Results 111 to 120 of about 3,625 (203)

The 11-year Pittsburgh experience with liver transplantation for hepatocellular carcinoma: 1981-1991 [PDF]

, 1993
Experience with liver transplantation over a period of 11 years at the University of Pittsburgh is presented. The application of liver transplantation to cases of hepatocellular carcinoma has changed considerably over this 11-year period with the ...
Carr, B, Fung, JJ, Iwatsuki, S, Selby, RR, Starzl, TE, Van Thiel, DH   +5 more
core   +1 more source

Regulation of mammalian liver methionine adenosyltransferase [PDF]

, 2002
S-adenosylmethionine (SAM) is an essential metabolite in all cells. SAM is the most important biological methyl group donor and is a precursor in the synthesis of polyamines.
Avila, M.A. (Matías Antonio), Castro, C. (Carmen), Corrales, F.J. (Fernando José), Latasa, M.U. (María Ujué), Martinez-Chantar, M.L. (María Luz), Martinez-Cruz, L.A. (L. Alfonso), Mato, J.M. (José María), Perez-Mato, I. (Isabel), Ruiz Garcia-Trevijano, E. (Elena), Ruiz, F.A. (Félix A.), Sanchez-del-Pino, M.M. (Manuel M.)   +10 more
core   +1 more source

Identification of Novel Mutations in FAH Gene and Prenatal Diagnosis of Tyrosinemia in Indian Family [PDF]

, 2012
Carrier of tyrosinemia type I was diagnosed by sequencing FAH (fumarylacetoacetate hydrolase) gene. It leads to the identification of heterozygous status for both c.648C>G (p.Ile216Met) and c.1159G>A (p.Gly387Arg) mutations in exons 8 and 13 ...
Ankleshwaria, Chitra M., Pawar, Rajeshwari, Sheth, Frenny J., Sheth, Jayesh J.   +3 more
core   +2 more sources

Not So Rare: Errors of Metabolism during the Neonatal Period

, 2003
During the neonatal period, the diagnosis of an error of metabolism (EM) was once thought to portend a poor prognosis or lethality. Over the past two decades, the prognosis of many EMs has changed.
Banta-Wright, Sandra, Steiner, Robert D.
core   +1 more source

Hereditary Tyrosinemia Type 1 Mice under Continuous Nitisinone Treatment Display Remnants of an Uncorrected Liver Disease Phenotype. [PDF]

Genes (Basel), 2023
Neuckermans J, Lequeue S, Claes P, Heymans A, Hughes JH, Colemonts-Vroninks H, Marcélis L, Casimir G, Goyens P, Martens GA, Gallagher JA, Vanhaecke T, Bou-Gharios G, De Kock J.   +13 more
europepmc   +1 more source

Validation of Clinical-Grade Electroporation Systems for CRISPR-Cas9-Mediated Gene Therapy in Primary Hepatocytes for the Correction of Inherited Metabolic Liver Disease

Cells
Hepatocyte transplantation (HTx) combined with ex vivo gene therapy has garnered significant interest due to its potential for treating many inherited metabolic liver diseases.
Justin Gibson, Abishek Dhungana, Menam Pokhrel, Benjamin Arthur, Pramita Suresh, Olumide Adebayo, Renee N. Cottle   +6 more
doaj   +1 more source

Clinical and para clinical findings in the children with tyrosinemia referring for liver transplantation

International Journal of Preventive Medicine, 2013
Background: Hereditary tyrosinemia type 1 (HT1) is a rare autosomal recessive inborn error of metabolism caused by deficiency of fumarylacetoacetate hydrolase enzyme.
Seyed Mohsen Dehghani, Mahmood Haghighat, Mohammad Hadi Imanieh, Hossein Karamnejad, Abdorrasoul Malekpour   +4 more
doaj  

Directed protein evolution as a tool to innovate gene therapy for hereditary tyrosinemia type 1

, 2020
Jessie Neuckermans, Haaike Colemonts‐Vroninks, Lionel Marcélis, Alan Mertens, Ulrich Schwaneberg, Joery De Kock   +5 more
openalex   +1 more source

Liver Transplant for Children With Hepatocellular Carcinoma and Hereditary Tyrosinemia Type 1.

Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation, 2016
This study sought to determine the prevalence of hepatocellular carcinoma and other premalignant lesions in children with hereditary tyrosinemia type 1 who had undergone an orthotopic liver transplant at the Shiraz Transplant Center, in Shiraz, Iran.Between September 2006, and June 2011, thirty-six patients with hereditary tyrosinemia type 1 received a
Ali, Bahador, Seyed Mohsen, Dehghani, Bita, Geramizadeh, Saman, Nikeghbalian, Mohsen, Bahador, Seyed Ali, Malekhosseini, Kurosh, Kazemi, Heshmatolah, Salahi   +7 more
openaire   +1 more source

Opportunities and costs of clinical research. [PDF]

, 1985
Gavaler, JS, Starzl, TE, Tarter, R, Van Thiel, DH   +3 more
core   +1 more source