Results 241 to 250 of about 734,282 (319)

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Nanocomposites to Overcoming Sorafenib Resistance in Hepatocellular Carcinoma Therapy. [PDF]

Int J Nanomedicine
Liu J, Zhou S, Wei Y, Du J, Jia F, Dong W, Cao Y, Shi Z, Mu H, Chen L, Yu S.   +10 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

RETRACTION: Downregulation of CRABP2 Inhibit the Tumorigenesis of Hepatocellular Carcinoma in Vivo and in Vitro. [PDF]

Biomed Res Int
International BR.
europepmc   +1 more source

SLC35C2 promotes stemness and progression in hepatocellular carcinoma by activating lipogenesis

Chunhui Qi, Bin Cao, Zhiwen Gong, Weiyu Zhang, Pengfei Yang, Haorui Qin, Yan Zhao, Yingchun Chen   +7 more
openalex   +1 more source

The role of viruses other than the hepatitis B and C viruses in the etiology of hepatocellular carcinoma

, 2002
Sherri O. Stuver
openalex   +1 more source

Depletion of the RNA‐Editing Enzyme ADAR1 Invigorates the Antitumor Immunity of NK Cells

Advanced Science, EarlyView.
ADAR1 is upregulated in NK cells from melanoma patients, impairing their function. Its loss enhances NK cell tumor infiltration and cytotoxicity in vitro and in vivo. Mechanistically, ADAR1 deficiency destabilizes CD38 mRNA to reduce its expression, thereby increasing NK cell mobility and killing, which nominates it as a therapeutic target for NK cell ...
Shuhan Chen, Di Lu, Rukang Liang, Weikeng Tan, Erming Zhao, Sihuang Wu, Xintong Li, Yulong Song, Miaojian Wan, Xiaoyuan Xie, Qi Zhang, Qiuli Liu   +11 more
wiley   +1 more source

Advancing Hepatocellular Carcinoma Therapy with Next-Generation Molecular and Immunotherapeutics. [PDF]

J Hepatocell Carcinoma
Hassan M, Hussain I, Ahmad K, Zafar S, Khalid A, Haseeb M, Hussain N, Ghafar MA.   +7 more
europepmc   +1 more source