Results 21 to 30 of about 239,135 (326)

Phenome-wide heritability analysis of the UK Biobank.

PLoS Genetics, 2017
Heritability estimation provides important information about the relative contribution of genetic and environmental factors to phenotypic variation, and provides an upper bound for the utility of genetic risk prediction models.
Tian Ge, Chia-Yen Chen, Benjamin M Neale, Mert R Sabuncu, Jordan W Smoller   +4 more
doaj   +1 more source

Spatially Dense 3D Facial Heritability and Modules of Co-heritability in a Father-Offspring Design

Frontiers in Genetics, 2018
Introduction: The human face is a complex trait displaying a strong genetic component as illustrated by various studies on facial heritability. Most of these start from sparse descriptions of facial shape using a limited set of landmarks.
Hanne Hoskens, Hanne Hoskens, Jiarui Li, Jiarui Li, Karlijne Indencleef, Karlijne Indencleef, Dorothy Gors, Dorothy Gors, Maarten H. D. Larmuseau, Stephen Richmond, Alexei I. Zhurov, Greet Hens, Hilde Peeters, Peter Claes, Peter Claes, Peter Claes   +15 more
doaj   +1 more source

Heritable and non-heritable uncommon causes of stroke

Journal of Neurology, 2020
Despite intensive investigations, about 30% of stroke cases remains of undetermined origin. After exclusion of common causes of stroke, there is a number of rare heritable and non-heritable conditions, which often remain misdiagnosed, that should be additionally considered in the diagnosis of cryptogenic stroke.
Bersano, A., Kraemer, M., Burlina, A., Mancuso, M., Finsterer, J., Sacco, S., Salvarani, C., Caputi, L., Chabriat, H., Oberstein, S. Lesnik, Federico, A., Lasserve, E. Tournier, Hunt, D., Dichgans, M., Arnold, M., Debette, Stephanie, Markus, H. S.   +16 more
openaire   +5 more sources

Estimates of genetic parameters of distal limb fracture and superficial digital flexor tendon injury in UK Thoroughbred racehorses [PDF]

, 2014
A retrospective cohort study of distal limb fracture and superficial digital flexor tendon (SDFT) injury in Thoroughbred racehorses was conducted using health records generated by the British Horseracing Authority (BHA) between 2000 and 2010.
Blott, Sarah C., Lewis, Thomas W., Mellor, Dominic J., Parkin, Timothy D.H., Stirk, Anthony J., Welsh, Claire E.   +5 more
core   +1 more source

Estimating the heritability of psychological measures in the Human Connectome Project dataset.

PLoS ONE, 2020
The Human Connectome Project (HCP) is a large structural and functional MRI dataset with a rich array of behavioral and genotypic measures, as well as a biologically verified family structure. This makes it a valuable resource for investigating questions
Yanting Han, Ralph Adolphs
doaj   +1 more source

Effect of body composition methodology on heritability estimation of body fatness [PDF]

, 2012
Heritability estimates of human body fatness vary widely and the contribution of body composition methodology to this variability is unknown. The effect of body composition methodology on estimations of genetic and environmental contributions to body ...
Bouchard, Thomas J., Das, Sai Krupa, Dawson-Hughes, Bess, Elder, Sonya J., Fuss, Paul J., Greenberg, Andrew S., Heymsfield, Steven B., McCrory, Megan A., Neale, Michael C., Pittas, Anastassios G., Roberts, Susan B., Saltzman, Edward   +11 more
core   +1 more source

The Familial Clustering of Age at Menarche in Extended Twin Families [PDF]

, 2007
The timing of puberty is complex, possibly involving many genetic factors that may interact with environmental influences. Familial resemblance for age at menarche was studied in a sample of 4,995 female twins, 1,296 sisters, 2,946 mothers and 635 female
A Must, A Pickles, B Towne, CL Sisk, DB Pillemer, DI Boomsma, Dorret I. Boomsma, DS Falconer, DZ Loesch, EB Greif, FJP Ebling, FL Schmidt, G Willemsen, G Wyshak, J Kaprio, JH Stubbe, JL Jinks, JM Meyer, JM Vink, JR Koopmans, L Ibanez, L Zacharias, MR Palmert, SA Treloar, SM Berg van den, SR Ojeda, Stéphanie M. van den Berg   +26 more
core   +11 more sources

Accurate Genomic Prediction Of Human Height [PDF]

, 2017
We construct genomic predictors for heritable and extremely complex human quantitative traits (height, heel bone density, and educational attainment) using modern methods in high dimensional statistics (i.e., machine learning).
Avery, Steven G., Campos, Gustavo de los, Hsu, Stephen D. H., Lello, Louis, Tellier, Laurent, Vazquez, Ana   +5 more
core   +1 more source

Single nucleotide polymorphisms in the CDH18 gene affect growth traits in Hu sheep

Animal Research and One Health, EarlyView., 2023
Abstract Growth traits are critical economic traits in sheep. Genetic polymorphism has a great influence on the improvement of sheep traits. The aim of this study was to analyze the effect of cadherin 18 (CDH18) gene polymorphisms on growth traits in Hu sheep.
Tianyi Liu, Yazhen Bi, Jingjing Bao, Mingyu Shang, Wenping Hu, Li Zhang   +5 more
wiley   +1 more source

Controlling the Overfitting of Heritability in Genomic Selection through Cross Validation. [PDF]

, 2017
In genomic selection (GS), all the markers across the entire genome are used to conduct marker-assisted selection such that each quantitative trait locus of complex trait is in linkage disequilibrium with at least one marker.
Jia, Zhenyu
core   +2 more sources