Results 291 to 300 of about 734,282 (319)

Targeted Degradation of eEF2K by a Structure‐Guided PROTAC Strategy for the Treatment of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
This study developed an eEF2K‐targeting PROTAC, A6, that efficiently degrades eEF2K in TNBC cells, inhibiting tumor growth in vitro and in vivo. To enhance tumor‐specific delivery, we engineered A6@ZIF‐8, a pH‐sensitive nanocarrier, which improved drug accumulation at tumor sites, offering a promising therapeutic strategy for TNBC through targeted ...
Shijun Cao, Changxin Zhong, Shilong Jiang, Yungui Li, Yang Xi, Mingxuan Xiao, Ting Jiang, Xiaoya Wan, Zonglin Chen, Xiaohui Yu, Yan Cheng   +10 more
wiley   +1 more source

Radiotherapy for Liver-Confined Hepatocellular Carcinoma in Elderly Patients with Comorbidity. [PDF]

Cancers (Basel)
Bae SH, Kim YS, Kim SG, Yoo JJ, Lee JM, Lim S, Jung JH, Kim CK.   +7 more
europepmc   +1 more source

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Hepatocellular Carcinoma: A Critical Complication in Patients Treated with Pyridoxal Phosphate. [PDF]

Neuropediatrics
Brands MM, de Puyraimond C, Gospe SM, Schiff MM, Jaeger B, Koot BG, Raphael MF, Lubout CM, Soto B, Delanne J, Imbard A, Zempel J, Kraal KC, Scheenstra R, Clayton PT.   +14 more
europepmc   +1 more source

Clinicopathologic and prognostic significance of TIAM2 overexpression in resected hepatocellular carcinoma. [PDF]

Future Sci OA
Lu J, Li L, Chen Q, Li B, Ren S, Yuan M, Meng M, Lei J, Bing Y, Wang H, Guo L, Ma Z, Xiu D, Yuan C.   +13 more
europepmc   +1 more source

Cannabidiol-Ion Channel Interactions Represent a Promising Preventive and Therapeutic Strategy in Hepatocellular Carcinoma. [PDF]

Pathophysiology
Chávez-López MG, Avalos-Fuentes A, Cruz-Manzo EDC, Aguirre-Arriaga PA, Florán B, Pérez-Carreón JI, Bañuelos C, Camacho J.   +7 more
europepmc   +1 more source

Response to the Comment on “Development and Validation of a Machine Learning‐Based Marker for Early Detection and Prognosis Stratification of Nonalcoholic Fatty Liver Disease”

Advanced Science, EarlyView.
Lushan Xiao, Lin Zeng, Jiaren Wang, Chang Hong, Li Liu   +4 more
wiley   +1 more source

Circular RNA in hepatocellular carcinoma: emerging therapeutic strategies. [PDF]

Front Immunol
Jazbec G, Režen T.
europepmc   +1 more source

Etiology of cirrhosis is associated with risk of hepatic decompensation and hepatocellular carcinoma. [PDF]

BMC Gastroenterol
Ng M, Bardhi O, Lai K, Koo E, Yekkaluri S, Bass K, Bhamra G, Danpanichkul P, Quirk L, Yang JD, Louissaint J, Kerr TA, Singal AG.   +12 more
europepmc   +1 more source