Results 141 to 150 of about 152,085 (301)

Establishment of Humanized EFNB2/B3 Murine Models for Investigating Nipah Virus Pathogenesis

Animal Research and One Health, EarlyView.
ABSTRACT Nipah virus (NiV) is a zoonotic paramyxovirus classified as a WHO priority pathogen, which causes severe respiratory disease and encephalitis in humans with high mortality. Currently, no licensed vaccines or specific antiviral therapies are available.
Wei Dong, Ning Liu, Weining Kong, Xiang Gao, Feifei Guan, Shan Gao, Yuanwu Ma   +6 more
wiley   +1 more source

The Generality of Personality Heritability

, 2010
The present research examined the relationship between heritability and response time for the Big Five personality facets in three samples of adults and adolescents.
Kimio Yoshimura, Yoshimura, Kimio, Ekehammar, Bo,, Ando, Juko,, Hedlund, Lars-Erik, Ando, Juko, Ono, Yutaka, Akrami, Nazar,, Ono, Yutaka,, Juko Ando, Shinji Yamagata, Yoshimura, Kimio,, Lars-Erik Hedlund, Hedlund, Lars-Erik,, Nazar Akrami, Yamagata, Shinji,, Akrami, Nazar, Yamagata, Shinji, Bo Ekehammar, Yutaka Ono   +19 more
core   +1 more source

Engineering Biology Beyond Single Genes: Advances and Challenges in Multiplex Genome Editing

Animal Research and One Health, EarlyView.
Multiplex genome editing is transforming genome engineering from single‐gene perturbation to network‐level control, yet its broader application remains limited by challenges in gRNA array engineering, delivery technologies, and safety management. Emerging AI‐driven approaches are accelerating guide RNA design and CRISPR effector optimization for ...
Linli Wang, Yongbin Liu, Hongbing Han
wiley   +1 more source

ANK1 and EPB41 Variants and The Risk of Glucocorticoid‐Induced Osteonecrosis

Arthritis &Rheumatology, EarlyView.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Estimation of Heritability in Myopic Twin Studies

, 2012
[[abstract]]Purpose: To examine the genetic and environmental factors for myopia at the family level, as well as risk factors such as ocular measurements and environmental covariates at the individual level, by analysis of myopic twin data.
Tsai, Miao-Yu; Lin, Luke L-K; Lee, Vicky; Chen, Chien-Jen; Shih, Yung-Feng
core  

Genetic and population analyses implicate thyroid‐related regulation of RNF144B in chondrocalcinosis

Arthritis &Rheumatology, Accepted Article.
Objectives Chondrocalcinosis, characterized by calcium crystal deposition within articular cartilage, affects 5–15% of the general population and has recently been identified as an osteoarthritis risk factor. However, Its biological pathways remain unclear.
Yahong Wu, Yanning Xu, Paul C. Okoro, Sirine Saafi, Jard de Vries, Xiaoyi Qi, Edwin H.G. Oei, Sita Bierma‐Zeinstra, Trudy Voortman, David Felson, Joyce BJ van Meurs, Layal Chaker, J. Mark Wilkinson, Michelle S. Yau, Jessica Bertrand, Cindy G. Boer   +15 more
wiley   +1 more source

Feed-forward neural networks for genomic selection: insights into varying levels of dominance heritability

BMC Genomics
Genomic selection enables the prediction of genetic and breeding values from high-dimensional marker data, improving selection efficiency in breeding programs.
Hamid Sahebalam, Mohsen Gholizadeh
doaj   +1 more source

Precision medicine in paediatrics: Progress and priorities

British Journal of Clinical Pharmacology, EarlyView.
Precision medicine is revolutionizing personalized healthcare, advancing both diagnostics and therapeutics at an unprecedented pace. Reviewing the paediatric applications of pharmacometrics, pharmacogenomics and advanced therapy medicinal products highlights not only the relevance of these exciting innovations to frontline care but also the significant
Nicola Husain, Claire Booth, Joseph F. Standing, Charlotte I. S. Barker   +3 more
wiley   +1 more source

How developmental stressors affect mitochondrial respiratory function: a systematic review and meta‐analysis

Biological Reviews, EarlyView.
ABSTRACT The environmental conditions organisms experience during early development can have powerful and sustained effects on morphology, physiology, behaviour, and performance. Such developmental effects can influence reproductive success, survival, and life‐history strategies and can be transmitted across generations (i.e.
Ondi L. Crino, Christopher R. Friesen, Geoffrey E. Hill, Dalton C. Leibold, Pablo Recio, Karine Salin, Kristoffer H. Wild, Daniel W.A. Noble   +7 more
wiley   +1 more source

The Association Between Parental Food Intake and Loss of Control Eating in Children: An Experimental Test Meal Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Loss of control (LOC) eating in children is prospectively associated with excessive weight gain and elevated psychopathology. Parental LOC eating and negative mood in children have been linked to child LOC eating; however, objective evidence on parent–child concordance in energy intake and sense of LOC over eating, particularly in ...
Sarah Maria Luise Thorwarth, Ricarda Schmidt, Anja Hilbert   +2 more
wiley   +1 more source