Results 251 to 260 of about 89,971 (313)

Insights Into Macrophage Ferroptosis: Implications for Atherosclerosis

Cell Proliferation, EarlyView.
Macrophage ferroptosis drives atherosclerosis by enhancing oxidative stress and inflammation, accelerating plaque progression and instability. Targeting macrophage ferroptosis presents a promising therapeutic strategy for atherosclerosis treatment.
Xiehui Chen, Xiangbo Liu, Changchun Zeng
wiley   +1 more source

Moderate increase of MET in hepatocytes protects against cholestatic liver injury by promoting an effective antioxidant response

The FEBS Journal, EarlyView.
Moderate overexpression of wild‐type Met in hepatocytes (Alb‐R26Met mouse model) boosts a strong antioxidant response dependent on the glutathione system while impairing TGF‐β signaling in the liver. This leads to improved liver regeneration and protects against DDC‐induced injury, a model for cholestatic disease sharing features with primary ...
Carlos González‐Corralejo, Juan García‐Sáez, María Figueroa‐Fuentes, Annalisa Addante, Cesáreo Roncero, Nerea Lazcanoiturburu, Beatriz Pacheco, Julián Sanz, Cristina Gato, Eva Fernández‐Calderón, María de la O López, Águeda González‐Rodríguez, Almudena Porras, Flavio Maina, Isabel Fabregat, Blanca Herrera, Aránzazu Sánchez   +16 more
wiley   +1 more source

Orphan Nuclear Receptors in Metabolic Dysfunction-associated Steatotic Liver Disease Development. [PDF]

J Clin Transl Hepatol
Li H, Chen J, Huang Z, Chen M.
europepmc   +1 more source

Sacubitril/Valsartan Attenuates Inflammation and Fibrosis Associated With Decreased Integrin α8 and Inhibits Hepatocarcinogenesis in a Rat Model of Metabolic Dysfunction‐Associated Steatohepatitis

Hepatology Research, EarlyView.
Sacubitril/Valsartan (Sac/Val) alleviates fibrosis and inflammation in metabolic dysfunction‐associated steatohepatitis (MASH). Its anti‐fibrotic effect is linked to the suppression of Integrin alpha 8 (Itga8), a protein crucial for hepatic stellate cell (HSC) activation and collagen production.
Hayato Kawamura, Aya Naiki‐Ito, Xiaochen Kuang, Akihiro Murakami, Masayuki Komura, Takanori Suzuki, Hiroyuki Kato, Yuko Nagayasu, Kentaro Matsuura, Kei Fujiwara, Hiromi Kataoka, Satoru Takahashi   +11 more
wiley   +1 more source

Neutrophil-Mimicking Prussian blue nanozymes for synergistic targeted immuno-metabolic therapy of hepatic ischemia-reperfusion injury. [PDF]

J Nanobiotechnology
Shen P, Huang K, Zhang X, Qin M, Wang X, Fan Z.   +5 more
europepmc   +1 more source

Hepatocyte growth factor alleviates alcoholic cardiomyopathy through the Nrf2 pathway-a focus on iron metabolism. [PDF]

J Thorac Dis
Yu Y, Chen J, Cao K, Zhang J.
europepmc   +1 more source

Aflatoxin Mixture-Driven Intrahepatic Cholangiocarcinoma in Rats Involving G1/S Checkpoint Dysregulation. [PDF]

Toxins (Basel)
Braga VM, Pereira PHF, Apolinario LA, Longo DMS, Ramalho LNZ, Ali S, Oliveira CAF, Ramalho FS.   +7 more
europepmc   +1 more source

Inhibition of Wnt signaling in primary human hepatocytes promotes Plasmodium falciparum liver stage development. [PDF]

PLoS Pathog
Kanyal A, van Gemert GJ, Wu H, van der Starre A, de Wilt JHW, Bousema T, Sauerwein RW, Bártfai R, Yang ASP.   +8 more
europepmc   +1 more source

Zn glycine mitigates the LPS-induced hepatic injury and inflammation through NrF2/NFκB signaling in geese. [PDF]

Poult Sci
Zulfiqar Z, Asif MA, Al-Mitib L, Alharbi K, Hossain T, Yao H, Zhu X, Wang Z, Sun H, Cui Y, Liu B, Shi Y.   +11 more
europepmc   +1 more source

Fibrinogen superfamily proteins: Key regulators in hepatic disorders. [PDF]

World J Exp Med
Qu RH, Rong Y, Ni WZ, Huang XL, Chen YZ, Li HF.   +5 more
europepmc   +1 more source