Results 191 to 200 of about 429,052 (284)

Rare case of osteochondroma in the spinous process of the fifth cervical vertebra in a pediatric patient with multiple hereditary exostoses. [PDF]

Int J Surg Case Rep
Aljesri MA, Issa M, Issa N.
europepmc   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Frequency of Founder Mutations in <i>BRCA1</i> and <i>BRCA2</i> Genes in Hereditary Breast Cancers in Poland vs. Other Countries. [PDF]

Cancers (Basel)
Kulikowska B, Panasiuk B, Posmyk R.
europepmc   +1 more source

Hereditary Factors in Adiposis Dolorosa (Dercum's Disease).

, 1963
Henry T. Lynch, William L. Harlan
openalex  

Pharmacokinetics of a high‐purity plasma‐derived factor X concentrate in subjects with moderate or severe hereditary factor X deficiency

, 2016
Steve Austin, C. J. Brindley, Kaan Kavaklı, M. Norton, Amy D. Shapiro, the FX Investigators Group   +5 more
openalex   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Knowledge, attitudes, and perceptions towards premarital screening among undergraduate university students in Chattogram district, Bangladesh: a cross-sectional study. [PDF]

BMC Public Health
Hossain D, Mohsin M, Jahan ST, Salma B, Jahan N, Barua A, Sayeed MA, Hasan MMU, Hoq MI.   +8 more
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

A Review of CEBPA's Role in Hereditary Leukemia. [PDF]

EJHaem
Rakiewicz T, Palmisiano N.
europepmc   +1 more source

Hereditary factor XIII deficiency.

Indian pediatrics, 1988
M Y, Nitsure, S R, Karve, R S, Wadia, K B, Grant   +3 more
openaire   +1 more source