Results 101 to 110 of about 37,879 (224)

MPIG6B Gene-Related Myelofibrosis: A Rare Inherited Disease That Is Frequently Described in Arab Population

Avicenna Journal of Medicine
The megakaryocyte and platelet inhibitory receptor gene G6P (MPIG6B) is located on chromosome 6p21.33. It encodes G6b-B; an inhibitory receptor expressed on the surface of platelets. It regulates platelets production, aggregation, and activation.
Leen Jihad Attar, Almothana Alelaimat, Alaa Alshorman, Tariq N. Aladily   +3 more
doaj   +1 more source

Hypertriglyceridemia: Causes, Consequences, Diagnosis, and Management

MedComm, Volume 7, Issue 10, October 2026.
Hypertriglyceridemia (HTG) arises from the interplay between genetic susceptibility and secondary or precipitating factors, leading to dysregulated triglyceride‐rich lipoprotein (TRL) metabolism. Increased TRL production and impaired clearance promote distinct risk phenotypes: accumulation of apolipoprotein B(apoB)‐containing TRL remnants contributes ...
Shanshan Qi, Weiwei Chen, Kunhao Chen, Song Yang, Sibo Wang, Tongtian Ni, Dan Xu, Enqiang Mao, Erzhen Chen, Ying Chen   +9 more
wiley   +1 more source

Iron and Other Metal Ions in Human Health and Disease

MedComm, Volume 7, Issue 10, October 2026.
Iron, copper, zinc, and calcium orchestrate cellular function through distinct yet cooperative mechanisms: redox‐active iron and copper cycle between oxidation states to act as Fenton catalysts and electron carriers in oxidative phosphorylation (OXPHOS); redox‐inert zinc serves as a structural component of zinc‐finger proteins and a catalytic cofactor ...
Xiaofeng Dai, Jitian Li
wiley   +1 more source

G Protein‐Coupled Receptor in High‐Altitude Diseases: Mechanistic Insights and Therapeutic Opportunities

MedComm, Volume 7, Issue 10, October 2026.
High‐altitude hypobaric hypoxia activates multiorgan GPCR signaling networks that regulate ventilatory responses, cerebral endothelial barrier integrity, erythropoiesis and red blood cell metabolism, pulmonary vascular remodeling, and cardiac adaptation. Dysregulated GPCR pathways contribute to acute and chronic high‐altitude diseases, while clinically
Qing Zhao, Changliang Liu, Lu Dai, Kun Zheng, Kun Liang, Chuanling Pan, Lianhua Liu, Ling Chen, Xuefei He, Hui Yan, Lei Chen, Huaping Zheng, Cheng Deng, Fengming Luo   +13 more
wiley   +1 more source

Novel NLRC4 Mutation Causes a Syndrome of Perinatal Autoinflammation With Hemophagocytic Lymphohistiocytosis, Hepatosplenomegaly, Fetal Thrombotic Vasculopathy, and Congenital Anemia and Ascites

, 2017
Autoinflammatory diseases are caused by pathologic activation of the innate immune system. Primary hemophagocytic lymphohistiocytosis (HLH) is an aggressive syndrome of excessive immune activation caused by monogenic mutations resulting in cytotoxic ...
Jiancong Liang, Melissa M Riley, Suneeta Madan-Kheterpal, Julia Kofler, James E Squires, W Tony Parks, Danielle N Alfano, Jennifer Picarsic, Areeg El-Gharbawy, Roxanne Acquaro   +9 more
core   +1 more source

Peptide‐Enabled Nanoplatforms for Malaria and Leishmaniasis: From Intracellular Targeting to Translational Diagnostic Perspectives

ChemMedChem, Volume 21, Issue 18, 28 September 2026.
Peptide‐enabled nanoplatforms offer multifunctional strategies for the treatment and diagnosis of malaria and leishmaniasis. Liposomal, polymeric, and metallic nanocarriers, together with cell‐penetrating peptides and parasite‐derived mimotopes, can improve targeted drug delivery, stability, bioavailability, and intracellular localization.
Christian S. Carnero Canales, Ana Clara Lunardi Yagi, Túlio Custódio Reis, Jessica Ingrid Cazorla, Jade Rojas Villar, Marcia A. Graminha, Roxana Yesenia Pastrana Alta, Fernando Rogério Pavan   +7 more
wiley   +1 more source

Ichthyosis, hepatosplenomegaly, and cerebellar degeneration in a sibship

, 1979
SUMMARY A sibship is described in which at least two brothers suffer from a unique disorder characterised by ichthyosis, hepatosplenomegaly, and late onset cerebellar ataxia. The clinical features and investigations are described.
P S Harper, I D Young, P J Dykes, R Marks   +3 more
core  

Capecitabine but not 5-FU worsened hepatosplenomegaly and liver function when used with oxaliplatin and cetuximab as first-line treatment in K-ras wild-type metastatic colorectal cancer

, 2013
Background: MRC COIN study showed that OXA and CAP (CAPOX) have greater toxicities compared with OXA and 5-FU (FOLFOX) when cetuximab (C225) was added for mCRC. Meanwhile, OXA was associated with splenomegaly and hepatic sinusoidal injury.
Lee, VHF, Ho, GCL, Lam, KO, Cheng, TKC, Zheng, S, Fang, WJ, Ho, PPY, Ng, SCY, Leung, TW, Choi, CW, Kwong, DLW, Liu, RKY   +11 more
core   +1 more source

Etat fébrile et Hépatosplénomégalie chez une femme de 25 ans: approche diagnostique [A 25-year-old woman with fever and hepatosplenomegaly: diagnostic approach]

, 2006
We proceeded to an extensive etiologic search in a young women with a hepatosplenomegaly and a chronic persistent fever.
Chabanel, D., Lamoth, F., Waeber, G.
core   +1 more source

Hepatosplenomegaly [PDF]

Proceedings of the Royal Society of Medicine, 1947
J. P. M. Tizard, Donald Paterson
openaire   +2 more sources