Results 161 to 170 of about 355,175 (361)

Navigating the Genetic Risk of Chemotherapy‐Induced Hearing Loss in the Stria Vascularis

Clinical Pharmacology &Therapeutics, EarlyView.
Cisplatin is a chemotherapy drug that causes permanent hearing loss by damaging a critical tissue lining the inner ear, called the stria vascularis (SV). Currently, the molecular mechanisms of SV damage are largely unknown and the incidence of ototoxicity in patients cannot be reliably predicted.
Tara Lazetic, Deanne Nixie R. Miao, Britt I. Drögemöller, Alain Dabdoub, Julia M. Abitbol   +4 more
wiley   +1 more source

The cortisol response to ACTH in pigs, heritability and influence of corticosteroid-binding globulin

, 2015
Catherine Larzul, Elena Terenina, Aline Foury, Yvon Billon, Isabelle Louveau, Élodie Merlot, Pierre Mormède   +6 more
openalex   +1 more source

Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology

Developmental Dynamics, EarlyView.
Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley   +1 more source

Genetic heritability and shared environmental factors among twin pairs with autism.

Archives of General Psychiatry, 2011
J. Hallmayer, Sue C. Cleveland, Andrea Torres, Jennifer M. Phillips, B. Cohen, Tiffany Torigoe, Janet Miller, A. Fedele, Jack Collins, K. Smith, L. Lotspeich, L. Croen, S. Ozonoff, C. Lajonchere, J. Grether, N. Risch   +15 more
semanticscholar   +1 more source

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Gene-environment interaction explains a part of missing heritability in human body mass index

, 2023
Hae‐Un Jung, Dong Jun Kim, Eun Ju Baek, Ju Yeon Chung, Tae Woong Ha, Han‐Kyul Kim, Ji‐One Kang, Ji Eun Lim, Bermseok Oh   +8 more
openalex   +2 more sources

The Heritability of Autism Spectrum Disorder

Journal of the American Medical Association (JAMA), 2017
S. Sandin, P. Lichtenstein, R. Kuja-Halkola, C. Hultman, H. Larsson, A. Reichenberg   +5 more
semanticscholar   +1 more source

Epigenotoxicity: Decoding the epigenetic imprints of genotoxic agents and their implications for regulatory genetic toxicology

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Regulatory genetic toxicology focuses on DNA damage and subsequent gene mutations. However, genotoxic agents can also affect epigenetic marks, and incorporation of epigenetic data into the regulatory framework may thus enhance the accuracy of risk assessment.
Roger Godschalk, Christopher Faulk, Jessica LaRocca, Jan van Benthem, Francesco Marchetti   +4 more
wiley   +1 more source

The Genetic Parameters for Average Daily Gain and Kleiber Ratio in Charolaise Breed

Scientific Papers Animal Science and Biotechnologies
The objective of this paper was to estimate the genetic parameters for average daily gain from 200 days to 365 days and Kleiber ratio in Charolaise breed with maternal animal model. The data were represented by 582 records of Charolaise cattle breed. The
Rodica Ștefania Pelmuș, Mircea Cătălin Rotar, Mihail Alexandru Gras, Cristina Van   +3 more
doaj  

Consensus findings of an International Workshops on Genotoxicity Testing workshop on using transcriptomic biomarkers to predict genotoxicity

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Gene expression biomarkers have the potential to identify genotoxic and non‐genotoxic carcinogens, providing opportunities for integrated testing and reducing animal use. In August 2022, an International Workshops on Genotoxicity Testing (IWGT) workshop was held to critically review current methods to identify genotoxicants using ...
Roland Froetschl, J. Christopher Corton, Henghong Li, Jiri Aubrecht, Scott S. Auerbach, Florian Caiment, Tatyana Y. Doktorova, Yurika Fujita, Danyel Jennen, Naoki Koyama, Matthew J. Meier, Roman Mezencev, Leslie Recio, Takayoshi Suzuki, Carole L. Yauk   +14 more
wiley   +1 more source