Results 61 to 70 of about 2,074,577 (363)

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Infiltration characteristics and regulatory mechanisms of CD8+ T lymphocytes in solid tumors: spatial distribution, biological functions, and interactions with the immune microenvironment

Frontiers in Immunology
CD8+ T lymphocytes are central effectors of anticancer immunity. Their abundance and spatial distribution within solid tumors are strongly correlated with patient prognosis and response to immune-checkpoint inhibitors (ICIs). Tumors have been categorized
Peng Ouyang, Peng Ouyang, Jianhong Zhang, Jianhong Zhang, Xiao He, Xiao He, Congcong Yang, Dingcheng Zeng, Daofeng Xu, Daofeng Xu   +9 more
doaj   +1 more source

Cancer-Testis Gene Expression in Hepatocellular Carcinoma: Identification of Prognostic Markers and Potential Targets for Immunotherapy

Technology in Cancer Research & Treatment, 2020
Background: Cancer-testis genes can serve as prognostic biomarkers and valuable targets for immunotherapy in multiple tumors because of their restricted expression in testis and cancer.
Yan-Peng Zhang MD, Zhi-Wei Bao PhD, Jing-Bang Wu PhD, Yun-Hao Chen PhD, Jun-Ru Chen PhD, Hai-Yang Xie PhD, Lin Zhou PhD, Jian Wu PhD, Shu-Sen Zheng PhD   +8 more
doaj   +1 more source

Contribution of galectin-1, a glycan-binding protein, to gastrointestinal tumor progression [PDF]

, 2017
Gastrointestinal cancer is a group of tumors that affect multiple sites of the digestive system, including the stomach, liver, colon and pancreas. These cancers are very aggressive and rapidly metastasize, thus identifying effective targets is crucial ...
Bacigalupo, Maria Lorena, Carabias, Pablo, Troncoso, María Fernanda   +2 more
core   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib

Molecular Oncology, EarlyView.
WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute, Júlia Huguet‐Pradell, Jordi Abril‐Fornaguera, Albert Gris‐Oliver, Alex Rialdi, Elisa Fernández‐Martínez, Carla Montironi, Vanessa Del Pozo, Peter Houghton, Laura Zanatto, Agavni Mesropian, Ieva Keraite, Swan Thung, Carolina Armengol, Pau Sancho‐Bru, Ernesto Guccione, Roser Pinyol, Josep M. Llovet   +17 more
wiley   +1 more source

Analysis of different prognoses in two hepatocellular carcinoma patients with pathological complete response after conversion therapy: a case report

Journal of Medical Case Reports
Background Hepatocellular carcinoma is a common lethal malignancy, with most patients diagnosed at an advanced stage, precluding surgical resection. Conversion therapy combining locoregional and systemic treatments has emerged as an effective approach to
Qinliang Fang, Yu Xiong, Yibin Zhang, Fuqiang Wang, Zhenyu Yin, Jianyin Zhou   +5 more
doaj   +1 more source

ONC206 targeting ClpP induces mitochondrial dysfunction and protective autophagy in hepatocellular carcinoma cells

Neoplasia: An International Journal for Oncology Research
Hepatocellular carcinoma (HCC) is the most common form of liver cancer, accounting for approximately 90 % of all cases. ONC201, a member of the imipridone drug family, has shown promising therapeutic potential and a good safety profile in both malignant ...
Jiahao Cao, Fei Cao, Chuanzheng Wang, Zhen Jiao, Yuting You, Xiaomin Wang, Wenxiu Zhao   +6 more
doaj   +1 more source

Overexpression of Cullin7 is associated with hepatocellular carcinoma progression and pathogenesis

BMC Cancer, 2017
Background Overexpression of Cullin7 is associated with some types of malignancies. However, the part of Cullin7 in hepatocellular carcinoma remains unclear. The aim of this study was to investigate the role of Cullin7 in pathogenesis and the progression
Jun An, Zhigang Zhang, Zhiyong Liu, Ruizhi Wang, Dayang Hui, Yi Jin   +5 more
doaj   +1 more source

Clinical features and diagnostic imaging of cholangiolocellular carcinoma compared with other primary liver cancers: a surgical perspective

Technology in Cancer Research & Treatment, 2020
Background and Objectives: Although cholangiolocellular carcinoma is considered a combined hepatocellular and cholangiocarcinoma, we feel that this classification is not appropriate.
Hiroyuki Takamura PhD, MD, Ryousuke Gabata MD, Yoshinao Obatake PhD, MD, Shinichi Nakanuma PhD, MD, Hironori Hayashi PhD, MD, Kazuto Kozaka PhD, MD, Motoko Sasaki PhD, MD, Mitsuyoshi Okazaki PhD, MD, Takahisa Yamaguchi PhD, MD, Hiroyuki Shimbashi PhD, MD, Shiro Terai PhD, MD, Koichi Okamoto PhD, MD, Isamu Makino PhD, MD, Jun Kinoshita PhD, MD, Keishi Nakamura PhD, MD, Tomoharu Miyashita PhD, MD, Hidehiro Tajima PhD, MD, Itasu Ninomiya PhD, MD, Sachio Fushida PhD, MD, Azusa Kitao PhD, MD, Masaaki Kitahara PhD, MD, Kuniaki Arai PhD, MD, Taro Yamashita PhD, MD, Tatsuya Yamashita PhD, MD, Hiroko Ikeda PhD, MD, Yasunori Satoh PhD, MD, Kenichi Harada PhD, MD, Syuichi Kaneko PhD, MD, Toshihumi Gabata PhD, MD, Tateo Kosaka PhD, MD, Tetsuo Ohta PhD, MD   +30 more
doaj   +1 more source