Results 91 to 100 of about 3,018 (199)

Phenotype analysis of families with TP53 germline variants at the Center for Familial Breast and Ovarian Cancer, Cologne

Cancer Medicine, Volume 13, Issue 3, February 2024.
TP53‐associated tumor syndrome is a rare predisposition syndrome. Our analysis of the tumor spectrum and age of onset in 35 index patients supports the evidence for a less severe phenotype in families identified by gene panel testing for hereditary breast and ovarian cancer. Abstract Purpose Tumor protein p53 (TP53) pathogenic variant (PV) carriers are
K. Kast, K. Rhiem, M. Larsen, B. Wappenschmidt, R. Schmutzler   +4 more
wiley   +1 more source

EGFR/erB-1, HER2/erB-2, CK7, LP34, Ki67 and P53 expression in preneoplastic lesions of bronchial epithelium: an immunohistochemical and genetic study [PDF]

, 2011
A prognostic interpretation of preneoplastic lesions would have impact in bronchial carcinoma early diagnosis and through the study of Erb-B family receptors as they have an important role in lung carcinogenesis. The existence of drugs as tyrosine kinase
Alarcão, AM, Cabral, T, Carvalho, L, Couceiro, P, Espírito Santo, J, Gomes, A, Silva, M, Sousa, V   +7 more
core   +1 more source

Assessment of Tissue Eosinophilic Infiltration in Invasive Mammary Carcinoma

International Journal of Breast Cancer, Volume 2024, Issue 1, 2024.
Background: Stromal inflammatory cells in malignant tissue have recently gained increasing interest. Unlike the extensive research on tumor‐infiltrating lymphocytes, published data about tumor‐infiltrating eosinophils in breast cancer are scarce. Furthermore, similar studies have yet to be conducted in Iraq.
Farah Falah Hasan, Mohammed Haider Fadhil, Zainab Khalid Almukhtar, Ivana Ribeiro   +3 more
wiley   +1 more source

Оценка патоморфоза после неоадъювантной терапии рака молочной железы [PDF]

, 2019
МОЛОЧНОЙ ЖЕЛЕЗЫ НОВООБРАЗОВАНИЯРАК МОЛОЧНОЙ ЖЕЛЕЗЫНЕОАДЪЮВАНТНАЯ ТЕРАПИЯЛЕЧЕБНЫЙ ПАТОМОРФОЗЦель – систематизировать имеющиеся данные о лечебном патоморфозе опухоли молочной железы после неоадьювантной системной терапии (НАТ).
Ачинович, С. Л., Ганусевич, О. Н., Нестерович, Т. Н., Федоркевич, И. В.   +3 more
core  

Correlation between grade of the tumour and HER2NEU status in breast cancer.

The Professional Medical Journal
Objective: To evaluate the distribution of histological grades of breast cancer and its association with HER2/neu expression. Study Design: Cross-sectional study. Period: March 2024 to August 2024. Setting: Oncology, Jinnah Postgraduate Medical Center, Karachi, Pakistan.
null Faiza Mahar, null Ghulam Haider, null Priyanka, null Saima Zahoor   +3 more
openaire   +1 more source

Loss of Trop2 causes ErbB3 activation through a neuregulin-1-dependent mechanism in the mesenchymal subtype of HNSCC [PDF]

, 2014
In head and neck squamous cell cancer (HNSCC), four intrinsic subtypes (or groups) have been identified, and each one possesses a unique biology that will require specific treatment strategies.
Adkins, Douglas, Chung, Christine H., Ellis, Matthew J., Fertig, Elana J., Herrlich, Andreas, Jones, Lamont, Kimple, Randall J., Lewis, James, Lim, Sora, Maher, Christopher A., Michel, Loren S., Van Tine, Brian A., Zhang, Kaihua   +12 more
core   +3 more sources

The Risk of Toxicities from Trastuzumab, Alone or in Combination, in an Elderly Breast Cancer Population [PDF]

, 2013
Background: Breast cancer in the elderly is associated with high recurrence and death rates, due mostly to undertreatment. Human epidermal growth factor receptor type 2 (HER2) overexpression is infrequent in older patients.
Adamo, B., Adamo, V., Caristi, N., Cicero, G., Ferraro, G., Franchina, T., Ricciardi, G., Rizzo, S., Rossello, R., Russo, A., Zanghi, M.   +10 more
core   +1 more source

Monitoring Therapy by Serum HER-2/Neu

The International Journal of Biological Markers, 2000
We have evaluated the performance of the Bayer Immuno 1™ serum HER-2/neu assay. The precision is excellent and varied between 1.7% and 2.1% at values of HER-2/neu ranging from 16.8 ng/mL to 108.6 ng/mL.
M.K. Schwartz MD, C. Smith, D.C. Schwartz, A. Dnistrian, I. Neiman   +4 more
doaj   +1 more source

Not only P-glycoprotein: amplification of the ABCB1-containing chromosome region 7q21 confers multidrug resistance upon cancer cells by coordinated overexpression of an assortment of resistance-related proteins [PDF]

, 2017
The development of drug resistance continues to be a dominant hindrance toward curative cancer treatment. Overexpression of a wide-spectrum of ATP-dependent efflux pumps, and in particular of ABCB1 (P-glycoprotein or MDR1) is a well-known resistance ...
Assaraf, Yehuda G., Colotti, Gianni, Fazi, Francesco, Genovese, Ilaria, Ilari, Andrea   +4 more
core   +1 more source

Breast Cancer Patients with Her2neu Overexpression: Relationship among Clinicopathological Characteristics and Local/Distant Recurrences and Survival

Annals of Oncology, 2012
ABSTRACT Objectives The aim of this study was to correlate the overexpression of HER2 with clinical pathologic characteristics and its influence on local/distant recurrence and survival. Methods From 1998 to 2010, prospective data of 146 patients with invasive breast cancer with HER-2 overexpression was studied. The sample was divided into three
C. Bellido-Ribes, S. Gonzalez, A. Garcia, V. Obadia, R. Bastus, J. Fernández, A. Aguilar, L. Cirera   +7 more
openaire   +1 more source