Results 161 to 170 of about 61,249 (214)

Weighted Burden Analysis of Rare Genetic Variants Identifies Novel Genes with Effects on BMI.

Hum Hered
Curtis D.
europepmc   +1 more source

Research on interdisciplinary measurement and evolutionary path in the field of ophthalmology. [PDF]

Front Ophthalmol (Lausanne)
Chunji L, Yuwei L, Fangyuan Z, Zihan N.
europepmc   +1 more source

Surface‐Capped Protein Nanoparticles for Nonviral Gene Delivery

Advanced Materials, Volume 38, Issue 20, 7 April 2026.
ABSTRACT Developing simple, safe, and efficient nonviral delivery systems remains a significant challenge in bioengineering. Nanoparticles offer promising gene delivery capabilities with reduced toxicity; however, long‐standing challenges related to effective plasmid encapsulation and delivery exist.
Fjorela Xhyliu, Yao Yao, Yeongun Ko, Grant Grasman, Jeffery E. Raymond, Albert Chang, Yuxuan Deng, Grant Dominic, Michael Triebwasser, Joerg Lahann   +9 more
wiley   +1 more source

Molecular Characterization of Two Hypertension Pedigrees Carrying Mitochondrial tRNAGln 4386T>C Mutation. [PDF]

Hum Hered
Luo Z, Lin J, Ji J, Zhang M.
europepmc   +1 more source

Compensatory Interplay Between Clarin‐1 and Clarin‐2 Deafness‐Associated Proteins Governs Phenotypic Variability in Hearing

Advanced Science, Volume 13, Issue 20, 9 April 2026.
Functional compensation between clarin‐1 and clarin‐2 in cochlear hair cells. Hearing loss associated with CLRN1 mutations shows striking phenotypic variability; however, the underlying mechanisms remain poorly understood. This study reveals that clarin‐1 and clarin‐2 function cooperatively in cochlear hair cells to sustain mechanoelectrical ...
Maureen Wentling, Aïda Yakhlef Sanchez, Nicolas Thelen, Müge Senarisoy, Maria Hogg, Steven Condamine, Andrea Lelli, Emilia Wysocka, Pranav Patni, Sandrine Vitry, Kerem Yasin Yildizhan, Sébastien Le Gal, Sylvie Nouaille, Michael R. Bowl, Marc Thiry, Didier Dulon, Sedigheh Delmaghani, Aziz El‐Amraoui   +17 more
wiley   +1 more source

Erzhi Tiangui formula increases the number of high-quality blastocysts in patients with advanced age by regulating the Nrf2/HO-1 signaling pathway: a randomized controlled study. [PDF]

J Ovarian Res
Xiufang L, Zhongqing W, Huidan W, Ye Z, Xu H, Wei C, Haicui W, Fang L.   +7 more
europepmc   +1 more source

Autosomal Dominant Erythrocytosis Caused by Non‐Renal Erythropoietin (EPO) Due to EPO c.‐136 G>A Germline Mutation

American Journal of Hematology, Volume 101, Issue 4, Page 784-793, April 2026.
A novel erythropoietin (EPO) promoter mutation (c.‐136 G>A) causes autosomal dominant erythrocytosis via non‐renal expression of EPO. ABSTRACT We previously reported a five‐generation kindred with autosomal dominant erythrocytosis associated with a novel germline promoter variant in the erythropoietin (EPO) gene (EPO c.‐136 G>A).
Lucie Lanikova, Dusan Hrckulak, Veronika Zimolova, Felipe R. Lorenzo, Jihyun Song, Katerina Vecerkova, Olga Babosova, Linda Berkova, Vladimir Korinek, Steve Elliott, Josef T. Prchal   +10 more
wiley   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, Volume 6, Issue 4, April 2026.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source

A reference genome for the rough limpet Lottia Scabra, an intertidal species from the northeastern Pacific. [PDF]

J Hered
Wutthituntisil N, Pedraza-Marrón CDR, DeBiasse MB, Escalona M, Fairbairn C, Marimuthu MPA, Nguyen O, Dawson MN.   +7 more
europepmc   +1 more source

Anticonvulsant Effects of Citronellal, Daidzin, and Phytol, Possibly Through GABAA Receptor and Voltage‐Gated Sodium Channel Interaction Pathways: In Vivo and In Silico Studies

Brain and Behavior, Volume 16, Issue 4, April 2026.
Citronellal, daidzin, and phytol exert significant anticonvulsant effects in a chick seizure model by enhancing GABAergic transmission and blocking voltage‐gated sodium channels, with combination therapies showing enhanced efficacy and a favorable safety profile.
Emon Mia, Md. Anisur Rahman, Md. Nasimul Haque Shipon, Moushumi Afroza Mou, Proma Mandal, Imam Hossen Rakib, Md. Abu Sayeed, Muhammad Torequl Islam, Md. Sakib Al Hasan, Mushtaq Ahmad Ansari   +9 more
wiley   +1 more source