Results 111 to 120 of about 191,909 (291)
The normal iron content of the body is 3---4 g. It exists in hemoglobin, in iron-containing proteins different to hemoglobin, in iron bound to transferrin in plasma, and in the form of ferritin and hemosiderin.
Marfil Rivera, Luis Javier
core +1 more source
ABSTRACT Background We sought to determine associations of serum ferritin (SF) with live birth numbers and other iron‐related variables in women with HFE p.C282Y (rs1800562) homozygosity. Methods We studied non‐pregnant, non‐Hispanic white women in post‐screening evaluations to determine associations of SF with age, pregnancy and live birth numbers ...
James C. Barton+2 more
wiley +1 more source
HLA and hemochromatosis disease association in São Miguel Island [PDF]
Mestrado em Biologia Molecular e CelularA hemocromatose hereditária uma doença autossómica recessiva do metabolismo do ferro, geralmente associada à mutação C282Y no gene HFE. Presume-se que a origem desta mutação tenha ocorrido por acaso no haplótipo
Gomes, Cidália Maria Teixeira
core +1 more source
Ferroportin 1 is an iron exporter belonging to the Major Facilitator Superfamily. Its unusual intracellular gate is formed by asymmetric networks of non‐covalent bonds. We analyzed these networks using Molecular Dynamics simulations and experimental tests and identified novel amino acids as key players in inter‐lobe connections.
Marlène Le Tertre+8 more
wiley +1 more source
Hereditary hemochromatosis (HH) is a genetic disorder that causes excess absorption of iron and can lead to a variety of complications including liver cirrhosis, arthritis, abnormal skin pigmentation, cardiomyopathy, hypogonadism, and diabetes ...
Xiaomu Kong+6 more
doaj +1 more source
Mutações no gene HFE (C282Y, H63D, S65C) em uma população brasileira [PDF]
Hereditary hemochromatosis (HH) is the most common genetic disorder occurring in individuals of northern European descent. The clinical characteristic of this disease is the gradual accumulation of iron in internal organs, which ultimately leads to organ
Bueno, Simone+2 more
core +2 more sources
Iron chelation is a promising yet underexplored strategy for colorectal cancer (CRC) treatment. Iron chelators have a dual role in inhibiting and potentially promoting cancer progression. Iron chelation affects key CRC pathways, including histone methylation, NDRG1 upregulation, Wnt/β‐catenin, and p53 modulation.
Gihani Vidanapathirana+4 more
wiley +1 more source
Background The aim of this study was to evaluate the OpenArray platform for genetic testing of blood donors and to assess the genotype frequencies of nucleotide-polymorphisms (SNPs) associated with venous thrombosis (G1691A and G20210A ...
Vivian Dionisio Tavares Niewiadonski+4 more
semanticscholar +1 more source
Mutation Analysis in Hereditary Hemochromatosis
The DNA of 147 patients of European origin clinically diagnosed with idiopathic hemochromatosis and 193 controls was examined for mutations of the HLA-H gene at nt 845 and nt 187. One hundred twenty-one (82.3%) of the hemochromatosis patients were homozygous and 10 (6.8%) heterozygous for the 845A (C282Y) mutation.
Michele Adams+15 more
openaire +3 more sources
Given the frequent association between T2DM and the wide availability and administration of SGLT‐2i as a novel anti‐diabetic class on the one hand and hypogonadism with TRT on the other, concurrent administration may precipitate secondary erythrocytosis.
Maharan Kabha+5 more
wiley +1 more source