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What does heritability of Alzheimer's disease represent?
PLoS ONE, 2023 IntroductionBoth late-onset Alzheimer's disease (AD) and ageing have a strong genetic component. In each case, many associated variants have been discovered, but how much missing heritability remains to be discovered is debated.
Emily Baker +14 more
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Optimal population size to detect quantitative trait loci in Korean native chicken: a simulation study [PDF]
Animal Bioscience, 2022 Objective A genomic region associated with a particular phenotype is called quantitative trait loci (QTL). To detect the optimal F2 population size associated with QTLs in native chicken, we performed a simulation study on F2 population derived from ...
Chiemela Peter Nwogwugwu +6 more
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Heritability estimation of osteoarthritis in the pig-tailed macaque (Macaca nemestrina) with a look toward future data collection [PDF]
PeerJ, 2014 We examine heritability estimation of an ordinal trait for osteoarthritis, using a population of pig-tailed macaques from the Washington National Primate Research Center (WaNPRC).
Peter B. Chi +3 more
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BMC Bioinformatics, 2021 Background Heritability is a central measure in genetics quantifying how much of the variability observed in a trait is attributable to genetic differences.
The Tien Mai +2 more
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BMI heritability and its relationship with puberty in 6 – 18-year-old twins
Zhongguo gonggong weisheng, 2023 ObjectiveTo analyze the heritability of body mass index (BMI) and the impact of puberty on the heritability among twins aged 6 – 18 years in Shandong province.
Tingting GUO, Yunjie BAI, Aiping FAN
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On Negative Heritability and Negative Estimates of Heritability [PDF]
Genetics, 2017 Abstract We consider the problem of interpreting negative maximum likelihood estimates of heritability that sometimes arise from popular statistical models of additive genetic variation. These may result from random noise acting on estimates of genuinely positive heritability, but we argue that they may also arise from ...
Steinsaltz, David +2 more
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Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. [PDF]
PLoS Genetics, 2013 Important knowledge about the determinants of complex human phenotypes can be obtained from the estimation of heritability, the fraction of phenotypic variation in a population that is determined by genetic factors.
Noah Zaitlen +6 more
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Statistical methods for SNP heritability estimation and partition: A review
Computational and Structural Biotechnology Journal, 2020 In GWAS studies, SNP heritability measures the proportion of phenotypic variance explained by all measured SNPs. Accurate estimation of SNP heritability can help us better understand the degree to which measured genetic variants influence phenotypes ...
Huanhuan Zhu, Xiang Zhou
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Frontiers in Neuroinformatics, 2019 Imaging genetic analyses use heritability calculations to measure the fraction of phenotypic variance attributable to additive genetic factors. We tested the agreement between heritability estimates provided by four methods that are used for heritability
Peter Kochunov +21 more
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Aquaculture Reports, 2021 The occurrence of inbreeding over generations cannot be avoided in breeding practice because of limited effective population sizes, and inbreeding is expected to decrease the heritability within populations.
Jiafeng Fang, Ziqiang Han, Qi Li
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