Results 151 to 160 of about 3,222,626 (259)

Breast-Ovarian Hereditary Cancer Syndrome: Beyond <i>BRCA1</i> and <i>BRCA2</i>. [PDF]

Curr Oncol
Imyanitov E, Sokolenko A.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The evolution of hereditary cancer genetic counselling: mainstreaming, service redesign and patient experience in Lynch syndrome. [PDF]

Fam Cancer
Kohut K, Cable S, Ashokan A, Vicari S, Ditchfield H, Young J, Bux B, Lalloo F.   +7 more
europepmc   +1 more source

Cancer Trends: non-Hodgkin’s lymphoma (NHL)

, 2013
An average of 660 cases of non Hodgkin’s lymphoma (NHL) was diagnosed per year in Ireland between 2007 and 2011 (Table 1). Incidence rates were slightly higher in males than in females where NHL was the 5th and 8th most common cancer diagnosed ...
National Cancer Registry Ireland (NCRI)
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Fertility desires and outcomes in patients with selected hereditary cancer syndromes. [PDF]

Gynecol Oncol Rep
Connelly EA, Lowry CM, Camara C, Wei J, Garcia C.   +4 more
europepmc   +1 more source

Meeting abstracts from the Annual Conference on Hereditary Cancers 2016

Hereditary Cancer in Clinical Practice, 2017
C. Cybulski, W. Kluźniak, T. Huzarski, D. Wokołorczyk, A. Kashyap, A. Jakubowska, M. Szwiec, T. Byrski, T. Dębniak, B. Górski, V. Sopik, M. R. Akbari, P. Sun, J. Gronwald, S. A. Narod, J. Lubiński, T. Dębniak, D. Dymerska, G. Kurzawski, J. Lubiński, D. Dymerska, K. Tutlewska, M. Kuswik, H. Rudnicka, R. J. Scott, R. Billings, A. Pławski, J. Lubinski, G. Kurzawski, T. Gromowski, K. Kąklewski, W. Marciniak, K. Durda, M. Lener, G. Sukiennicki, K. Kaczmarek, K. Jaworska-Bieniek, K. Paszkowska-Szczur, P. Waloszczyk, J. Lubiński, T. Dębniak, J. Gronwald, K. Hemminki, A. Försti, T. Huzarski, J. Gronwald, C. Cybulski, O. Oszurek, M. Szwiec, K. Gugała, M. Stawicka, Z. Morawiec, T. Mierzwa, M. Falco, H. Janiszewska, E. Kilar, E. Marczyk, B. Kozak-Klonowska, M. Siołek, D. Surdyka, R. Wiśniowski, M. Posmyk, P. Domagała, T. Byrski, P. Sun, J. Lubiński, S. A. Narod, Polish Breast Cancer Consortium, E. N. Imyanitov, K. Kaczmarek, M. Muszyńska, W. Marciniak, G. Sukiennicki, M. Lener, K. Durda, K. Jaworska-Bieniek, T. Gromowski, K. Prajzendanc, N. Peruga, T. Huzarski, T. Byrski, J. Gronwald, C. Cybulski, T. Dębniak, A. Morawski, A. Jakubowska, J. Lubiński, M. R. Lener, R. J. Scott, W. Kluźniak, J. Gronwald, P. Baszuk, C. Cybulski, A. Wiechowska-Kozłowska, T. Huzarski, J. Kładny, S. Pietrzak, A. Soluch, A. Jakubowska, J. Lubiński, A. Plawski, K. Prajzendanc, A. Jakubowska, J. Lubiński, U. R. Rashid, H. Naeemi, N. Muhammad, J. Lubiński, A. Jakubowska, A. Loya, M. A. Yusuf, A. Savanevich, O. Aszurek, J. Gronwald, J. Lubiński, A. Mathe, M. Wong-Brown, W. Locke, C. Stirzaker, S. G. Braye, J. F. Forbes, S. Clark, K. Avery-Kiejda, R. J. Scott, J. Tomiczek-Szwiec, T. Huzarski, M. Szwiec, J. Gronwald, C. Cybulski, E. Marczyk, J. Jakubowicz, E. Kilar, R. Sibilski, M. Stawicka, Z. Morawiec, T. Mierzwa, M. Falco, H. Janiszewska, B. Kozak-Klonowska, M. Siołek, D. Surdyka, R. Wiśniowski, R. Posmyk, P. Domagała, J. Lubiński, M. Szwiec, J. Tomiczek-Szwiec, T. Huzarski, C. Cybulski, J. Lubiński   +149 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Population Genomic Screening for Hereditary Cancer Risk: Patient Experience, Perceptions, and Downstream Clinical Outcomes. [PDF]

J Genet Couns
English S, Malphrus L, Norman S, Baker NL, Judge DP, Wagner I, Allen CG.   +6 more
europepmc   +1 more source