Results 151 to 160 of about 252,012 (266)

Real-world uptake of gBRCA testing as a companion diagnostic for olaparib in patients with high-risk HER2-negative early breast cancer in Japan: a cross-sectional multicenter study (BRCAwareness). [PDF]

Breast Cancer
Taji T, Uemura Y, Kimura Y, Maeda N, Ito A, Seki H, Takabatake D, Harao M, Nakamoto S, Matsunuma R, Koganezawa C, Iwamoto T, Mukai H, Kikawa Y.   +13 more
europepmc   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Primary care stakeholder perspectives on clinical implementation of patient-reported hereditary cancer risk-assessment. [PDF]

BMC Prim Care
Gurram A, Ibidapo T, Bereket S, Gimpel N, Day C, Pirzadeh-Miller S, Makhnoon S.   +6 more
europepmc   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

A Gut Feeling: Metastatic Colorectal Adenocarcinoma With Dirty Necrosis in a Young Adult Without Risk Factors. [PDF]

Cureus
Memari K, Reinoso E, Sizova A, Lazo LP, Williams S, Cohen P.   +5 more
europepmc   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source

Cancer history and cancer risk communication among Arab-American families: Perspectives of young Arab-Americans in Michigan. [PDF]

J Genet Couns
Abdel-Salam HM, Hanson EN, Delacroix E, Awwad R, Resnicow K, Marvin M.   +5 more
europepmc   +1 more source

Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach

FEBS Letters, EarlyView.
The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring, Jan de Jonge, Hans‐Peter Braun, Nils Rugen   +3 more
wiley   +1 more source

Interest in Genetic Testing for Hereditary Cancer Risk: Associations with Genetic Familiarity, Self-Efficacy, and Sociodemographics.

Public Health Genomics
Cameron DM, Dusic E, Theoryn TN, Beers F, Knerr S, Wang C, Bowen D, Swisher E.   +7 more
europepmc   +1 more source

Autonomic Nervous System Phenotyping Across Chronic Demyelinating Peripheral Neuropathies: A Comparative Study. [PDF]

J Peripher Nerv Syst
Bjelica B, Todorovic T, Bozovic I, Palibrk A, Jankovic V, Basta I, Peric S.   +6 more
europepmc   +1 more source