Results 91 to 100 of about 10,302 (227)

Hereditary Hemochromatosis and Iron Overload Disorders: A Clinical Review

, 2021
Iron is an essential micronutrient and a critical component of oxygen transport, numerous metabolic enzymes, and reaction centers of redox enzymes. Elevated iron can lead to iron accumulation in parenchymal organs, which can result in cardiac symptoms ...
Oliver, Deanna
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Do All Hemochromatosis Patients Have the Same Origin? A Pilot Study of Mitochondrial DNA and Y-DNA

Canadian Journal of Gastroenterology, 2011
BACKGROUND: Mitochondrial DNA (mtDNA) and Y-DNA analysis have been widely used to predict ancestral origin. Genetic anthropologists predict that human civilizations may have originated in central Africa one to two million years previously.
Caitlin J Symonette, Paul C Adams
doaj   +1 more source

The prevalence of primary hereditary hemochromatosis in central Anatolia

, 2013
Background/aims: Hereditary hemochromatosis is an autosomal recessive disorder associated with the HFE genes. Early identification and diagnosis is important as end stage organ damage may occur if treatment is delayed..
ÖZKUL, Yusuf, GÜVEN, Kadri, Onal, Muge, BAŞKOL, Mevlüt, GÜRSOY, Şebnem, Karaca, Halit   +5 more
core   +1 more source

Marcadores genéticos do MHC-Classe I na esteatohepatite não alcoólica

, 2009
Mestrado em Biologia Molecular e CelularO Fígado é o principal órgão regulador do metabolismo do ferro. Distúrbios relacionados com a sobrecarga de ferro podem ser devido a factores genéticos, como na HH com mutações conhecidas para o gene HFE, mas ...
Costa, Mónica Isabel Encarnação
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Genotypic and phenotypic spectra of hemojuvelin mutations in primary hemochromatosis patients: a systematic review

Orphanet Journal of Rare Diseases, 2019
Hereditary hemochromatosis (HH) is a genetic disorder that causes excess absorption of iron and can lead to a variety of complications including liver cirrhosis, arthritis, abnormal skin pigmentation, cardiomyopathy, hypogonadism, and diabetes ...
Xiaomu Kong, Lingding Xie, Haiqing Zhu, Lulu Song, Xiaoyan Xing, Wenying Yang, Xiaoping Chen   +6 more
doaj   +1 more source

Prevalence, Clinical Profiles, Disease Severity, and Patient Outcomes of Alcoholic Liver Disease in a Tertiary Care Hospital of Nepal

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Introduction Alcoholic liver disease (ALD) is an increasingly prevalent, chronic lifestyle‐related disease, which poses a significant global public health challenge. Timely detection and intervention are critical to reducing morbidity and mortality.
Bibek Joshi, Uma Challa, Aayush, Robert Hernandez, Kanchan Devkota, Priya Yadav, Rafael Jose Ramirez Dominguez, Anaya Jawad, Mohammed Abdul Mateen, Nagham Al Dirani   +9 more
wiley   +1 more source

Mouse models of hereditary hemochromatosis do not develop early liver fibrosis in response to a high fat diet.

PLoS ONE, 2019
Hepatic iron overload, a hallmark of hereditary hemochromatosis, triggers progressive liver disease. There is also increasing evidence for a pathogenic role of iron in non-alcoholic fatty liver disease (NAFLD), which may progress to non-alcoholic ...
John Wagner, Carine Fillebeen, Tina Haliotis, Edouard Charlebois, Angeliki Katsarou, Jeannie Mui, Hojatollah Vali, Kostas Pantopoulos   +7 more
doaj   +1 more source

Time-course analysis of serum hepcidin, iron and cytokines in a C282Y homozygous patient with Schnitzler’s syndrome treated with IL-1 receptor antagonist

Haematologica, 2009
It is currently unknown if the increase of the hepatic iron regulatory hormone hepcidin during inflammation in man depends on an intact HFE-protein. Here we describe the temporal relationship of serum hepcidin, serum iron and cytokines in a patient with ...
Marcel van Deuren, Joyce J. C. Kroot, Dorine W. Swinkels   +2 more
doaj   +1 more source

Dietary Index for Gut Microbiota and the Odds of Metabolic Dysfunction‐Associated Fatty Liver Disease in Overweight and Obese Children and Adolescents: A Cross‐Sectional Study

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Metabolic dysfunction‐associated fatty liver disease (MAFLD) is increasingly prevalent among children and adolescents with overweight or obesity, posing a growing public health challenge. Emerging evidence highlights the gut microbiota as a critical mediator in MAFLD pathogenesis, yet few studies have explored dietary ...
Farzam Kamrani, Ali Nikparast, Ali Tabatabaeyan, Elahe Etesami, Pejman Rohani, Golaleh Asghari   +5 more
wiley   +1 more source

Understanding Hereditary Hemochromatosis

, 2015
One of the most common genetic diseases, hereditary hemochromatosis is a disruption of iron regulation in the body. Its geographic distribution is worldwide, but it is most common in those of northern European origin.
Davidson, Kari
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