Results 101 to 110 of about 4,617 (234)

Effective gene expression in the rat dorsal root ganglia with a non-viral vector delivered via spinal nerve injection [PDF]

, 2016
Delivering gene constructs into the dorsal root ganglia (DRG) is a powerful but challenging therapeutic strategy for sensory disorders affecting the DRG and their peripheral processes.
Chang, Ming-Fong, Chao, Chi-Chao, Chellis, Luke A., Chiang, Hao, Hsieh, Jung-Hsien, Hsieh, Sung-Tsang, Huang, Cho-Min, Kan, Hung-Wei, Lin, Bo-Shiou, Miaw, Shi-Chuen, Pan, Chun-Liang   +10 more
core   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

High-density genotyping reveals signatures of selection related to acclimation and economically important traits in 15 local sheep breeds from Russia

BMC Genomics, 2019
Background Domestication and centuries of selective breeding have changed genomes of sheep breeds to respond to environmental challenges and human needs.
Andrey A. Yurchenko, Tatiana E. Deniskova, Nikolay S. Yudin, Arsen V. Dotsev, Timur N. Khamiruev, Marina I. Selionova, Sergey V. Egorov, Henry Reyer, Klaus Wimmers, Gottfried Brem, Natalia A. Zinovieva, Denis M. Larkin   +11 more
doaj   +1 more source

A Spaetzle-like role for Nerve Growth Factor β in vertebrate immunity to Staphylococcus aureus [PDF]

, 2014
Many key components of innate immunity to infection are shared between Drosophila and humans. However, the fly Toll ligand Spaetzle is not thought to have a vertebrate equivalent.
Antrobus, R, Blunde, T, Brown, K, Bryant,, C, Cachat, J, Connolly, J, Floto, R. A., Foster, S.J., Grogono, D. M., Hammond, K.L., Hegyi, K, Hepburn, L, Holden, M, Kaser, A, Klapholz, C, Ligoxygakis, P, Loynes, C, Minichiello, L, Moreno, P, Ny, T, Ochoa, B, Ogryzko, N.V., Otto, M, Peacock, S. J., Prajsnar, T.K., Renshaw, S.A., Schiebler, M, Seneviratne, S. L., Surewaard, B, Török, M. E., Wang, L, Woods, C. G.   +31 more
core  

Pharmacogenetics of analgesic drugs [PDF]

, 2013
• Individual variability in pain perception and differences in the efficacy of analgesic drugs are complex phenomena and are partly genetically predetermined.
Branford, R, Cregg, R, Gubbay, A, Russo, G, Sato, H   +4 more
core   +1 more source

Next‐Generation Strategies for Neural Repair and Regeneration: Neural Organoid Transplantation in the CNS

Cell Proliferation, EarlyView.
Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang, Jinrui Li, Xingjia Mao, Wanyu Wang, Yansong Li, Xuefei Hu, Jinjie Zhong, Fengdong Zhao, Linlin Wang   +8 more
wiley   +1 more source

Anestesia em paciente com insensibilidade congênita a dor e anidrose Anestesia en paciente con insensibilidad congénita al dolor y anhidrosis Anesthesia in a patient with congenital insensitivity to pain and anhidrosis

Revista Brasileira de Anestesiologia, 2009
JUSTIFICATIVA E OBJETIVOS: A insensibilidade congênita a dor e anidrose (ICDA) ou neuropatia hereditária sensorial e autonômica tipo IV (NHSA tipo IV) é neuropatia autossômica recessiva rara do grupo das neuropatias hereditárias sensoriais e autonômicas (
Carlos Rogério Degrandi Oliveira, Valter César Paris, Renato Augusto Pereira, Felipe Souza Thyrso de Lara   +3 more
doaj   +1 more source

Genetic neurological channelopathies: molecular genetics and clinical phenotypes [PDF]

, 2015
Evidence accumulated over recent years has shown that genetic neurological channelopathies can cause many different neurological diseases. Presentations relating to the brain, spinal cord, peripheral nerve or muscle mean that channelopathies can impact ...
Hanna, MG, Kullmann, DM, Spillane, J
core   +1 more source

Clinical practice of hereditary motor neuropathy (HMN) and hereditary sensory and autonomic neuropathy (HSAN)

Rinsho Shinkeigaku, 2014
Inherited neuropathy is a genetically and clinically heterogeneous group of neuropathies, the main category becomes Charcot-Marie-Tooth neuropathy (CMT), also known as hereditary motor and sensory neuropathy (HMSN), distal hereditary motor neuropathy (dHMN), and hereditary sensory autonomic neuropathy (HSAN). At least 80 genes have been associated with
openaire   +3 more sources

Advances in Electrocardiogram‐Based Non‐Invasive Blood Glucose Monitoring Technology

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Blood glucose monitoring is fundamental to diabetes management, yet traditional invasive methods are limited by patient discomfort and infection risks. In recent years, electrocardiogram (ECG), a conventional tool for cardiovascular assessment, has gained attention as a prospective method for non‐invasive blood glucose monitoring.
Qi Zeng, Jiaying Ni, Ziyi Zhang, Jinghao Cai, Jingyi Lu, Jian Zhou   +5 more
wiley   +1 more source