Results 141 to 150 of about 58,347 (252)

Systemic Brain Delivery of Oligonucleotide Therapeutics Enhanced by Protein Corona‐Assisted DNA Cubes

Small Methods, EarlyView.
In vivo, screening of DNA nanostructures yields a cube‐shaped structure (D‐Cb) as a protein corona‐assisted platform for brain delivery of oligonucleotide therapeutics. D‐Cb effectively delivers polo‐like kinase 1 (PLK‐1) antisense oligonucleotides (ASO) to treat glioblastoma in an orthotopic mouse model, demonstrating its potential as a carrier for ...
Kyoung‐Ran Kim, Ji Hee Kang, Hien Bao Dieu Thai, Ji Hyun Back, Chengde Mao, Ji Eun Lee, Young Tag Ko, Dae‐Ro Ahn   +7 more
wiley   +1 more source

Research progress on AMPK in the pathogenesis and treatment of MASLD. [PDF]

Front Immunol
Feng J, MengHuan L, TingTing Y, XueJie Y, HaiNing G.   +4 more
europepmc   +1 more source

Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components

Small Methods, EarlyView.
The review presents a comprehensive overview of each component of lipid nanoparticles（LNPs）and their effects on editing efficiency. It specifically highlights strategies for achieving non‐liver delivery, aiming for broader applications in gene editing. Furthermore, this review summarizes the applications of LNPs in gene editing and offers insights for ...
Fan Wu, Nei Li, Yudian Xiao, Rohan Palanki, Hannah Yamagata, Michael J. Mitchell, Xuexiang Han   +6 more
wiley   +1 more source

Beneficial Effects of Infiltration of Platelet-Rich Plasma in the Endometrium. [PDF]

Biology (Basel)
Alonso-Frías P, Francés-Herrero E, Bueno-Fernandez C, Gómez-Álvarez M, Agustina-Hernández M, Cervelló I, Cozzolino M.   +6 more
europepmc   +1 more source

Manipulation of Wnt/β‐Catenin Signaling by Synthetic Frizzled Agonist and LRP Antagonist in Organoid Cultures and In Vivo

Small Methods, EarlyView.
Harnessing synthetic key receptor modulators, this study presents a breakthrough in Wnt/β‐catenin regulation. The FZD agonist RRP‐pbFn bypasses LRP5/6 to drive organoid expansion and tissue regeneration, while the LRP antagonist RRP‐Dkk1c eradicates tumors. These tools enable precise pathway control, advancing regenerative and cancer therapies.
Quanhui Dai, Jiawen Wang, Zihuan Lin, Danni Yu, Hui Yang, Jinsong Wei, Xiaoyu Li, Hao Hu, Chao Ni, Bing Zhao   +9 more
wiley   +1 more source

Network pharmacology-based investigation of the pharmacological mechanisms of diosgenin in nonalcoholic steatohepatitis. [PDF]

Sci Rep
Gu P, Chen J, Xin J, Chen H, Zhang R, Chen D, Zhang Y, Shao S.   +7 more
europepmc   +1 more source

Unveiling the complex extra‐oral colonization pathways and pathogenic mechanisms of Fusobacterium nucleatum, a heterogeneous oral pathogen

VIEW, EarlyView.
We summarize the taxonomic characteristics, capabilities to adhere to and invade host cells, extra‐oral ectopic colonization pathways, and major pathogenic mechanisms of Fusobacterium nucleatum, and explore the regulation of F. nucleatum’s pathogenesis, aiming to provide references and assistance for the development of clinical interventions and future
Zhiwei Guan, Houbao Qi, Qiang Feng
wiley   +1 more source

Constitutive androstane receptor, liver pathophysiology and chemical contaminants: current evidence and perspectives. [PDF]

Front Endocrinol (Lausanne)
De Battistis F, Djordjevic AB, Saso L, Mantovani A.   +3 more
europepmc   +1 more source

Analysis of the Functional Role of TIMM29 in the Hepatitis B Virus Life Cycle

Microbiology and Immunology, Volume 69, Issue 4, Page 229-246, April 2025.
ABSTRACT Hepatitis B virus (HBV) causes chronic hepatitis B, which can progress to liver cirrhosis and hepatocellular carcinoma. HBV has complex interactions with various cell organelles and proteins that ensure effective progeny virus production. We previously reported that a mitochondrial protein, TIMM29, should regulate the HBV life cycle through ...
Limia Abueldahab, Yadarat Suwanmanee, Nelly Muriungi, Eriko Ohsaki, Masami Wada, Shihoko Kimura‐Ohba, Keiji Ueda   +6 more
wiley   +1 more source

Thyroid metastasis from ovarian clear cell carcinoma. [PDF]

Endocrinol Diabetes Metab Case Rep
Sasaki R, Yamazaki H, Kumagai E, Toda S, Saito A.   +4 more
europepmc   +1 more source