical role in tumor progression. This study reveals valuable insights into arginine metabolism reprogramming involving the ARG1‐Kbhb/P300/SLC3A2 signaling axis and uncovers an effective therapy combining BHB with ARG1 inhibitor through conventional enzymatic and
Chuman Lin, Zhiyang Li, Xiaotong Zhu, Wanbing Zhou, Xiansheng Lu, Jiali Zheng, Jie Lin   +6 more
wiley   +1 more source

Dual‐Targeted Nanovesicles Induced Cancer Stem‐Like Cell Differentiation to Sensitize Hepatocellular Carcinoma Radiotherapy

Advanced Science, EarlyView.
The existence of Pin1 and Notch1 crosstalk is identified and verified in HCC, and the crucial function of this crosstalk in sustaining the aggressive phenotypes of CSCs and radioresistance. A biomimetic nanovesicle is now developed to block the crosstalk between Pin1 and Notch1 for inducing CSCs differentiation and sensitizing HCC radiotherapy ...
Hongmei Cao, Qian Wang, Yanan Niu, Shuxiang Wang, Haixue Jia, Dianyu Wang, Jinjian Liu, Wei Yuan, Lijun Yang, Jianfeng Liu   +9 more
wiley   +1 more source

Hepatocellular carcinoma with sarcoma-like transformation A case report

, 1979
Tadashi Isomura, Masaaki Arakawa, Tatsuo Wada, Yutaka Shimokawa   +3 more
openalex   +2 more sources

TRIM21‐Mediated K11‐Linked Ubiquitination of ID1 Suppresses Tumorigenesis and Promotes Cuproptosis in Esophageal Squamous Cell Carcinoma

Advanced Science, EarlyView.
ID1 is regulated by E3 ligase TRIM21, which adds non‐degradative K11‐linked ubiquitin at Lys91, disrupting ID1‐TCF12 binding and freeing TCF12 to upregulate copper transporter SLC31A1. Enhanced SLC31A1 elevates intracellular copper, triggers cuproptosis, and inhibits ESCC growth.
Lei Li, Yuqing Wang, Ruoxi Tian, Tianshuo Yang, Yaxin Liu, Baoen Shan, Lianmei Zhao   +6 more
wiley   +1 more source

Reptilase test in cirrhosis and hepatocellular carcinoma. [PDF]

, 1977
Ronald D. Barr
openalex   +1 more source

Clinical Features, Molecular Biology, and the Metastatic Microenvironment in Lung Cancer Brain Metastases: Implications for Treatment Decisions

Advanced Science, EarlyView.
Brain metastases (BM) from lung cancer are aggressive with poor prognosis. This review covers clinical features, diagnosis, early metastasis, and multi‐omics‐elucidated mechanisms, especially the tumor microenvironment of lung cancer with BM. It also discusses preclinical models, signaling pathways, and emerging therapies.
Yixiang Zhu, Danming He, Zan Hou, Mei Lan, Ye Zhang, Qifeng Wang   +5 more
wiley   +1 more source

PATHOLOGICAL AND MORPHOLOGICAL STUDIES OF HEPATOCELLULAR CARCINOMA, PARTICULARLY ON METASTASES AND INTRACANAL TUMOR GROWTH

, 1979
Toshiro Nakashima, Masaaki Arakawa, Masamichi Kojiro, Kazuyoshi Sakamoto, T. Ikari, NAOYUKI OTSU, Hideki Kida, Masayuki Okabe, SADAAKI KUWAO, Naofumi Eriguchi, Hisamitsu Hidaka, Atsuo Jimi, Yoshiro Kawano, Yasunari Kumagaya, Keiko Tokuda, Tadashi Isomura, Ryusuke Yamaguchi, Masahiro Koga, KIYOHARU KABATA, Masayoshi Kage   +19 more
openalex   +2 more sources

Ferroptosis in hepatocellular carcinoma: mechanisms and targeted therapy

British Journal of Cancer, 2022
Amir Ajoolabady, D. Tang, G. Kroemer, Jun Ren   +3 more
semanticscholar   +1 more source

Macrophage‐Mediated Transport of Insoluble Indirubin Induces Hepatic Injury During Intestinal Inflammation

Advanced Science, EarlyView.
Plant‐derived bioactive molecules with low solubility and permeability induce hepatocyte injury, though the mechanisms driving their hepatic effects remain poorly understood. This study identifies a novel transport pathway in which poorly soluble indirubin accumulates in the liver via macrophage‐mediated uptake in Peyer's patches, exacerbating hepatic ...
Yiqi Xu, Jingchun Shi, Heung‐Lam Mok, Cheng Lyu, Junbang Chen, Chunhua Huang, Hongyan Qin, Chengyuan Lin, Hor‐Yue Tan, Zhaoxiang Bian   +9 more
wiley   +1 more source

Ultrastructure of Human Hepatocellular Carcinoma-Fine Structure of Blood Spaces (Tumor Vessels)

, 1979
Tadashi Isomura
openalex   +2 more sources