High heritability is compatible with the broad distribution of set point viral load in HIV carriers. [PDF]
PLoS Pathogens, 2015 Set point viral load in HIV patients ranges over several orders of magnitude and is a key determinant of disease progression in HIV. A number of recent studies have reported high heritability of set point viral load implying that viral genetic factors ...
Sebastian Bonhoeffer +2 more
doaj +5 more sources
Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review. [PDF]
PLoS GeneticsEstimating heritability has been fundamental in understanding the genetic contributions to complex disorders like late-onset Alzheimer's disease (LOAD) and provides a rationale for identifying genetic factors associated with disease susceptibility. While
Shiying Liu +13 more
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What does heritability of Alzheimer's disease represent?
PLoS ONE, 2023 IntroductionBoth late-onset Alzheimer's disease (AD) and ageing have a strong genetic component. In each case, many associated variants have been discovered, but how much missing heritability remains to be discovered is debated.
Emily Baker +14 more
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Optimal population size to detect quantitative trait loci in Korean native chicken: a simulation study [PDF]
Animal Bioscience, 2022 Objective A genomic region associated with a particular phenotype is called quantitative trait loci (QTL). To detect the optimal F2 population size associated with QTLs in native chicken, we performed a simulation study on F2 population derived from ...
Chiemela Peter Nwogwugwu +6 more
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Heritability estimation of osteoarthritis in the pig-tailed macaque (Macaca nemestrina) with a look toward future data collection [PDF]
PeerJ, 2014 We examine heritability estimation of an ordinal trait for osteoarthritis, using a population of pig-tailed macaques from the Washington National Primate Research Center (WaNPRC).
Peter B. Chi +3 more
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BMC Bioinformatics, 2021 Background Heritability is a central measure in genetics quantifying how much of the variability observed in a trait is attributable to genetic differences.
The Tien Mai +2 more
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BMI heritability and its relationship with puberty in 6 – 18-year-old twins
Zhongguo gonggong weisheng, 2023 ObjectiveTo analyze the heritability of body mass index (BMI) and the impact of puberty on the heritability among twins aged 6 – 18 years in Shandong province.
Tingting GUO, Yunjie BAI, Aiping FAN
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On Negative Heritability and Negative Estimates of Heritability [PDF]
Genetics, 2017 Abstract We consider the problem of interpreting negative maximum likelihood estimates of heritability that sometimes arise from popular statistical models of additive genetic variation. These may result from random noise acting on estimates of genuinely positive heritability, but we argue that they may also arise from ...
Steinsaltz, David +2 more
openaire +5 more sources
Using extended genealogy to estimate components of heritability for 23 quantitative and dichotomous traits. [PDF]
PLoS Genetics, 2013 Important knowledge about the determinants of complex human phenotypes can be obtained from the estimation of heritability, the fraction of phenotypic variation in a population that is determined by genetic factors.
Noah Zaitlen +6 more
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Genomic prediction and quantitative trait locus discovery in a cassava training population constructed from multiple breeding stages [PDF]
, 2020 Open Access Article; Published online: 11 Dec 2019Assembly of a training population (TP) is an important component of effective genomic selection‐based breeding programs.
Egesi, C. +11 more
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